FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994367416> ?p ?o ?g. }

• W2994367416 endingPage "5671" @default.
• W2994367416 startingPage "5654" @default.
• W2994367416 abstract "Abstract Mesangioproliferative glomerulonephritis (MsPGN) is characterized by the proliferation of glomerular mesangial cells (GMCs) and accumulation of extracellular matrix (ECM), followed by glomerulosclerosis and renal failure of patients. Although our previous studies have demonstrated that sublytic C5b‐9 complex formed on the GMC membrane could trigger GMC proliferation and ECM expansion of rat Thy‐1 nephritis (Thy‐1N) as an animal model of MsPGN, their mechanisms are still not fully elucidated. In the present studies, we found that the levels of response gene to complement 32 (RGC‐32), myeloid zinc finger 1 (MZF1), phosphorylated extracellular signal‐regulated kinase 5 (phosphorylated ERK5, p‐ERK5), F‐box only protein 28 (FBXO28) and TNF receptor‐associated factor 6 (TRAF6) were all markedly up‐regulated both in the renal tissues of rats with Thy‐1N (in vivo) and in the GMCs upon sublytic C5b‐9 stimulation (in vitro). Further in vitro experiments revealed that up‐regulated FBXO28 and TRAF6 could form protein complex binding to ERK5 and enhance ERK5 K63‐ubiquitination and subsequent phosphorylation. Subsequently, ERK5 activation contributed to MZF1 expression and MZF1‐dependent RGC‐32 up‐regulation, finally resulting in GMC proliferative response. Furthermore, the MZF1‐binding element within RGC‐32 promoter and the functions of FBXO28 domains were identified. Additionally, knockdown of renal FBXO28, TRAF6, ERK5, MZF1 and RGC‐32 genes respectively markedly reduced GMC proliferation and ECM production in Thy‐1N rats. Together, these findings indicate that sublytic C5b‐9 induces GMC proliferative changes in rat Thy‐1N through ERK5/MZF1/RGC‐32 axis activated by the FBXO28‐TRAF6 complex, which might provide a new insight into MsPGN pathogenesis." @default.
• W2994367416 created "2019-12-13" @default.
• W2994367416 creator A5006782292 @default.
• W2994367416 creator A5013186907 @default.
• W2994367416 creator A5031610596 @default.
• W2994367416 creator A5038276054 @default.
• W2994367416 creator A5062617254 @default.
• W2994367416 creator A5071666770 @default.
• W2994367416 creator A5076141593 @default.
• W2994367416 creator A5079144123 @default.
• W2994367416 creator A5080337025 @default.
• W2994367416 creator A5087770835 @default.
• W2994367416 creator A5090371250 @default.
• W2994367416 creator A5090882926 @default.
• W2994367416 creator A5091516239 @default.
• W2994367416 date "2019-06-11" @default.
• W2994367416 modified "2023-10-16" @default.
• W2994367416 title "Sublytic C5b‐9 induces proliferation of glomerular mesangial cells via ERK5/MZF1/RGC‐32 axis activated by FBXO28‐TRAF6 complex" @default.
• W2994367416 cites W1498378803 @default.
• W2994367416 cites W1561217124 @default.
• W2994367416 cites W1973935351 @default.
• W2994367416 cites W1975360473 @default.
• W2994367416 cites W1975923812 @default.
• W2994367416 cites W1983194010 @default.
• W2994367416 cites W1986341898 @default.
• W2994367416 cites W1988627063 @default.
• W2994367416 cites W1988879361 @default.
• W2994367416 cites W1992643077 @default.
• W2994367416 cites W1997566993 @default.
• W2994367416 cites W1997797471 @default.
• W2994367416 cites W2014181214 @default.
• W2994367416 cites W2014803021 @default.
• W2994367416 cites W2018056155 @default.
• W2994367416 cites W2020922466 @default.
• W2994367416 cites W2026727204 @default.
• W2994367416 cites W2030307340 @default.
• W2994367416 cites W2040774362 @default.
• W2994367416 cites W2052062219 @default.
• W2994367416 cites W2059253022 @default.
• W2994367416 cites W2061537900 @default.
• W2994367416 cites W2074415549 @default.
• W2994367416 cites W2074538839 @default.
• W2994367416 cites W2074676506 @default.
• W2994367416 cites W2093304205 @default.
• W2994367416 cites W2094809025 @default.
• W2994367416 cites W2102469661 @default.
• W2994367416 cites W2149181579 @default.
• W2994367416 cites W2397047200 @default.
• W2994367416 cites W2462800709 @default.
• W2994367416 cites W2513876189 @default.
• W2994367416 cites W2520519140 @default.
• W2994367416 cites W2524435562 @default.
• W2994367416 cites W2539156819 @default.
• W2994367416 cites W2580731741 @default.
• W2994367416 cites W2594574850 @default.
• W2994367416 cites W2595075592 @default.
• W2994367416 cites W2611135576 @default.
• W2994367416 cites W2611522131 @default.
• W2994367416 cites W2621549241 @default.
• W2994367416 cites W2746034885 @default.
• W2994367416 cites W2750212851 @default.
• W2994367416 cites W2789002133 @default.
• W2994367416 cites W2791168161 @default.
• W2994367416 cites W2883512314 @default.
• W2994367416 cites W895824433 @default.
• W2994367416 doi "https://doi.org/10.1111/jcmm.14473" @default.
• W2994367416 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6653533" @default.
• W2994367416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31184423" @default.
• W2994367416 hasPublicationYear "2019" @default.
• W2994367416 type Work @default.
• W2994367416 sameAs 2994367416 @default.
• W2994367416 citedByCount "7" @default.
• W2994367416 countsByYear W29943674162020 @default.
• W2994367416 countsByYear W29943674162021 @default.
• W2994367416 countsByYear W29943674162022 @default.
• W2994367416 countsByYear W29943674162023 @default.
• W2994367416 crossrefType "journal-article" @default.
• W2994367416 hasAuthorship W2994367416A5006782292 @default.
• W2994367416 hasAuthorship W2994367416A5013186907 @default.
• W2994367416 hasAuthorship W2994367416A5031610596 @default.
• W2994367416 hasAuthorship W2994367416A5038276054 @default.
• W2994367416 hasAuthorship W2994367416A5062617254 @default.
• W2994367416 hasAuthorship W2994367416A5071666770 @default.
• W2994367416 hasAuthorship W2994367416A5076141593 @default.
• W2994367416 hasAuthorship W2994367416A5079144123 @default.
• W2994367416 hasAuthorship W2994367416A5080337025 @default.
• W2994367416 hasAuthorship W2994367416A5087770835 @default.
• W2994367416 hasAuthorship W2994367416A5090371250 @default.
• W2994367416 hasAuthorship W2994367416A5090882926 @default.
• W2994367416 hasAuthorship W2994367416A5091516239 @default.
• W2994367416 hasBestOaLocation W29943674161 @default.
• W2994367416 hasConcept C104317684 @default.
• W2994367416 hasConcept C11960822 @default.
• W2994367416 hasConcept C126322002 @default.
• W2994367416 hasConcept C134018914 @default.
• W2994367416 hasConcept C173396325 @default.
• W2994367416 hasConcept C184235292 @default.
• W2994367416 hasConcept C185592680 @default.

• next