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• W2993993896 abstract "Following an acute ischemia/reperfusion of the rat retina, the activation of cytotoxic proteases, including calpain, results in necrosis and apoptosis of retinal ganglion cells resulting in their degeneration. Using a systemically administered calpain inhibitor that crosses the Blood-RetinalBarrier would provide for novel systemic intervention that protects the retina from acute injury and lost function. Here we study a novel calpain peptide inhibitor, cysteic–leucyl–argininal (CYLA), in an in vivo rat model of retinal ischemia to determine functional protection using electroretinography. The CYLA-prodrug was administered intraperitoneally before and/or after ischemia-reperfusion at concentrations of 20-40 mg/kg. We found that administering 20 mg/kg CYLA even only after ischemia provides significant preservation of retinal function." @default.
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• W2993993896 date "2009-04-28" @default.
• W2993993896 modified "2023-09-24" @default.
• W2993993896 title "A Novel Calpain Inhibitor for the Treatment of Transient Retinal Ischemia in the Rat" @default.
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