Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994351444> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2994351444 endingPage "351" @default.
- W2994351444 startingPage "350" @default.
- W2994351444 abstract "Abstract Porcine epidemic diarrhea virus (PEDV) infection can occur in all ages of pigs, but neonatal piglets are the most susceptible and sensitive to the virus. PEDV infection can cause intestinal dysfunction, severe diarrhea and even death in piglets. This study determined the effects of PEDV infection on the absorptive function and gene expression of nutrient transporters in the small intestine of piglets by microarray assay. Sixteen 7-day-old healthy piglets fed with milk replacer and were randomly allocated to one of two treatments (the Control and PEDV groups). After a 5-day adaptation period, piglets (n = 8) were orally administrated with either sterile saline or PEDV (Yunnan province strain) solution at 104.5TCID50 (50% tissue culture infectious dose) per piglet. On day 5 of the trial, D-xylose (0.1 g/kg BW) was orally administrated to all piglets. One hour later, jugular vein blood samples were collected, and then all piglets were killed to obtain the intestinal samples. Compared with the control, PEDV infection increased (P < 0.05) incidence of diarrhea, plasma DAO activity and iFABP level, while decreased (P < 0.05) plasma D-xylose concentration of piglets. Moreover, PEDV infection altered the amino acids profiles (P < 0.05), and decreased (P < 0.05) the gene expression of AQPs (AQP4, AQP8 and AQP10), amino acids transporters (y+LAT1, b0’+AT, and PepT1), molecules associated with lipid transport and metabolism (LPL, SLC27A2, and ACSL3), and glucose transport and metabolism (GLUT2 and INSR). However, PEDV infection enhanced (P < 0.05) the gene epression of PCK1, ASS1, SGLT1, and CFTR in the jejunum of piglets. Collectively, these comprehensive results indicate that PEDV infection impairs intestinal absorptive function and inhibits the expression of genes associated with nutrient transport and metabolism in piglets." @default.
- W2994351444 created "2019-12-13" @default.
- W2994351444 creator A5005689660 @default.
- W2994351444 creator A5021364942 @default.
- W2994351444 creator A5030610789 @default.
- W2994351444 creator A5056807970 @default.
- W2994351444 date "2019-12-01" @default.
- W2994351444 modified "2023-09-23" @default.
- W2994351444 title "PSIX-25 Porcine epidemic diarrhea virus infection impairs intestinal nutrient transport in piglets" @default.
- W2994351444 doi "https://doi.org/10.1093/jas/skz258.698" @default.
- W2994351444 hasPublicationYear "2019" @default.
- W2994351444 type Work @default.
- W2994351444 sameAs 2994351444 @default.
- W2994351444 citedByCount "0" @default.
- W2994351444 crossrefType "journal-article" @default.
- W2994351444 hasAuthorship W2994351444A5005689660 @default.
- W2994351444 hasAuthorship W2994351444A5021364942 @default.
- W2994351444 hasAuthorship W2994351444A5030610789 @default.
- W2994351444 hasAuthorship W2994351444A5056807970 @default.
- W2994351444 hasBestOaLocation W29943514442 @default.
- W2994351444 hasConcept C126322002 @default.
- W2994351444 hasConcept C134018914 @default.
- W2994351444 hasConcept C159047783 @default.
- W2994351444 hasConcept C2522874641 @default.
- W2994351444 hasConcept C2775862345 @default.
- W2994351444 hasConcept C2777226302 @default.
- W2994351444 hasConcept C2777882243 @default.
- W2994351444 hasConcept C2779802037 @default.
- W2994351444 hasConcept C71924100 @default.
- W2994351444 hasConcept C86803240 @default.
- W2994351444 hasConceptScore W2994351444C126322002 @default.
- W2994351444 hasConceptScore W2994351444C134018914 @default.
- W2994351444 hasConceptScore W2994351444C159047783 @default.
- W2994351444 hasConceptScore W2994351444C2522874641 @default.
- W2994351444 hasConceptScore W2994351444C2775862345 @default.
- W2994351444 hasConceptScore W2994351444C2777226302 @default.
- W2994351444 hasConceptScore W2994351444C2777882243 @default.
- W2994351444 hasConceptScore W2994351444C2779802037 @default.
- W2994351444 hasConceptScore W2994351444C71924100 @default.
- W2994351444 hasConceptScore W2994351444C86803240 @default.
- W2994351444 hasIssue "Supplement_3" @default.
- W2994351444 hasLocation W29943514441 @default.
- W2994351444 hasLocation W29943514442 @default.
- W2994351444 hasOpenAccess W2994351444 @default.
- W2994351444 hasPrimaryLocation W29943514441 @default.
- W2994351444 hasRelatedWork W1487857142 @default.
- W2994351444 hasRelatedWork W1963747467 @default.
- W2994351444 hasRelatedWork W2042157784 @default.
- W2994351444 hasRelatedWork W2091870410 @default.
- W2994351444 hasRelatedWork W2118836977 @default.
- W2994351444 hasRelatedWork W2375734626 @default.
- W2994351444 hasRelatedWork W2963941227 @default.
- W2994351444 hasRelatedWork W3098054346 @default.
- W2994351444 hasRelatedWork W3150983114 @default.
- W2994351444 hasRelatedWork W3095722122 @default.
- W2994351444 hasVolume "97" @default.
- W2994351444 isParatext "false" @default.
- W2994351444 isRetracted "false" @default.
- W2994351444 magId "2994351444" @default.
- W2994351444 workType "article" @default.