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• W2993802912 abstract "Abstract NaCT is a Na + -coupled transporter for citrate expressed in hepatocytes and neurons. It is the mammalian ortholog of INDY (I’m Not Dead Yet), a transporter which modifies lifespan in Drosophila . Here we describe a hitherto unknown transport system for citrate in mammalian cells. When liver and mammary epithelial cells were pretreated with the iron supplement ferric ammonium citrate (FAC), uptake of citrate increased >10-fold. Iron chelators abrogated the stimulation of citrate uptake in FAC-treated cells. The iron exporter ferroportin had no role in this process. The stimulation of citrate uptake also occurred when Fe 3+ was added during uptake without pretreatment. Similarly, uptake of Fe 3+ was enhanced by citrate. The Fe 3+ -citrate uptake was coupled to Na + . This transport system was detectable in primary hepatocytes and neuronal cell lines. The functional features of this citrate transport system distinguish it from NaCT. Loss-of-function mutations in NaCT cause early-onset epilepsy and encephalopathy; the newly discovered Na + -coupled Fe 3+ -citrate transport system might offer a novel treatment strategy for these patients to deliver citrate into affected neurons independent of NaCT. It also has implications to iron-overload conditions where circulating free iron increases, which would stimulate cellular uptake of citrate and consequently affect multiple metabolic pathways." @default.
• W2993802912 created "2019-12-13" @default.
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• W2993802912 date "2018-02-06" @default.
• W2993802912 modified "2023-10-14" @default.
• W2993802912 title "RETRACTED ARTICLE: Identification of a novel Na+-coupled Fe3+-citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells" @default.
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• W2993802912 doi "https://doi.org/10.1038/s41598-018-20620-w" @default.
• W2993802912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5802838" @default.
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