Matches in SemOpenAlex for { <https://semopenalex.org/work/W2993584691> ?p ?o ?g. }
- W2993584691 abstract "Abstract 16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. We analyzed resting-state functional magnetic resonance imaging data from 101 CNV carriers, 755 individuals with idiopathic ASD, SZ, or ADHD and 1,072 controls. We used CNV FC-signatures to identify dimensions contributing to complex idiopathic conditions. CNVs had large mirror effects on FC at the global and regional level. Thalamus, somatomotor, and posterior insula regions played a critical role in dysconnectivity shared across deletions, duplications, idiopathic ASD, SZ but not ADHD. Individuals with higher similarity to deletion FC-signatures exhibited worse cognitive and behavioral symptoms. Deletion similarities identified at the connectivity level could be related to the redundant associations observed genome-wide between gene expression spatial patterns and FC-signatures. Results may explain why many CNVs affect a similar range of neuropsychiatric symptoms." @default.
- W2993584691 created "2019-12-13" @default.
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- W2993584691 date "2019-12-06" @default.
- W2993584691 modified "2023-10-18" @default.
- W2993584691 title "Neuropsychiatric mutations delineate functional brain connectivity dimensions contributing to autism and schizophrenia" @default.
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- W2993584691 doi "https://doi.org/10.1101/862615" @default.
- W2993584691 hasPublicationYear "2019" @default.