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• W2994044994 startingPage "144225" @default.
• W2994044994 abstract "Recently, extensive researches have explored the potential biomarker roles of microRNA-210 (miR-210) in non-small cell lung cancer (NSCLC). Inconsistent results, however, have prevented its widespread use in diagnosis. In the present study, we aimed to clarify the biomarker roles of miR-210 in NSCLC through a comprehensive meta-analysis and an integrative bioinformatics analysis. Relevant studies were searched from several literature databases and included for qualitative synthesis based on the bivariate random-effects meta-analysis model. At the same time, we combined several bioinformatics analysis methods for exploring the potential mechanism of miR-210 involved in NSCLC. Overall, miR-210 yieled the area under curve (AUC) of 0.80 (95%CI: 0.76–0.83) with sensitivity of 0.66 (0.59–0.73) and specificity of 0.79 (0.74–0.84) for being applied to discriminate NSCLC cases from normal individuals. Besides, the combination biomarkers based on miR-210 had a higher diagnostic value accuracy than individual miR-210, with the sensitivity of 0.76 (0.72–0.79), specificity of 0.88 (0.86–0.90) and AUC of 0.91 (0.88–0.93). Through bioinformatics analysis including gene ontology, pathway enrichment, protein–protein interaction networks construction and analysis, crucial genes, pathways, modules and functional terms were identified, which were proved highly involved in the initiation and development of NSCLC. In summary, the current study suggests that miR-210 may function as a potential biomarker in NSCLC detection. Particularly, combination biomarkers may be more comprehensive indicators than single miR-210. However, the clinical diagnostic utilization and additional exploration still remain to be further tested and verified through more future studies." @default.
• W2994044994 created "2019-12-13" @default.
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• W2994044994 date "2020-03-01" @default.
• W2994044994 modified "2023-10-03" @default.
• W2994044994 title "Identification of miR-210 and combination biomarkers as useful agents in early screening non-small cell lung cancer" @default.
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• W2994044994 doi "https://doi.org/10.1016/j.gene.2019.144225" @default.
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