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• W2994157673 abstract "Genome-wide association studies indicate that many disease susceptibility regions reside in non-protein-coding regions of the genome. Long noncoding RNAs (lncRNAs) are a major component of the noncoding genome, but their biological impacts are not fully understood. Here, we performed a CRISPR interference (CRISPRi) screen on 2263 epidermis-expressed lncRNAs and identified nine novel candidate lncRNAs regulating keratinocyte proliferation. We further characterized a top hit from the screen, progenitor renewal associated non-coding RNA (PRANCR), using RNA interference-mediated knockdown and phenotypic analysis in organotypic human tissue. PRANCR regulates keratinocyte proliferation, cell cycle progression, and clonogenicity. PRANCR-deficient epidermis displayed impaired stratification with reduced expression of differentiation genes that are altered in human skin diseases, including keratins 1 and 10, filaggrin, and loricrin. Transcriptome analysis showed that PRANCR controls the expression of 1136 genes, with strong enrichment for late cell cycle genes containing a CHR promoter element. In addition, PRANCR depletion led to increased levels of both total and nuclear CDKN1A (also known as p21), which is known to govern both keratinocyte proliferation and differentiation. Collectively, these data show that PRANCR is a novel lncRNA regulating epidermal homeostasis and identify other lncRNA candidates that may have roles in this process as well." @default.
• W2994157673 created "2019-12-13" @default.
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• W2994157673 date "2019-12-04" @default.
• W2994157673 modified "2023-10-18" @default.
• W2994157673 title "A genome-wide long noncoding RNA CRISPRi screen identifies <i>PRANCR</i> as a novel regulator of epidermal homeostasis" @default.
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• W2994157673 doi "https://doi.org/10.1101/gr.251561.119" @default.
• W2994157673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6961571" @default.
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