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- W2993744169 abstract "Abstract Substania nigra (SNc) dopaminergic neurons show a pause-rebound firing pattern in response to aversive events. Because these neurons integrate information from predominately inhibitory brain areas, it is important to determine which inputs functionally inhibit the dopamine neurons and whether this pause-rebound firing pattern can be produced by a solely inhibitory input. Here, we functionally map genetically-defined inhibitory projections from the dorsal striatum (striosome and matrix) and globus pallidus (GPe; parvalbumin and Lhx6) onto SNc neurons. We find that GPe and striosomal inputs both pause firing in SNc neurons, but rebound firing only occurs after inhibition from striosomes. Indeed, we find that striosomes are synaptically optimized to produce rebound and preferentially inhibit a subpopulation of ventral, intrinsically rebound-ready SNc dopaminergic neurons on their reticulata dendrites. Therefore, we describe a self-contained dendrite-specific striatonigral circuit that can produce pause-rebound firing in the absence of excitatory input." @default.
- W2993744169 created "2019-12-13" @default.
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- W2993744169 date "2019-12-03" @default.
- W2993744169 modified "2023-09-25" @default.
- W2993744169 title "Functional dissection of basal ganglia inhibitory input onto SNc dopaminergic neurons" @default.
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- W2993744169 doi "https://doi.org/10.1101/856617" @default.
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