FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2993668110> ?p ?o ?g. }

• W2993668110 endingPage "592" @default.
• W2993668110 startingPage "585" @default.
• W2993668110 abstract "Continuous digital hypothermia (CDH) prevents lamellar failure in the euglycaemic hyperinsulinaemic clamp (EHC) and oligofructose (OF) laminitis models, but the mechanisms remain unclear.To evaluate the effects of CDH on lamellar energy metabolism and perfusion in healthy horses and during EHC and OF laminitis models.In vivo experiment.Archived samples were used from Standardbred geldings that received no treatment (CON) (n = 8) or underwent EHC (n = 8) or OF (n = 6) laminitis models. Both forelimbs were instrumented with a lamellar microdialysis system, and one forelimb was cooled (CDH) with the other maintained at ambient temperature (AMB). Microdialysate was collected every 6 hours and analysed for glucose, lactate and pyruvate concentrations and lactate to pyruvate ratio (L:P). Microdialysis urea clearance was used to estimate lamellar tissue perfusion. Data were analysed using a mixed-effects linear regression model.Glucose did not change in CDH limbs relative to AMB in CON (P = .3), EHC (P = .3) or OF (P = .6) groups. There was a decrease in lactate (P < .001) and pyruvate (P < .01) in CDH limbs relative to AMB in all groups. L:P decreased in CON CDH relative to CON AMB (P < .001) but was not different in EHC (P = .6) and OF (P = .07) groups. Urea clearance decreased in CDH limbs relative to AMB in CON (P = .002) and EHC (P < .001), but not in OF (P = .4).The EHC model may not mimic natural endocrinopathic laminitis.CDH caused a marked decrease in lamellar glucose metabolism (CON, EHC and OF) and perfusion (CON and EHC) without affecting lamellar glucose concentration. Although cellular energy failure is not a primary pathophysiological event in EHC and OF laminitis models, CDH may act by limiting energy supply to pathologic cellular processes whilst preserving those critical to lamellar homoeostasis." @default.
• W2993668110 created "2019-12-13" @default.
• W2993668110 creator A5015867908 @default.
• W2993668110 creator A5027309562 @default.
• W2993668110 creator A5036971008 @default.
• W2993668110 creator A5053049581 @default.
• W2993668110 creator A5068997384 @default.
• W2993668110 creator A5078017258 @default.
• W2993668110 creator A5090857167 @default.
• W2993668110 creator A5040999855 @default.
• W2993668110 date "2020-02-12" @default.
• W2993668110 modified "2023-10-10" @default.
• W2993668110 title "The effect of continuous digital hypothermia on lamellar energy metabolism and perfusion during laminitis development in two experimental models" @default.
• W2993668110 cites W136899898 @default.
• W2993668110 cites W1537963327 @default.
• W2993668110 cites W1573796272 @default.
• W2993668110 cites W1588783749 @default.
• W2993668110 cites W1811048529 @default.
• W2993668110 cites W1919965361 @default.
• W2993668110 cites W1941795588 @default.
• W2993668110 cites W1958539631 @default.
• W2993668110 cites W1975266801 @default.
• W2993668110 cites W1975625393 @default.
• W2993668110 cites W1978293423 @default.
• W2993668110 cites W1978787887 @default.
• W2993668110 cites W1979177508 @default.
• W2993668110 cites W1979720992 @default.
• W2993668110 cites W1984153512 @default.
• W2993668110 cites W1987484538 @default.
• W2993668110 cites W1992162199 @default.
• W2993668110 cites W1996693828 @default.
• W2993668110 cites W2014298330 @default.
• W2993668110 cites W2015845137 @default.
• W2993668110 cites W2043087045 @default.
• W2993668110 cites W2070262847 @default.
• W2993668110 cites W2074946210 @default.
• W2993668110 cites W2076639254 @default.
• W2993668110 cites W2077853875 @default.
• W2993668110 cites W2084574885 @default.
• W2993668110 cites W2090232636 @default.
• W2993668110 cites W2096523744 @default.
• W2993668110 cites W2108524241 @default.
• W2993668110 cites W2110154943 @default.
• W2993668110 cites W2124290573 @default.
• W2993668110 cites W2139330583 @default.
• W2993668110 cites W2142294955 @default.
• W2993668110 cites W2143521538 @default.
• W2993668110 cites W2145647659 @default.
• W2993668110 cites W2160310432 @default.
• W2993668110 cites W2170046496 @default.
• W2993668110 cites W2200712909 @default.
• W2993668110 cites W2319718984 @default.
• W2993668110 cites W2338160181 @default.
• W2993668110 cites W2468417782 @default.
• W2993668110 cites W2618410483 @default.
• W2993668110 cites W2779145841 @default.
• W2993668110 cites W2790030923 @default.
• W2993668110 cites W2910373651 @default.
• W2993668110 cites W2911265402 @default.
• W2993668110 cites W2913157424 @default.
• W2993668110 cites W2972934631 @default.
• W2993668110 doi "https://doi.org/10.1111/evj.13215" @default.
• W2993668110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31793047" @default.
• W2993668110 hasPublicationYear "2020" @default.
• W2993668110 type Work @default.
• W2993668110 sameAs 2993668110 @default.
• W2993668110 citedByCount "5" @default.
• W2993668110 countsByYear W29936681102020 @default.
• W2993668110 countsByYear W29936681102021 @default.
• W2993668110 countsByYear W29936681102023 @default.
• W2993668110 crossrefType "journal-article" @default.
• W2993668110 hasAuthorship W2993668110A5015867908 @default.
• W2993668110 hasAuthorship W2993668110A5027309562 @default.
• W2993668110 hasAuthorship W2993668110A5036971008 @default.
• W2993668110 hasAuthorship W2993668110A5040999855 @default.
• W2993668110 hasAuthorship W2993668110A5053049581 @default.
• W2993668110 hasAuthorship W2993668110A5068997384 @default.
• W2993668110 hasAuthorship W2993668110A5078017258 @default.
• W2993668110 hasAuthorship W2993668110A5090857167 @default.
• W2993668110 hasConcept C126322002 @default.
• W2993668110 hasConcept C134018914 @default.
• W2993668110 hasConcept C146957229 @default.
• W2993668110 hasConcept C151730666 @default.
• W2993668110 hasConcept C2777390192 @default.
• W2993668110 hasConcept C2778081065 @default.
• W2993668110 hasConcept C2780365088 @default.
• W2993668110 hasConcept C2780762169 @default.
• W2993668110 hasConcept C50156730 @default.
• W2993668110 hasConcept C529278444 @default.
• W2993668110 hasConcept C55493867 @default.
• W2993668110 hasConcept C71924100 @default.
• W2993668110 hasConcept C86803240 @default.
• W2993668110 hasConceptScore W2993668110C126322002 @default.
• W2993668110 hasConceptScore W2993668110C134018914 @default.
• W2993668110 hasConceptScore W2993668110C146957229 @default.
• W2993668110 hasConceptScore W2993668110C151730666 @default.
• W2993668110 hasConceptScore W2993668110C2777390192 @default.
• W2993668110 hasConceptScore W2993668110C2778081065 @default.

• next