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- W2993619954 abstract "The long-term programming effects of neonatal hypermelatonemia on adult ovarian weight andfunctions and serum hormone profiles have been studies in the Charles Foster strain of rats. Theneonates were administered melatonin (MT) i.p. (40 μg/animal/day) in the evening from day 0 today 21 post partum. The serum titres of T3, T4, estradiol and progesterone and, ovarian weightand histoarchitecture were assessed on post partum days 22, 45 and 90. Though there was nodifference in adult ovary weight between control and MT programmed rats, there was increaseddensity of follicles with significantly higher number of antral follicles and corpora lutea in MTrats. The number of atretic follicles showed a significant decrement. In conclusion, the presentobservations reveal increased progesterone but decreased estrogen level and increasedprotection against follicular apoptosis in the adult due to neonatal melatonin programmingthereby increasing follicular number and corpora lutea." @default.
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- W2993619954 date "2011-01-01" @default.
- W2993619954 modified "2023-09-23" @default.
- W2993619954 title "Neonatal melatonin treatment has favorable quantitative and qualitative influence on adult ovarian functions in rat" @default.
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