FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994367634> ?p ?o ?g. }

• W2994367634 abstract "In the present investigation, it was explored whether food effect on drug absorption in adults is similar with the food effect after administration of an infant meal with the drug product to adults. After confirming lack of pharmaceutical and pharmacokinetic interaction, a paracetamol suspension and an ibuprofen suspension were co-administered to eight healthy adults on a crossover basis in three different occasions, i.e. in the fasted state (as defined by regulatory agencies, fasted conditions), in the fed state (as defined by regulatory agencies, fed conditions) and under conditions simulating the fed state in infants (infant fed conditions). Unlike under fed conditions, under infant fed conditions early exposure was significantly lower than under fasted conditions for both paracetamol and ibuprofen. Also, for ibuprofen, Cmax values under infant fed conditions were significantly higher than under fed conditions. These data suggest that, even for drugs with non-problematic absorption administered in simple dosage forms, food effects in infants may not be adequately evaluated if the protocol suggested by regulatory agencies is applied. The usefulness of the methodology employed in the present investigation for simulating the fed state in infants deserves further evaluation. Until then, food effects in infants should be considered cautiously or be evaluated in infants." @default.
• W2994367634 created "2019-12-13" @default.
• W2994367634 creator A5020875442 @default.
• W2994367634 creator A5038097746 @default.
• W2994367634 creator A5066208508 @default.
• W2994367634 creator A5072811095 @default.
• W2994367634 creator A5072939921 @default.
• W2994367634 creator A5078610630 @default.
• W2994367634 creator A5081839906 @default.
• W2994367634 date "2019-12-02" @default.
• W2994367634 modified "2023-10-10" @default.
• W2994367634 title "On the Design of Food Effect Studies in Adults for Extrapolating Oral Drug Absorption Data to Infants: an Exploratory Study Highlighting the Importance of Infant Food" @default.
• W2994367634 cites W115255316 @default.
• W2994367634 cites W1488850196 @default.
• W2994367634 cites W1510097375 @default.
• W2994367634 cites W1530713755 @default.
• W2994367634 cites W1539367536 @default.
• W2994367634 cites W1540807901 @default.
• W2994367634 cites W1548526678 @default.
• W2994367634 cites W1828940593 @default.
• W2994367634 cites W1967170065 @default.
• W2994367634 cites W1968118172 @default.
• W2994367634 cites W1968704145 @default.
• W2994367634 cites W1973985245 @default.
• W2994367634 cites W1977931118 @default.
• W2994367634 cites W1980766303 @default.
• W2994367634 cites W1986891507 @default.
• W2994367634 cites W1988873966 @default.
• W2994367634 cites W1992852507 @default.
• W2994367634 cites W1999502355 @default.
• W2994367634 cites W2022972688 @default.
• W2994367634 cites W2023703737 @default.
• W2994367634 cites W2032334721 @default.
• W2994367634 cites W2034861158 @default.
• W2994367634 cites W2041751579 @default.
• W2994367634 cites W2043541709 @default.
• W2994367634 cites W2054173017 @default.
• W2994367634 cites W2057182743 @default.
• W2994367634 cites W2060992818 @default.
• W2994367634 cites W2069390321 @default.
• W2994367634 cites W2072707599 @default.
• W2994367634 cites W2080480863 @default.
• W2994367634 cites W2081096348 @default.
• W2994367634 cites W2082268882 @default.
• W2994367634 cites W2082361980 @default.
• W2994367634 cites W2084079844 @default.
• W2994367634 cites W2088777183 @default.
• W2994367634 cites W2090495234 @default.
• W2994367634 cites W2095240869 @default.
• W2994367634 cites W2103790960 @default.
• W2994367634 cites W2105410889 @default.
• W2994367634 cites W2105454794 @default.
• W2994367634 cites W2110852608 @default.
• W2994367634 cites W2123439864 @default.
• W2994367634 cites W2126714190 @default.
• W2994367634 cites W2134590140 @default.
• W2994367634 cites W2143321600 @default.
• W2994367634 cites W2148150619 @default.
• W2994367634 cites W2159681899 @default.
• W2994367634 cites W2161318734 @default.
• W2994367634 cites W2162654093 @default.
• W2994367634 cites W2162723391 @default.
• W2994367634 cites W2163105200 @default.
• W2994367634 cites W2187233631 @default.
• W2994367634 cites W2260970843 @default.
• W2994367634 cites W2319334300 @default.
• W2994367634 cites W2326583289 @default.
• W2994367634 cites W2518186768 @default.
• W2994367634 cites W2557776926 @default.
• W2994367634 cites W2612735122 @default.
• W2994367634 cites W2760809818 @default.
• W2994367634 cites W2792636470 @default.
• W2994367634 cites W2810759571 @default.
• W2994367634 cites W2901755674 @default.
• W2994367634 cites W4252033603 @default.
• W2994367634 doi "https://doi.org/10.1208/s12248-019-0380-4" @default.
• W2994367634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31792743" @default.
• W2994367634 hasPublicationYear "2019" @default.
• W2994367634 type Work @default.
• W2994367634 sameAs 2994367634 @default.
• W2994367634 citedByCount "7" @default.
• W2994367634 countsByYear W29943676342020 @default.
• W2994367634 countsByYear W29943676342021 @default.
• W2994367634 countsByYear W29943676342022 @default.
• W2994367634 countsByYear W29943676342023 @default.
• W2994367634 crossrefType "journal-article" @default.
• W2994367634 hasAuthorship W2994367634A5020875442 @default.
• W2994367634 hasAuthorship W2994367634A5038097746 @default.
• W2994367634 hasAuthorship W2994367634A5066208508 @default.
• W2994367634 hasAuthorship W2994367634A5072811095 @default.
• W2994367634 hasAuthorship W2994367634A5072939921 @default.
• W2994367634 hasAuthorship W2994367634A5078610630 @default.
• W2994367634 hasAuthorship W2994367634A5081839906 @default.
• W2994367634 hasBestOaLocation W29943676341 @default.
• W2994367634 hasConcept C112705442 @default.
• W2994367634 hasConcept C121332964 @default.
• W2994367634 hasConcept C125287762 @default.
• W2994367634 hasConcept C126322002 @default.
• W2994367634 hasConcept C142724271 @default.
• W2994367634 hasConcept C187212893 @default.

• next