FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2993607869> ?p ?o ?g. }

• W2993607869 abstract "Abstract Atherosclerosis is the major cause of ischemic coronary heart diseases and characterized by the infiltration of cholesterol-accumulating macrophages in the vascular wall. Although sphingolipids are implicated in atherosclerosis as both membrane components and lipid mediators, the precise role of sphingolipids in atherosclerosis remains elusive. Here, we found that genetic deficiency of sphingosine kinase-2 (SphK2) but not SphK1 aggravates the formation of atherosclerotic lesions in mice with ApoE deficiency. Bone marrow chimaera experiments show the involvement of SphK2 expressed in bone marrow-derived cells. In macrophages, deficiency of SphK2, a major SphK isoform in this cell type, results in increases in cellular sphingosine and ceramides. SphK2-deficient macrophages have increases in lipid droplet-containing autophagosomes and autolysosomes and defective lysosomal degradation of lipid droplets via autophagy with an impaired luminal acidic environment and proteolytic activity in the lysosomes. Transgenic overexpression of SphK1 in SphK2-deficient mice rescued aggravation of atherosclerosis and abnormalities of autophagosomes and lysosomes in macrophages with reductions of sphingosine, suggesting at least partial overlapping actions of two SphKs. Taken together, these results indicate that SphK2 is required for autophagosome- and lysosome-mediated catabolism of intracellular lipid droplets to impede the development of atherosclerosis; therefore, SphK2 may be a novel target for treating atherosclerosis." @default.
• W2993607869 created "2019-12-13" @default.
• W2993607869 creator A5016838749 @default.
• W2993607869 creator A5025255590 @default.
• W2993607869 creator A5026162371 @default.
• W2993607869 creator A5029321254 @default.
• W2993607869 creator A5037810291 @default.
• W2993607869 creator A5048492327 @default.
• W2993607869 creator A5054725382 @default.
• W2993607869 creator A5058121331 @default.
• W2993607869 creator A5060462446 @default.
• W2993607869 creator A5074222420 @default.
• W2993607869 creator A5077332068 @default.
• W2993607869 date "2019-12-04" @default.
• W2993607869 modified "2023-10-15" @default.
• W2993607869 title "Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation" @default.
• W2993607869 cites W1814876547 @default.
• W2993607869 cites W1895032340 @default.
• W2993607869 cites W1967966438 @default.
• W2993607869 cites W1972483153 @default.
• W2993607869 cites W1977499678 @default.
• W2993607869 cites W1978707192 @default.
• W2993607869 cites W1983619827 @default.
• W2993607869 cites W1989605865 @default.
• W2993607869 cites W1991115604 @default.
• W2993607869 cites W1993489023 @default.
• W2993607869 cites W1993918137 @default.
• W2993607869 cites W1997567789 @default.
• W2993607869 cites W2001026082 @default.
• W2993607869 cites W2007505836 @default.
• W2993607869 cites W2011345944 @default.
• W2993607869 cites W2014959138 @default.
• W2993607869 cites W2015805615 @default.
• W2993607869 cites W2021609230 @default.
• W2993607869 cites W2027183994 @default.
• W2993607869 cites W2027540537 @default.
• W2993607869 cites W2031562279 @default.
• W2993607869 cites W2033179866 @default.
• W2993607869 cites W2033691850 @default.
• W2993607869 cites W2035520825 @default.
• W2993607869 cites W2050001477 @default.
• W2993607869 cites W2051481532 @default.
• W2993607869 cites W2058006650 @default.
• W2993607869 cites W2061265251 @default.
• W2993607869 cites W2063920469 @default.
• W2993607869 cites W2071465358 @default.
• W2993607869 cites W2080878773 @default.
• W2993607869 cites W2093317801 @default.
• W2993607869 cites W2096490923 @default.
• W2993607869 cites W2097359245 @default.
• W2993607869 cites W2098548295 @default.
• W2993607869 cites W2099057738 @default.
• W2993607869 cites W2107134200 @default.
• W2993607869 cites W2112034357 @default.
• W2993607869 cites W2113934014 @default.
• W2993607869 cites W2138786573 @default.
• W2993607869 cites W2143068056 @default.
• W2993607869 cites W2147118641 @default.
• W2993607869 cites W2158353135 @default.
• W2993607869 cites W2159801302 @default.
• W2993607869 cites W2181260782 @default.
• W2993607869 cites W2263111897 @default.
• W2993607869 cites W2419601133 @default.
• W2993607869 cites W2461199031 @default.
• W2993607869 cites W2547808854 @default.
• W2993607869 cites W2566359356 @default.
• W2993607869 cites W2580782968 @default.
• W2993607869 cites W2596802012 @default.
• W2993607869 cites W2605924378 @default.
• W2993607869 cites W2743877546 @default.
• W2993607869 cites W2765749162 @default.
• W2993607869 cites W2804267567 @default.
• W2993607869 cites W2886254151 @default.
• W2993607869 cites W2909806584 @default.
• W2993607869 doi "https://doi.org/10.1038/s41598-019-54877-6" @default.
• W2993607869 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6892873" @default.
• W2993607869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31797978" @default.
• W2993607869 hasPublicationYear "2019" @default.
• W2993607869 type Work @default.
• W2993607869 sameAs 2993607869 @default.
• W2993607869 citedByCount "21" @default.
• W2993607869 countsByYear W29936078692020 @default.
• W2993607869 countsByYear W29936078692021 @default.
• W2993607869 countsByYear W29936078692022 @default.
• W2993607869 countsByYear W29936078692023 @default.
• W2993607869 crossrefType "journal-article" @default.
• W2993607869 hasAuthorship W2993607869A5016838749 @default.
• W2993607869 hasAuthorship W2993607869A5025255590 @default.
• W2993607869 hasAuthorship W2993607869A5026162371 @default.
• W2993607869 hasAuthorship W2993607869A5029321254 @default.
• W2993607869 hasAuthorship W2993607869A5037810291 @default.
• W2993607869 hasAuthorship W2993607869A5048492327 @default.
• W2993607869 hasAuthorship W2993607869A5054725382 @default.
• W2993607869 hasAuthorship W2993607869A5058121331 @default.
• W2993607869 hasAuthorship W2993607869A5060462446 @default.
• W2993607869 hasAuthorship W2993607869A5074222420 @default.
• W2993607869 hasAuthorship W2993607869A5077332068 @default.
• W2993607869 hasBestOaLocation W29936078691 @default.
• W2993607869 hasConcept C134018914 @default.
• W2993607869 hasConcept C170493617 @default.

• next