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- W2993856871 abstract "A protein with anticoagulant and phospholipase Aa activities was isolated by chromatography, from Vipera berus venom. The phospholipase activity was demonstrated on isolated platelet phospholipids and derivatives were analysed on thin layer chromatography. The strong anticoagulant activity on recalcified platelet poor plasma, is not dependent upon any proteolytic effect. It is due to a competitive inhibition of the phospholipid procoagulant activity. The inhibition constant has been determined. The same molecule appeared to be responsible for both activities as demonstrated by continuous gradient chromatography, polyacrylamide gel electrophoresis and electro-focusing. Inactivation studies permitted to consider that each of both activities was related to a different site on the same molecule." @default.
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- W2993856871 date "1975-01-01" @default.
- W2993856871 modified "2023-09-23" @default.
- W2993856871 title "Phospholipase A2 and Competitive Inhibition of Procoagulant Phospholipids" @default.
- W2993856871 doi "https://doi.org/10.1055/s-0039-1689527" @default.
- W2993856871 hasPublicationYear "1975" @default.
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