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• W2993742015 abstract "• Polysaccharide- and Cinchona alkaloid-based chiral stationary phases are studied. • ß -carboline, tetrahydroisoquinoline, and benzazepine analogues were enantioseparated. • Stereoselective retention and separation characteristics in HPLC and SFC are discussed. • Effects of structural peculiarities of the studied analytes are revealed. High-performance liquid chromatographic (HPLC) and subcritical fluid chromatographic (SFC) separations of the enantiomers of structurally diverse, basic ß -carboline, tetrahydroisoquinoline and benzazepine analogues of pharmacological interest were performed applying chiral stationary phases (CSPs) based on (i) neutral polysaccharides- and (ii) zwitterionic sulfonic acid derivatives of Cinchona alkaloids. The aim of this work was to reveal the influence of structural peculiarities on the enantiorecognition on both types of CSP through the investigation of the effects of the composition of the bulk solvent, the structures of the chiral analytes (SAs) and chiral selectors (SOs) on retention and stereoselectivity. As a general tendency, valid for all polysaccharide SOs studied, the increase of the concentration of the apolar component in the mobile phase ( n -hexane for LC or liquid CO 2 for SFC) was found to significantly increase retention, which in most cases, was accompanied with increased selectivity and resolution. In a way, similar behaviour was registered for the zwitterionic SOs. In polar ionic mode employing eluent systems composed of methanol and acetonitrile with organic acid and base additives, moderate increases in retention factor, selectivity and resolution were observed with increasing acetonitrile content. However, under SFC conditions, an extremely high increase in retention was observed with increased CO 2 content, while selectivity and resolution changed only slightly. Thermodynamic parameters derived from temperature dependence studies revealed that separations are controlled by enthalpy." @default.
• W2993742015 created "2019-12-13" @default.
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• W2993742015 date "2020-03-01" @default.
• W2993742015 modified "2023-10-16" @default.
• W2993742015 title "Enantioseparation of ß-carboline, tetrahydroisoquinoline and benzazepine analogues of pharmaceutical importance: Utilization of chiral stationary phases based on polysaccharides and sulfonic acid modified Cinchonaalkaloids in high-performance liquid and subcritical fluid chromatography" @default.
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• W2993742015 doi "https://doi.org/10.1016/j.chroma.2019.460771" @default.
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