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- W2993866869 endingPage "55" @default.
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- W2993866869 abstract "Antibodies and antibody-derived macromolecules have established themselves as the mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure–function relationships of antibodies provides a platform for protein engineering that has been exploited to generate a wide range of biologics for a host of therapeutic indications. In this review, our basic understanding of the antibody structure is described along with how that knowledge has leveraged the engineering of antibody and antibody-related therapeutics having the appropriate antigen affinity, effector function, and biophysical properties. The platforms examined include the development of antibodies, antibody fragments, bispecific antibody, and antibody fusion products, whose efficacy and manufacturability can be improved via humanization, affinity modulation, and stability enhancement. We also review the design and selection of binding arms, and avidity modulation. Different strategies of preparing bispecific and multispecific molecules for an array of therapeutic applications are included." @default.
- W2993866869 created "2019-12-13" @default.
- W2993866869 creator A5018279218 @default.
- W2993866869 creator A5047602731 @default.
- W2993866869 creator A5066462558 @default.
- W2993866869 creator A5080595084 @default.
- W2993866869 date "2019-12-03" @default.
- W2993866869 modified "2023-10-16" @default.
- W2993866869 title "Antibody Structure and Function: The Basis for Engineering Therapeutics" @default.
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