FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994124861> ?p ?o ?g. }

• W2994124861 endingPage "21" @default.
• W2994124861 startingPage "12" @default.
• W2994124861 abstract "Patients with ESKD who would benefit from a kidney transplant face a critical and continuing shortage of kidneys from deceased human donors. As a result, such patients wait a median of 3.9 years to receive a donor kidney, by which time approximately 35% of transplant candidates have died while waiting or have been removed from the waiting list. Those of blood group B or O may experience a significantly longer waiting period. This problem could be resolved if kidneys from genetically engineered pigs offered an alternative with an acceptable clinical outcome. Attempts to accomplish this have followed two major paths: deletion of pig xenoantigens, as well as insertion of “protective” human transgenes to counter the human immune response. Pigs with up to nine genetic manipulations are now available. In nonhuman primates, administering novel agents that block the CD40/CD154 costimulation pathway, such as an anti-CD40 mAb, suppresses the adaptive immune response, leading to pig kidney graft survival of many months without features of rejection (experiments were terminated for infectious complications). In the absence of innate and adaptive immune responses, the transplanted pig kidneys have generally displayed excellent function. A clinical trial is anticipated within 2 years. We suggest that it would be ethical to offer a pig kidney transplant to selected patients who have a life expectancy shorter than the time it would take for them to obtain a kidney from a deceased human donor. In the future, the pigs will also be genetically engineered to control the adaptive immune response, thus enabling exogenous immunosuppressive therapy to be significantly reduced or eliminated." @default.
• W2994124861 created "2019-12-13" @default.
• W2994124861 creator A5004074203 @default.
• W2994124861 creator A5021163102 @default.
• W2994124861 creator A5027326762 @default.
• W2994124861 creator A5047542433 @default.
• W2994124861 creator A5061551777 @default.
• W2994124861 creator A5064153662 @default.
• W2994124861 creator A5082539982 @default.
• W2994124861 creator A5085492854 @default.
• W2994124861 creator A5090225246 @default.
• W2994124861 creator A5090438598 @default.
• W2994124861 date "2019-12-02" @default.
• W2994124861 modified "2023-10-12" @default.
• W2994124861 title "Clinical Pig Kidney Xenotransplantation: How Close Are We?" @default.
• W2994124861 cites W1487942623 @default.
• W2994124861 cites W1543069658 @default.
• W2994124861 cites W1545215823 @default.
• W2994124861 cites W1623951127 @default.
• W2994124861 cites W165227141 @default.
• W2994124861 cites W1928404074 @default.
• W2994124861 cites W1954897628 @default.
• W2994124861 cites W1965348160 @default.
• W2994124861 cites W1966549112 @default.
• W2994124861 cites W1972229141 @default.
• W2994124861 cites W1975279687 @default.
• W2994124861 cites W1986094205 @default.
• W2994124861 cites W1992421069 @default.
• W2994124861 cites W1999227650 @default.
• W2994124861 cites W2007516625 @default.
• W2994124861 cites W2010133415 @default.
• W2994124861 cites W2015111246 @default.
• W2994124861 cites W2023654523 @default.
• W2994124861 cites W2027284410 @default.
• W2994124861 cites W2031927187 @default.
• W2994124861 cites W2033591053 @default.
• W2994124861 cites W2057607651 @default.
• W2994124861 cites W2059171126 @default.
• W2994124861 cites W2068128688 @default.
• W2994124861 cites W2072247930 @default.
• W2994124861 cites W2085878243 @default.
• W2994124861 cites W2088040832 @default.
• W2994124861 cites W2103330398 @default.
• W2994124861 cites W2109699433 @default.
• W2994124861 cites W2110553915 @default.
• W2994124861 cites W2111185199 @default.
• W2994124861 cites W2122267692 @default.
• W2994124861 cites W2124369979 @default.
• W2994124861 cites W2128925600 @default.
• W2994124861 cites W2133785873 @default.
• W2994124861 cites W2135652154 @default.
• W2994124861 cites W2146092834 @default.
• W2994124861 cites W2170715627 @default.
• W2994124861 cites W2280972418 @default.
• W2994124861 cites W2296398718 @default.
• W2994124861 cites W2315479515 @default.
• W2994124861 cites W2558447378 @default.
• W2994124861 cites W2575274634 @default.
• W2994124861 cites W2580591334 @default.
• W2994124861 cites W2595269307 @default.
• W2994124861 cites W2735827335 @default.
• W2994124861 cites W2742842976 @default.
• W2994124861 cites W2749950263 @default.
• W2994124861 cites W2780547740 @default.
• W2994124861 cites W2790909231 @default.
• W2994124861 cites W2792375564 @default.
• W2994124861 cites W2793420953 @default.
• W2994124861 cites W2798083846 @default.
• W2994124861 cites W2802356769 @default.
• W2994124861 cites W2809786479 @default.
• W2994124861 cites W2883354828 @default.
• W2994124861 cites W2891780482 @default.
• W2994124861 cites W2894772188 @default.
• W2994124861 cites W2899285249 @default.
• W2994124861 cites W2901614769 @default.
• W2994124861 cites W2902883053 @default.
• W2994124861 cites W2913452621 @default.
• W2994124861 cites W2937309785 @default.
• W2994124861 cites W2962301569 @default.
• W2994124861 cites W4233726753 @default.
• W2994124861 doi "https://doi.org/10.1681/asn.2019070651" @default.
• W2994124861 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6934994" @default.
• W2994124861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31792154" @default.
• W2994124861 hasPublicationYear "2019" @default.
• W2994124861 type Work @default.
• W2994124861 sameAs 2994124861 @default.
• W2994124861 citedByCount "46" @default.
• W2994124861 countsByYear W29941248612020 @default.
• W2994124861 countsByYear W29941248612021 @default.
• W2994124861 countsByYear W29941248612022 @default.
• W2994124861 countsByYear W29941248612023 @default.
• W2994124861 crossrefType "journal-article" @default.
• W2994124861 hasAuthorship W2994124861A5004074203 @default.
• W2994124861 hasAuthorship W2994124861A5021163102 @default.
• W2994124861 hasAuthorship W2994124861A5027326762 @default.
• W2994124861 hasAuthorship W2994124861A5047542433 @default.
• W2994124861 hasAuthorship W2994124861A5061551777 @default.
• W2994124861 hasAuthorship W2994124861A5064153662 @default.

• next