FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994164077> ?p ?o ?g. }

• W2994164077 endingPage "121929" @default.
• W2994164077 startingPage "121929" @default.
• W2994164077 abstract "Steroids are essential hormones that play a crucial role in homeostasis of many biological processes including sexual development, spermatogenesis, sperm physiology and fertility. Although steroids have been largely studied in many biological matrices (such as urine and plasma), there is very limited information of the steroid content and their study as potential indicators of the quality of the seminal fluid. In this study, a LC-HRMS (liquid chromatography-high resolution mass spectrometry) strategy has been developed in order to obtain the extended steroid profile of human seminal fluid. A comparison between supported liquid extraction (SLE) and solid liquid extraction (SPE) was carried out and the chosen SPE method was further optimized to evidence the largest possible number of compounds. Steroids were automatically annotated by using DynaStI, a publicly available retention time prediction tool developed in our lab, to match the experimental data (i.e. accurate mass and tR). Altogether, these resources allowed us to develop a post-targeted approach able to consistently detect 41 steroids in seminal fluid (with half of them being androgens). Such steroid pattern was found to be stable across different extraction times and injection days. In addition to accurate mass and retention time, the identity of 70% of the steroids contained in such steroid profile was confirmed by comparing their fragmentation patterns in real samples to those of pure commercial standards. Finally, the workflow was applied to compare and distinguish the steroid profile in seminal fluid from healthy volunteers (n = 7, with one of them being a vasectomized subject). In all, the developed steroidomics strategy allows to reliably monitor an extended panel of 41 steroids in human seminal fluid." @default.
• W2994164077 created "2019-12-13" @default.
• W2994164077 creator A5002346096 @default.
• W2994164077 creator A5048923768 @default.
• W2994164077 creator A5049934475 @default.
• W2994164077 creator A5052140495 @default.
• W2994164077 creator A5057345515 @default.
• W2994164077 creator A5071473009 @default.
• W2994164077 creator A5075353003 @default.
• W2994164077 creator A5090734509 @default.
• W2994164077 date "2020-01-01" @default.
• W2994164077 modified "2023-10-16" @default.
• W2994164077 title "Steroid profile analysis by LC-HRMS in human seminal fluid" @default.
• W2994164077 cites W1530628995 @default.
• W2994164077 cites W1987237723 @default.
• W2994164077 cites W1998754189 @default.
• W2994164077 cites W2004469122 @default.
• W2994164077 cites W2011485900 @default.
• W2994164077 cites W2011956717 @default.
• W2994164077 cites W2011994682 @default.
• W2994164077 cites W2022336279 @default.
• W2994164077 cites W2037435629 @default.
• W2994164077 cites W2058417355 @default.
• W2994164077 cites W2083957193 @default.
• W2994164077 cites W2091869385 @default.
• W2994164077 cites W2094509818 @default.
• W2994164077 cites W2097516685 @default.
• W2994164077 cites W2104209753 @default.
• W2994164077 cites W2118588291 @default.
• W2994164077 cites W2126168000 @default.
• W2994164077 cites W2127194071 @default.
• W2994164077 cites W2135950441 @default.
• W2994164077 cites W2141091417 @default.
• W2994164077 cites W2145273953 @default.
• W2994164077 cites W2153335245 @default.
• W2994164077 cites W2237134196 @default.
• W2994164077 cites W2276014805 @default.
• W2994164077 cites W2327268624 @default.
• W2994164077 cites W2466798073 @default.
• W2994164077 cites W2485265936 @default.
• W2994164077 cites W2591886150 @default.
• W2994164077 cites W2592452345 @default.
• W2994164077 cites W2606282565 @default.
• W2994164077 cites W2761732367 @default.
• W2994164077 cites W2765684183 @default.
• W2994164077 cites W2779443141 @default.
• W2994164077 cites W2789470432 @default.
• W2994164077 cites W2793734804 @default.
• W2994164077 cites W2793893761 @default.
• W2994164077 cites W2809917178 @default.
• W2994164077 cites W2881236385 @default.
• W2994164077 cites W2941108043 @default.
• W2994164077 cites W2943811789 @default.
• W2994164077 cites W2960176468 @default.
• W2994164077 cites W851223685 @default.
• W2994164077 doi "https://doi.org/10.1016/j.jchromb.2019.121929" @default.
• W2994164077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31841978" @default.
• W2994164077 hasPublicationYear "2020" @default.
• W2994164077 type Work @default.
• W2994164077 sameAs 2994164077 @default.
• W2994164077 citedByCount "13" @default.
• W2994164077 countsByYear W29941640772020 @default.
• W2994164077 countsByYear W29941640772021 @default.
• W2994164077 countsByYear W29941640772022 @default.
• W2994164077 countsByYear W29941640772023 @default.
• W2994164077 crossrefType "journal-article" @default.
• W2994164077 hasAuthorship W2994164077A5002346096 @default.
• W2994164077 hasAuthorship W2994164077A5048923768 @default.
• W2994164077 hasAuthorship W2994164077A5049934475 @default.
• W2994164077 hasAuthorship W2994164077A5052140495 @default.
• W2994164077 hasAuthorship W2994164077A5057345515 @default.
• W2994164077 hasAuthorship W2994164077A5071473009 @default.
• W2994164077 hasAuthorship W2994164077A5075353003 @default.
• W2994164077 hasAuthorship W2994164077A5090734509 @default.
• W2994164077 hasConcept C126322002 @default.
• W2994164077 hasConcept C162356407 @default.
• W2994164077 hasConcept C185592680 @default.
• W2994164077 hasConcept C2776888042 @default.
• W2994164077 hasConcept C2780026642 @default.
• W2994164077 hasConcept C2780902042 @default.
• W2994164077 hasConcept C31827203 @default.
• W2994164077 hasConcept C43617362 @default.
• W2994164077 hasConcept C4725764 @default.
• W2994164077 hasConcept C55493867 @default.
• W2994164077 hasConcept C64489805 @default.
• W2994164077 hasConcept C71315377 @default.
• W2994164077 hasConcept C71924100 @default.
• W2994164077 hasConcept C81426234 @default.
• W2994164077 hasConceptScore W2994164077C126322002 @default.
• W2994164077 hasConceptScore W2994164077C162356407 @default.
• W2994164077 hasConceptScore W2994164077C185592680 @default.
• W2994164077 hasConceptScore W2994164077C2776888042 @default.
• W2994164077 hasConceptScore W2994164077C2780026642 @default.
• W2994164077 hasConceptScore W2994164077C2780902042 @default.
• W2994164077 hasConceptScore W2994164077C31827203 @default.
• W2994164077 hasConceptScore W2994164077C43617362 @default.
• W2994164077 hasConceptScore W2994164077C4725764 @default.
• W2994164077 hasConceptScore W2994164077C55493867 @default.

• next