Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994168096> ?p ?o ?g. }
- W2994168096 endingPage "1292" @default.
- W2994168096 startingPage "1284" @default.
- W2994168096 abstract "The purpose of the study was to prepare a poly-γ-glutamic acid hydrogel (PGA gel), to evaluate physicochemical properties, its ease of swallowing using texture profile analysis (TPA) and its taste-masking effects on amlodipine besylate (AML) using the artificial taste sensor and human gustatory sensation testing. Using TPA, 0.5 and 1.0% (w/v) PGA gels in the absence of drug were within the range of acceptability for use in people with difficulty swallowing according to permission criteria published by the Japanese Consumers Affairs Agency. The elution of AML from prepared PGA gels was complete within an hour and the gel did not appear to influence the bioavailability of AML. The sensor output of the basic bitterness sensor AN0 in response to AML mixed with 0.5 and 1.0% PGA gels was suppressed to a significantly greater degree than AML mixed with 0.5 and 1.0% agar. In human gustatory sensation testing, 0.5 and 1.0% PGA gels containing AML showed a potent bitterness-suppressing effect. Finally, 1H-NMR spectroscopic analysis was carried out to examine the mechanism of bitterness suppression when AML was mixed with PGA gel. The signals of the proton nearest to the nitrogen atom of AML shifted clearly upfield, suggesting an interaction between the amino group of AML and the carboxyl group of PGA gel. In conclusion, PGA gel is expected to be a useful excipient in formulations of AML, not only increasing ease of swallowing but also masking the bitterness of the basic drug." @default.
- W2994168096 created "2019-12-13" @default.
- W2994168096 creator A5000715722 @default.
- W2994168096 creator A5012236136 @default.
- W2994168096 creator A5021953699 @default.
- W2994168096 creator A5028011814 @default.
- W2994168096 creator A5062612010 @default.
- W2994168096 creator A5063675465 @default.
- W2994168096 creator A5075980955 @default.
- W2994168096 creator A5084992692 @default.
- W2994168096 date "2019-12-01" @default.
- W2994168096 modified "2023-10-16" @default.
- W2994168096 title "Preparation and Evaluation of Poly-γ-glutamic Acid Hydrogel Mixtures with Amlodipine Besylate: Effect on Ease of Swallowing and Taste Masking" @default.
- W2994168096 cites W1546644551 @default.
- W2994168096 cites W1869285760 @default.
- W2994168096 cites W1970365340 @default.
- W2994168096 cites W1974376728 @default.
- W2994168096 cites W1977816746 @default.
- W2994168096 cites W1981523368 @default.
- W2994168096 cites W1984074531 @default.
- W2994168096 cites W1986131583 @default.
- W2994168096 cites W1991898701 @default.
- W2994168096 cites W2000319012 @default.
- W2994168096 cites W2012489268 @default.
- W2994168096 cites W2016085394 @default.
- W2994168096 cites W2016227201 @default.
- W2994168096 cites W2024827120 @default.
- W2994168096 cites W2041109956 @default.
- W2994168096 cites W2059429358 @default.
- W2994168096 cites W2065878163 @default.
- W2994168096 cites W2081364727 @default.
- W2994168096 cites W2084227358 @default.
- W2994168096 cites W2084638825 @default.
- W2994168096 cites W2089275244 @default.
- W2994168096 cites W2092617167 @default.
- W2994168096 cites W2100730795 @default.
- W2994168096 cites W2154544058 @default.
- W2994168096 cites W2163644873 @default.
- W2994168096 cites W2191004072 @default.
- W2994168096 cites W2229831824 @default.
- W2994168096 cites W2332503963 @default.
- W2994168096 cites W2427396123 @default.
- W2994168096 cites W2583501608 @default.
- W2994168096 cites W2585172729 @default.
- W2994168096 cites W2776735955 @default.
- W2994168096 cites W2943238201 @default.
- W2994168096 cites W2230106865 @default.
- W2994168096 doi "https://doi.org/10.1248/cpb.c19-00548" @default.
- W2994168096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31787655" @default.
- W2994168096 hasPublicationYear "2019" @default.
- W2994168096 type Work @default.
- W2994168096 sameAs 2994168096 @default.
- W2994168096 citedByCount "4" @default.
- W2994168096 countsByYear W29941680962022 @default.
- W2994168096 countsByYear W29941680962023 @default.
- W2994168096 crossrefType "journal-article" @default.
- W2994168096 hasAuthorship W2994168096A5000715722 @default.
- W2994168096 hasAuthorship W2994168096A5012236136 @default.
- W2994168096 hasAuthorship W2994168096A5021953699 @default.
- W2994168096 hasAuthorship W2994168096A5028011814 @default.
- W2994168096 hasAuthorship W2994168096A5062612010 @default.
- W2994168096 hasAuthorship W2994168096A5063675465 @default.
- W2994168096 hasAuthorship W2994168096A5075980955 @default.
- W2994168096 hasAuthorship W2994168096A5084992692 @default.
- W2994168096 hasBestOaLocation W29941680961 @default.
- W2994168096 hasConcept C112497637 @default.
- W2994168096 hasConcept C142724271 @default.
- W2994168096 hasConcept C185592680 @default.
- W2994168096 hasConcept C199343813 @default.
- W2994168096 hasConcept C204787440 @default.
- W2994168096 hasConcept C2776608144 @default.
- W2994168096 hasConcept C2779032678 @default.
- W2994168096 hasConcept C31903555 @default.
- W2994168096 hasConcept C43617362 @default.
- W2994168096 hasConcept C71924100 @default.
- W2994168096 hasConcept C8868529 @default.
- W2994168096 hasConcept C98274493 @default.
- W2994168096 hasConceptScore W2994168096C112497637 @default.
- W2994168096 hasConceptScore W2994168096C142724271 @default.
- W2994168096 hasConceptScore W2994168096C185592680 @default.
- W2994168096 hasConceptScore W2994168096C199343813 @default.
- W2994168096 hasConceptScore W2994168096C204787440 @default.
- W2994168096 hasConceptScore W2994168096C2776608144 @default.
- W2994168096 hasConceptScore W2994168096C2779032678 @default.
- W2994168096 hasConceptScore W2994168096C31903555 @default.
- W2994168096 hasConceptScore W2994168096C43617362 @default.
- W2994168096 hasConceptScore W2994168096C71924100 @default.
- W2994168096 hasConceptScore W2994168096C8868529 @default.
- W2994168096 hasConceptScore W2994168096C98274493 @default.
- W2994168096 hasIssue "12" @default.
- W2994168096 hasLocation W29941680961 @default.
- W2994168096 hasLocation W29941680962 @default.
- W2994168096 hasOpenAccess W2994168096 @default.
- W2994168096 hasPrimaryLocation W29941680961 @default.
- W2994168096 hasRelatedWork W1965516471 @default.
- W2994168096 hasRelatedWork W2020068303 @default.
- W2994168096 hasRelatedWork W2021424238 @default.
- W2994168096 hasRelatedWork W2066484627 @default.