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- W2993776679 abstract "During early embryogenesis, the ectoderm is rapidly subdivided into neural, neural crest and sensory progenitors. How the onset of lineage determinants and the loss of pluripotency markers are temporally and spatially coordinated in vivo is still debated. Here we identify a critical role for the transcription factor PRDM1 in the orderly transition from epiblast to defined neural lineages in chick. PRDM1 is initially expressed broadly in the entire epiblast, but becomes gradually restricted as cell fates are specified. We find that PRDM1 is required for the loss of some pluripotency markers and the onset of neural, neural crest and sensory progenitor specifier genes. PRDM1 directly activates their expression by binding to their promoter regions and recruiting the histone demethylase Kdm4a to remove repressive histone marks. However, once neural lineage determinants become expressed, they in turn repress PRDM1, while prolonged PRDM1 expression now inhibits neural, neural crest and sensory progenitor genes suggesting that its downregulation is necessary for cells to maintain their identity. Therefore, PRDM1 plays multiple roles during ectodermal cell fate allocation." @default.
- W2993776679 created "2019-12-13" @default.
- W2993776679 creator A5073492144 @default.
- W2993776679 creator A5074131609 @default.
- W2993776679 creator A5090994794 @default.
- W2993776679 date "2019-01-01" @default.
- W2993776679 modified "2023-10-01" @default.
- W2993776679 title "PRDM1 controls the sequential activation of neural, neural crest and sensory progenitor determinants" @default.
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- W2993776679 doi "https://doi.org/10.1242/dev.181107" @default.
- W2993776679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6955226" @default.
- W2993776679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31806661" @default.
- W2993776679 hasPublicationYear "2019" @default.
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