Matches in SemOpenAlex for { <https://semopenalex.org/work/W2993999015> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2993999015 abstract "Abstract Multiple myeloma (MM) is characterized by a profound genomic instability and a highly variable clinical course. To comprehensively analyze the effects of copy number alterations on gene activity and prognosis, we applied novel bioinformatics and computational approaches to integrate high-resolution aCGH data (Agilent 244K array) and gene expression profiling data (Affymetrix U133Plus2.0 array) from CD138-selected plasma cells from 92 newly diagnosed MM treated with high-dose therapy and stem cell transplantation. We identified what we have termed the “atom region” (AR). ARs are found throughout the genome and define recurrent breakpoint boundaries of sub-chromosomal loss or gain. Genes coding for miRNAs were significantly enriched in regions of the genome defined by ARs. Although many AR-related breakpoints lie in intergenic regions, and thus capture whole genes, a substantial number were identified within genes, making these genes strong candidate disease genes. We found that gain of 1q and loss of 1p represent the most significant copy number alterations linked to early disease-related death. Importantly, 1q gains and 1p loss were significantly linked to a recently described 70-gene expression model of high-risk disease predominated by increased expression of genes mapping to 1q and reduced expression of genes mapping to 1p (1). Gain of 1q and loss of 1p were also highly correlated with a gene-expression-based proliferation index widely used across many tumor types. We provide evidence that gain of 8q24 was also highly correlated with the 70-gene high-risk score, but not the proliferation index. 8q24 gains and survival were linked to elevated expression of EIF2C2/AGO2, a master regulator of microRNA expression and maturation and an overexpressed gene previously identified in our 70-gene high-risk model (1). Interestingly, although the expression of MYC, which also maps to 8q24, was related to copy number changes, its expression was not related to survival. Given the importance of AGO2 in B-cell development (2), and miRNAs in cancer, detailed functional studies of the potential role of AGO2 in MM are underway." @default.
- W2993999015 created "2019-12-13" @default.
- W2993999015 creator A5000879635 @default.
- W2993999015 creator A5001958312 @default.
- W2993999015 creator A5007143665 @default.
- W2993999015 creator A5007152490 @default.
- W2993999015 creator A5012932489 @default.
- W2993999015 creator A5021427793 @default.
- W2993999015 creator A5027806317 @default.
- W2993999015 creator A5041814944 @default.
- W2993999015 creator A5063151492 @default.
- W2993999015 creator A5073180479 @default.
- W2993999015 creator A5075794110 @default.
- W2993999015 creator A5078509967 @default.
- W2993999015 creator A5090044223 @default.
- W2993999015 date "2008-11-16" @default.
- W2993999015 modified "2023-09-27" @default.
- W2993999015 title "Integration of DNA Copy Number and Gene Expression Alterations Reveal Novel Insights into the Molecular Pathogenesis and Prognosis of Multiple Myeloma" @default.
- W2993999015 cites W2119962312 @default.
- W2993999015 cites W2150997370 @default.
- W2993999015 doi "https://doi.org/10.1182/blood.v112.11.250.250" @default.
- W2993999015 hasPublicationYear "2008" @default.
- W2993999015 type Work @default.
- W2993999015 sameAs 2993999015 @default.
- W2993999015 citedByCount "1" @default.
- W2993999015 crossrefType "journal-article" @default.
- W2993999015 hasAuthorship W2993999015A5000879635 @default.
- W2993999015 hasAuthorship W2993999015A5001958312 @default.
- W2993999015 hasAuthorship W2993999015A5007143665 @default.
- W2993999015 hasAuthorship W2993999015A5007152490 @default.
- W2993999015 hasAuthorship W2993999015A5012932489 @default.
- W2993999015 hasAuthorship W2993999015A5021427793 @default.
- W2993999015 hasAuthorship W2993999015A5027806317 @default.
- W2993999015 hasAuthorship W2993999015A5041814944 @default.
