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- W2993600526 abstract "Postpartum depression (PPD) is a psychiatric disorder that defined as a subtype of major depressive disorder (MDD) which may result from reproductive hormone fluctuations subsequent to childbirth. Approximately 10-15% of women experience postpartum depression (PPD) after baby delivery. It is hypothesized that the depression symptoms may be attenuated with omega-3 fatty acids. In order to examine this hypothesis, ovariectomized female rats underwent hormone-simulated pregnancy (HSP) regimen and received progesterone and estradiol benzoate or vehicle for 23 days, mimicking the actual rat’s pregnancy. Forced feeding of menhaden fish oil (rich in omega-3) with three doses of 1, 3 and 9 g/kg/d, fluoxetine (an antidepressant drug) 15mg/kg/d and distilled water 2ml/d per rat started in six experimental groups on postpartum day 1 and continued for 15 consecutive days. On postpartum day 2, 8 and 15 all groups were tested in the forced swimming test (FST) and open field test (OFT). The seventh experimental group (normal control), which had not experienced neither ovariectomy nor injection, received only distilled water 2ml/d through oral gavage for 15 consecutive days and underwent the same behavioral tests as well. Animals were sacrificed by decapitation on postpartum day 15 following exposure to behavioral tests and blood and brain samples were collected. Plasma samples were utilized to assay levels of corticosterone and pro-inflammatory cytokines using ELISA and Procarta immunossay technique respectively. The corticosterone levels of hippocampus were measured by ELISA as well. Significant differences between groups were evaluated using one-way analysis of variance (ANOVA), followed by the post hoc Tukey’s multiple comparison test when appropriate P 0.05) in immobility time in FST and in the levels of corticosterone and pro-inflammatory cytokines. Taken together, these results suggest that menhaden fish oil, rich in omega-3, exerts beneficial effect on postpartum depression and decreases the biomarkers related to depression." @default.
- W2993600526 created "2019-12-13" @default.
- W2993600526 creator A5067068467 @default.
- W2993600526 date "2014-03-01" @default.
- W2993600526 modified "2023-09-27" @default.
- W2993600526 title "Antidepressant-like effects of menhaden fish oil in postpartum-induced model of depression in rats" @default.
- W2993600526 hasPublicationYear "2014" @default.
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