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- W2994348567 endingPage "100038" @default.
- W2994348567 startingPage "100038" @default.
- W2994348567 abstract "The evolution of peripheral and central changes following a peripheral nerve injury imply the onset of afferent signals that affect the brain. Changes to inflammatory processes may contribute to peripheral and central alterations such as altered psychological state and are not well characterized in humans. We focused on four elements that change peripheral and central nervous systems following ankle injury in 24 adolescent patients and 12 age-sex matched controls. Findings include (a) Changes in tibial, fibular, and sciatic nerve divisions consistent with neurodegeneration; (b) Changes within the primary motor and somatosensory areas as well as higher order brain regions implicated in pain processing; (c) Increased expression of fear of pain and pain reporting; and (d) Significant changes in cytokine profiles relating to neuroinflammatory signaling pathways. Findings address how changes resulting from peripheral nerve injury may develop into chronic neuropathic pain through changes in the peripheral and central nervous system." @default.
- W2994348567 created "2019-12-13" @default.
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- W2994348567 date "2020-01-01" @default.
- W2994348567 modified "2023-10-14" @default.
- W2994348567 title "Biological and behavioral markers of pain following nerve injury in humans" @default.
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- W2994348567 doi "https://doi.org/10.1016/j.ynpai.2019.100038" @default.