Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994299498> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2994299498 endingPage "77" @default.
- W2994299498 startingPage "1365" @default.
- W2994299498 abstract "Heptalysine was synthesized as a non-immunogenic carrier for artificial antigens with penicilloyl-group specificity. The synthesis was carried out by conventional techniques via different routes by condensation of appropriately protected intermediates. Best results were obtained with the use of the benzyloxycarbonyl group for intermediate protection of the alpha-amino-groups and the tert.-butyloxycarbonyl-group together with the tert.-butylester for permanent blockage of the terminal alpha-amino group, the epsilon-amino groups and the terminal carboxyl group. Heptalysine and also lysine were reacted with benzylpenicillin, alpha-aminobenzylpenicillin and tert.-butyloxycarbonyl-alpha aminobenzylpenicillin--to prevent the alpha-amino groups of penicillin from reacting--in aqueous solutions at pH 10.6-11.6 according to Levine and Redmond. The products were isolated after precipitation with acid or dialysation against water by lyophilisation. The penicilloyl group content of the conjugates as estimated from elemental analysis, penamaldate tests and the NMR spectra proved to be rather high: 5-7 residues/mol." @default.
- W2994299498 created "2019-12-13" @default.
- W2994299498 creator A5035288556 @default.
- W2994299498 date "1976-12-01" @default.
- W2994299498 modified "2023-09-23" @default.
- W2994299498 title "[Synthesis of conjugates of heptalysine and penicillins (author's transl)]." @default.
- W2994299498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/992563" @default.
- W2994299498 hasPublicationYear "1976" @default.
- W2994299498 type Work @default.
- W2994299498 sameAs 2994299498 @default.
- W2994299498 citedByCount "0" @default.
- W2994299498 crossrefType "journal-article" @default.
- W2994299498 hasAuthorship W2994299498A5035288556 @default.
- W2994299498 hasConcept C134306372 @default.
- W2994299498 hasConcept C174802600 @default.
- W2994299498 hasConcept C178790620 @default.
- W2994299498 hasConcept C185592680 @default.
- W2994299498 hasConcept C197336794 @default.
- W2994299498 hasConcept C2776016237 @default.
- W2994299498 hasConcept C2776341680 @default.
- W2994299498 hasConcept C2779746882 @default.
- W2994299498 hasConcept C2780263894 @default.
- W2994299498 hasConcept C2781311116 @default.
- W2994299498 hasConcept C33923547 @default.
- W2994299498 hasConcept C501593827 @default.
- W2994299498 hasConcept C515207424 @default.
- W2994299498 hasConcept C55493867 @default.
- W2994299498 hasConcept C71240020 @default.
- W2994299498 hasConceptScore W2994299498C134306372 @default.
- W2994299498 hasConceptScore W2994299498C174802600 @default.
- W2994299498 hasConceptScore W2994299498C178790620 @default.
- W2994299498 hasConceptScore W2994299498C185592680 @default.
- W2994299498 hasConceptScore W2994299498C197336794 @default.
- W2994299498 hasConceptScore W2994299498C2776016237 @default.
- W2994299498 hasConceptScore W2994299498C2776341680 @default.
- W2994299498 hasConceptScore W2994299498C2779746882 @default.
- W2994299498 hasConceptScore W2994299498C2780263894 @default.
- W2994299498 hasConceptScore W2994299498C2781311116 @default.
- W2994299498 hasConceptScore W2994299498C33923547 @default.
- W2994299498 hasConceptScore W2994299498C501593827 @default.
- W2994299498 hasConceptScore W2994299498C515207424 @default.
- W2994299498 hasConceptScore W2994299498C55493867 @default.
- W2994299498 hasConceptScore W2994299498C71240020 @default.
- W2994299498 hasIssue "10" @default.
- W2994299498 hasLocation W29942994981 @default.
- W2994299498 hasOpenAccess W2994299498 @default.
- W2994299498 hasPrimaryLocation W29942994981 @default.
- W2994299498 hasRelatedWork W1008111876 @default.
- W2994299498 hasRelatedWork W151475998 @default.
- W2994299498 hasRelatedWork W1973173724 @default.
- W2994299498 hasRelatedWork W2013040205 @default.
- W2994299498 hasRelatedWork W2047650966 @default.
- W2994299498 hasRelatedWork W2141459144 @default.
- W2994299498 hasRelatedWork W2413307866 @default.
- W2994299498 hasRelatedWork W2950001632 @default.
- W2994299498 hasRelatedWork W2950816001 @default.
- W2994299498 hasRelatedWork W4234911512 @default.
- W2994299498 hasVolume "357" @default.
- W2994299498 isParatext "false" @default.
- W2994299498 isRetracted "false" @default.
- W2994299498 magId "2994299498" @default.
- W2994299498 workType "article" @default.