Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994292607> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2994292607 endingPage "448" @default.
- W2994292607 startingPage "439" @default.
- W2994292607 abstract "Abstract The metabolism of a new synthetic opioid tetrahydrofuranylfentanyl (THF‐fentanyl) was investigated using fresh human hepatocytes. Fourteen metabolites of THF‐fentanyl, such as tetrahydrofuran ring‐opened metabolites, desphenethylated metabolites, hydroxylated metabolites, and hydroxylated and methoxylated metabolites and their glucuronides, were detected in the culture medium of hepatocytes incubated with THF‐fentanyl. Six metabolites, i.e. desphenethylated metabolite, 4′‐hydroxy‐THF‐fentanyl, β‐hydroxy‐THF‐fentanyl, 4′‐hydroxy‐3′‐methoxy‐THF‐fentanyl, ring‐opened alcohol metabolite, and ring‐opened carboxylic acid metabolite, were identified via chemically synthesized authentic standards. A ring‐opened alcohol metabolite and a ring‐opened carboxylic acid metabolite are thought to be formed by reduction or oxidation of the intermediate aldehyde, which was formed by ring‐opening of the metabolite hydroxylated at the carbon atom adjacent to the oxygen atom of the tetrahydrofuran ring. A ring‐opened carboxylic acid metabolite was the main metabolite of THF‐fentanyl based on the peak intensity." @default.
- W2994292607 created "2019-12-13" @default.
- W2994292607 creator A5001718803 @default.
- W2994292607 creator A5005766368 @default.
- W2994292607 creator A5016151535 @default.
- W2994292607 creator A5016185694 @default.
- W2994292607 creator A5041908209 @default.
- W2994292607 creator A5067306185 @default.
- W2994292607 date "2020-01-19" @default.
- W2994292607 modified "2023-09-25" @default.
- W2994292607 title "Metabolism of a new synthetic opioid tetrahydrofuranylfentanyl in fresh isolated human hepatocytes: Detection and confirmation of ring‐opened metabolites" @default.
- W2994292607 cites W1989237727 @default.
- W2994292607 cites W2022672498 @default.
- W2994292607 cites W2768922681 @default.
- W2994292607 cites W2779064698 @default.
- W2994292607 cites W2805644724 @default.
- W2994292607 cites W2910298682 @default.
- W2994292607 cites W2925779154 @default.
- W2994292607 doi "https://doi.org/10.1002/dta.2743" @default.
- W2994292607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31797567" @default.
- W2994292607 hasPublicationYear "2020" @default.
- W2994292607 type Work @default.
- W2994292607 sameAs 2994292607 @default.
- W2994292607 citedByCount "7" @default.
- W2994292607 countsByYear W29942926072020 @default.
- W2994292607 countsByYear W29942926072021 @default.
- W2994292607 countsByYear W29942926072022 @default.
- W2994292607 countsByYear W29942926072023 @default.
- W2994292607 crossrefType "journal-article" @default.
- W2994292607 hasAuthorship W2994292607A5001718803 @default.
- W2994292607 hasAuthorship W2994292607A5005766368 @default.
- W2994292607 hasAuthorship W2994292607A5016151535 @default.
- W2994292607 hasAuthorship W2994292607A5016185694 @default.
- W2994292607 hasAuthorship W2994292607A5041908209 @default.
- W2994292607 hasAuthorship W2994292607A5067306185 @default.
- W2994292607 hasConcept C161790260 @default.
- W2994292607 hasConcept C178790620 @default.
- W2994292607 hasConcept C185592680 @default.
- W2994292607 hasConcept C2776701986 @default.
- W2994292607 hasConcept C2776920199 @default.
- W2994292607 hasConcept C2777477808 @default.
- W2994292607 hasConcept C2779074116 @default.
- W2994292607 hasConcept C2780378348 @default.
- W2994292607 hasConcept C2780471494 @default.
- W2994292607 hasConcept C2781066024 @default.
- W2994292607 hasConcept C2781072394 @default.
- W2994292607 hasConcept C55493867 @default.
- W2994292607 hasConcept C62231903 @default.
- W2994292607 hasConcept C71240020 @default.
- W2994292607 hasConcept C86803240 @default.
- W2994292607 hasConcept C98274493 @default.
- W2994292607 hasConceptScore W2994292607C161790260 @default.
- W2994292607 hasConceptScore W2994292607C178790620 @default.
- W2994292607 hasConceptScore W2994292607C185592680 @default.
- W2994292607 hasConceptScore W2994292607C2776701986 @default.
- W2994292607 hasConceptScore W2994292607C2776920199 @default.
- W2994292607 hasConceptScore W2994292607C2777477808 @default.
- W2994292607 hasConceptScore W2994292607C2779074116 @default.
- W2994292607 hasConceptScore W2994292607C2780378348 @default.
- W2994292607 hasConceptScore W2994292607C2780471494 @default.
- W2994292607 hasConceptScore W2994292607C2781066024 @default.
- W2994292607 hasConceptScore W2994292607C2781072394 @default.
- W2994292607 hasConceptScore W2994292607C55493867 @default.
- W2994292607 hasConceptScore W2994292607C62231903 @default.
- W2994292607 hasConceptScore W2994292607C71240020 @default.
- W2994292607 hasConceptScore W2994292607C86803240 @default.
- W2994292607 hasConceptScore W2994292607C98274493 @default.
- W2994292607 hasIssue "4" @default.
- W2994292607 hasLocation W29942926071 @default.
- W2994292607 hasOpenAccess W2994292607 @default.
- W2994292607 hasPrimaryLocation W29942926071 @default.
- W2994292607 hasRelatedWork W1499642052 @default.
- W2994292607 hasRelatedWork W1965004251 @default.
- W2994292607 hasRelatedWork W2015918333 @default.
- W2994292607 hasRelatedWork W2018755826 @default.
- W2994292607 hasRelatedWork W2039929102 @default.
- W2994292607 hasRelatedWork W2070621599 @default.
- W2994292607 hasRelatedWork W2093157753 @default.
- W2994292607 hasRelatedWork W2950400312 @default.
- W2994292607 hasRelatedWork W4240803232 @default.
- W2994292607 hasRelatedWork W561823895 @default.
- W2994292607 hasVolume "12" @default.
- W2994292607 isParatext "false" @default.
- W2994292607 isRetracted "false" @default.
- W2994292607 magId "2994292607" @default.
- W2994292607 workType "article" @default.