- W2993999015 hasAuthorship W2993999015A5063151492 @default.
- W2993999015 hasAuthorship W2993999015A5073180479 @default.
- W2993999015 hasAuthorship W2993999015A5075794110 @default.
- W2993999015 hasAuthorship W2993999015A5078509967 @default.
- W2993999015 hasAuthorship W2993999015A5090044223 @default.
- W2993999015 hasConcept C104317684 @default.
- W2993999015 hasConcept C120821319 @default.
- W2993999015 hasConcept C124942203 @default.
- W2993999015 hasConcept C141231307 @default.
- W2993999015 hasConcept C150194340 @default.
- W2993999015 hasConcept C166608930 @default.
- W2993999015 hasConcept C18431079 @default.
- W2993999015 hasConcept C206936463 @default.
- W2993999015 hasConcept C30481170 @default.
- W2993999015 hasConcept C54355233 @default.
- W2993999015 hasConcept C55548728 @default.
- W2993999015 hasConcept C69991583 @default.
- W2993999015 hasConcept C70721500 @default.
- W2993999015 hasConcept C7602840 @default.
- W2993999015 hasConcept C86803240 @default.
- W2993999015 hasConceptScore W2993999015C104317684 @default.
- W2993999015 hasConceptScore W2993999015C120821319 @default.
- W2993999015 hasConceptScore W2993999015C124942203 @default.
- W2993999015 hasConceptScore W2993999015C141231307 @default.
- W2993999015 hasConceptScore W2993999015C150194340 @default.
- W2993999015 hasConceptScore W2993999015C166608930 @default.
- W2993999015 hasConceptScore W2993999015C18431079 @default.
- W2993999015 hasConceptScore W2993999015C206936463 @default.
- W2993999015 hasConceptScore W2993999015C30481170 @default.
- W2993999015 hasConceptScore W2993999015C54355233 @default.
- W2993999015 hasConceptScore W2993999015C55548728 @default.
- W2993999015 hasConceptScore W2993999015C69991583 @default.
- W2993999015 hasConceptScore W2993999015C70721500 @default.
- W2993999015 hasConceptScore W2993999015C7602840 @default.
- W2993999015 hasConceptScore W2993999015C86803240 @default.
- W2993999015 hasLocation W29939990151 @default.
- W2993999015 hasOpenAccess W2993999015 @default.
- W2993999015 hasPrimaryLocation W29939990151 @default.
- W2993999015 hasRelatedWork W1027433819 @default.
- W2993999015 hasRelatedWork W1409057506 @default.
- W2993999015 hasRelatedWork W1992693736 @default.
- W2993999015 hasRelatedWork W1997695524 @default.
- W2993999015 hasRelatedWork W2010369997 @default.
- W2993999015 hasRelatedWork W2014385093 @default.
- W2993999015 hasRelatedWork W2050383354 @default.
- W2993999015 hasRelatedWork W2071271062 @default.
- W2993999015 hasRelatedWork W2128188406 @default.
- W2993999015 hasRelatedWork W2143498954 @default.
- W2993999015 hasRelatedWork W2313776939 @default.
- W2993999015 hasRelatedWork W2319010905 @default.
- W2993999015 hasRelatedWork W2336868094 @default.
- W2993999015 hasRelatedWork W2507663743 @default.
- W2993999015 hasRelatedWork W2624653528 @default.
- W2993999015 hasRelatedWork W2943182067 @default.
- W2993999015 hasRelatedWork W2960393442 @default.
- W2993999015 hasRelatedWork W2968349165 @default.
- W2993999015 hasRelatedWork W2991940988 @default.
- W2993999015 hasRelatedWork W3140181288 @default.
- W2993999015 isParatext "false" @default.
- W2993999015 isRetracted "false" @default.
- W2993999015 magId "2993999015" @default.
- W2993999015 workType "article" @default.