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- W2994408938 abstract "Objective: The present study was undertaken to evaluate the immunomodulatory activity of the alcoholic extracts of Ruta graveolens leaves in vivo.Methods: Immunomodulatory activity was determined by neutrophil adhesion test, phagocytic activity, haemagglutinating antibody (HA) titre and delayed-type hypersensitivity (DTH) response.Results: Oral administration of the extracts (50, 100, 150 and 200 mg/kg bw, p. o) evoked a significant (**P<0.01) increased in percent of neutrophil adhesion to nylon fibers. Both the extracts were also increased the antibody titre in a dose-dependent manner. Oral administration of both the compound significantly (**P<0.01) potentiated delayed type hypersensitivity reaction induced by sheep red blood cells and response towards phagocytosis in carbon clearance assay. In this study indicated that leaves extracts possesses potent immune-modulatory activity in a concentration-dependent manner. The response was statistically significant when compared with the control (*P<0.05, **P<0.01).Conclusion: The study stated that Ruta graveolens leaves extracts showed a significant stimulation of the cell-mediated immunity as well as humoral immunity. Further investigations are required to determine its active constituents and also its mechanism of action." @default.
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- W2994408938 date "2016-10-28" @default.
- W2994408938 modified "2023-09-23" @default.
- W2994408938 title "EVALUATION OF THE IMMUNOMODULATORY ACTIVITY OF THE ALCOHOLIC EXTRACTS OF RUTA GRAVEOLENS LEAVES" @default.
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- W2994408938 doi "https://doi.org/10.22159/ijpps.2016v8i11.15531" @default.
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