FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994363728> ?p ?o ?g. }

• W2994363728 endingPage "1504" @default.
• W2994363728 startingPage "1497" @default.
• W2994363728 abstract "Background: The addition of androgen deprivation therapy to radiation therapy (RT) improves survival in patients with intermediate- and high-risk prostate cancer (PCa), but it is not known whether combined androgen blockade (CAB) with a gonadotropin-releasing hormone agonist (GnRH-A) and a nonsteroidal antiandrogen improves survival over GnRH-A monotherapy. Methods: This study evaluated patients with intermediate- and high-risk PCa diagnosed in 2001 through 2015 who underwent RT with either GnRH-A alone or CAB using the Veterans Affairs Informatics and Computing Infrastructure. Associations between CAB and prostate cancer–specific mortality (PCSM) and overall survival (OS) were determined using multivariable regression with Fine-Gray and multivariable Cox proportional hazards models, respectively. For a positive control, the effect of long-term versus short-term GnRH-A therapy was tested. Results: The cohort included 8,423 men (GnRH-A, 4,529; CAB, 3,894) with a median follow-up of 5.9 years. There were 1,861 deaths, including 349 resulting from PCa. The unadjusted cumulative incidences of PCSM at 10 years were 5.9% and 6.9% for those receiving GnRH-A and CAB, respectively ( P =.16). Compared with GnRH-A alone, CAB was not associated with a significant difference in covariate-adjusted PCSM (subdistribution hazard ratio [SHR], 1.05; 95% CI, 0.85–1.30) or OS (hazard ratio, 1.02; 95% CI, 0.93–1.12). For high-risk patients, long-term versus short-term GnRH-A therapy was associated with improved PCSM (SHR, 0.74; 95% CI, 0.57–0.95) and OS (SHR, 0.82; 95% CI, 0.73–0.93). Conclusions: In men receiving definitive RT for intermediate- or high-risk PCa, CAB was not associated with improved PCSM or OS compared with GnRH alone." @default.
• W2994363728 created "2019-12-13" @default.
• W2994363728 creator A5017049966 @default.
• W2994363728 creator A5033209069 @default.
• W2994363728 creator A5044071754 @default.
• W2994363728 creator A5047504909 @default.
• W2994363728 creator A5058325420 @default.
• W2994363728 creator A5064099533 @default.
• W2994363728 creator A5088372825 @default.
• W2994363728 creator A5089511180 @default.
• W2994363728 date "2019-12-01" @default.
• W2994363728 modified "2023-09-27" @default.
• W2994363728 title "Combined Androgen Blockade in Localized Prostate Cancer Treated With Definitive Radiation Therapy" @default.
• W2994363728 cites W1506162348 @default.
• W2994363728 cites W1972416917 @default.
• W2994363728 cites W1985587689 @default.
• W2994363728 cites W1986114421 @default.
• W2994363728 cites W1991074325 @default.
• W2994363728 cites W2000445173 @default.
• W2994363728 cites W2032649515 @default.
• W2994363728 cites W2038981426 @default.
• W2994363728 cites W2040818579 @default.
• W2994363728 cites W2081318636 @default.
• W2994363728 cites W2099594535 @default.
• W2994363728 cites W2102072512 @default.
• W2994363728 cites W2104530249 @default.
• W2994363728 cites W2108864389 @default.
• W2994363728 cites W2110534364 @default.
• W2994363728 cites W2115098571 @default.
• W2994363728 cites W2117792530 @default.
• W2994363728 cites W2125437092 @default.
• W2994363728 cites W2126176885 @default.
• W2994363728 cites W2128365260 @default.
• W2994363728 cites W2132315278 @default.
• W2994363728 cites W2137467802 @default.
• W2994363728 cites W2137996608 @default.
• W2994363728 cites W2138262494 @default.
• W2994363728 cites W2148539277 @default.
• W2994363728 cites W2148643283 @default.
• W2994363728 cites W2156456143 @default.
• W2994363728 cites W2161282696 @default.
• W2994363728 cites W2166918329 @default.
• W2994363728 cites W2620746860 @default.
• W2994363728 cites W2620798309 @default.
• W2994363728 cites W2750062392 @default.
• W2994363728 cites W2756724695 @default.
• W2994363728 cites W2904962209 @default.
• W2994363728 cites W2945522282 @default.
• W2994363728 doi "https://doi.org/10.6004/jnccn.2019.7335" @default.
• W2994363728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31805534" @default.
• W2994363728 hasPublicationYear "2019" @default.
• W2994363728 type Work @default.
• W2994363728 sameAs 2994363728 @default.
• W2994363728 citedByCount "0" @default.
• W2994363728 crossrefType "journal-article" @default.
• W2994363728 hasAuthorship W2994363728A5017049966 @default.
• W2994363728 hasAuthorship W2994363728A5033209069 @default.
• W2994363728 hasAuthorship W2994363728A5044071754 @default.
• W2994363728 hasAuthorship W2994363728A5047504909 @default.
• W2994363728 hasAuthorship W2994363728A5058325420 @default.
• W2994363728 hasAuthorship W2994363728A5064099533 @default.
• W2994363728 hasAuthorship W2994363728A5088372825 @default.
• W2994363728 hasAuthorship W2994363728A5089511180 @default.
• W2994363728 hasBestOaLocation W29943637281 @default.
• W2994363728 hasConcept C121608353 @default.
• W2994363728 hasConcept C126322002 @default.
• W2994363728 hasConcept C126894567 @default.
• W2994363728 hasConcept C143998085 @default.
• W2994363728 hasConcept C207103383 @default.
• W2994363728 hasConcept C2777899217 @default.
• W2994363728 hasConcept C2777911890 @default.
• W2994363728 hasConcept C2778043895 @default.
• W2994363728 hasConcept C2778559712 @default.
• W2994363728 hasConcept C2778575703 @default.
• W2994363728 hasConcept C2778894405 @default.
• W2994363728 hasConcept C2779093440 @default.
• W2994363728 hasConcept C2779322244 @default.
• W2994363728 hasConcept C2780192828 @default.
• W2994363728 hasConcept C29456083 @default.
• W2994363728 hasConcept C44249647 @default.
• W2994363728 hasConcept C50382708 @default.
• W2994363728 hasConcept C509974204 @default.
• W2994363728 hasConcept C71315377 @default.
• W2994363728 hasConcept C71924100 @default.
• W2994363728 hasConcept C72563966 @default.
• W2994363728 hasConceptScore W2994363728C121608353 @default.
• W2994363728 hasConceptScore W2994363728C126322002 @default.
• W2994363728 hasConceptScore W2994363728C126894567 @default.
• W2994363728 hasConceptScore W2994363728C143998085 @default.
• W2994363728 hasConceptScore W2994363728C207103383 @default.
• W2994363728 hasConceptScore W2994363728C2777899217 @default.
• W2994363728 hasConceptScore W2994363728C2777911890 @default.
• W2994363728 hasConceptScore W2994363728C2778043895 @default.
• W2994363728 hasConceptScore W2994363728C2778559712 @default.
• W2994363728 hasConceptScore W2994363728C2778575703 @default.
• W2994363728 hasConceptScore W2994363728C2778894405 @default.
• W2994363728 hasConceptScore W2994363728C2779093440 @default.
• W2994363728 hasConceptScore W2994363728C2779322244 @default.

• next