FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994409758> ?p ?o ?g. }

• W2994409758 endingPage "1555" @default.
• W2994409758 startingPage "1548" @default.
• W2994409758 abstract "Toxic amyloid aggregates are a feature of many neurodegenerative diseases. A number of biochemical and structural studies have demonstrated that not all amyloids of a given protein are equivalent but rather that an aggregating protein can form different amyloid structures or polymorphisms. Different polymorphisms can also induce different amounts of pathology and toxicity in cells and in mice, suggesting that the structural differences may play important roles in disease. However, the features that cause the formation of polymorphisms in vivo are still being uncovered. Posttranslational modifications on several amyloid forming proteins, including the Parkinson’s disease causing protein α-synuclein, may be one such cause. Here, we explore whether ubiquitination can induce structural changes in α-synuclein aggregates in vitro. We used protein chemistry to first synthesize ubiquitinated analogues at three different positions using disulfide linkages. After aggregation, these linkages can be reversed, allowing us to make relative comparisons between the structures using a proteinase K assay. We find that, while ubiquitination at residue 6, 23, or 96 inhibits α-synuclein aggregation, only modification at residue 96 causes an alteration in the aggregate structure, providing further evidence that posttranslational modifications may be an important feature in amyloid polymorphism formation." @default.
• W2994409758 created "2019-12-13" @default.
• W2994409758 creator A5023567689 @default.
• W2994409758 creator A5032844533 @default.
• W2994409758 creator A5048737552 @default.
• W2994409758 creator A5084496873 @default.
• W2994409758 creator A5085462355 @default.
• W2994409758 date "2019-12-06" @default.
• W2994409758 modified "2023-10-01" @default.
• W2994409758 title "Ubiquitination Can Change the Structure of the α-Synuclein Amyloid Fiber in a Site Selective Fashion" @default.
• W2994409758 cites W1594813249 @default.
• W2994409758 cites W1964788865 @default.
• W2994409758 cites W1965095016 @default.
• W2994409758 cites W1966130903 @default.
• W2994409758 cites W1967036214 @default.
• W2994409758 cites W1971116939 @default.
• W2994409758 cites W1977267085 @default.
• W2994409758 cites W1979591162 @default.
• W2994409758 cites W1983951037 @default.
• W2994409758 cites W1984678540 @default.
• W2994409758 cites W1995191747 @default.
• W2994409758 cites W2016875890 @default.
• W2994409758 cites W2022428567 @default.
• W2994409758 cites W2029479609 @default.
• W2994409758 cites W2050078112 @default.
• W2994409758 cites W2050375429 @default.
• W2994409758 cites W2074276621 @default.
• W2994409758 cites W2075793841 @default.
• W2994409758 cites W2075813074 @default.
• W2994409758 cites W2076845200 @default.
• W2994409758 cites W2083377383 @default.
• W2994409758 cites W2111216320 @default.
• W2994409758 cites W2115298392 @default.
• W2994409758 cites W2119048511 @default.
• W2994409758 cites W2119333160 @default.
• W2994409758 cites W2131222480 @default.
• W2994409758 cites W2136832023 @default.
• W2994409758 cites W2137250659 @default.
• W2994409758 cites W2152543350 @default.
• W2994409758 cites W2158977717 @default.
• W2994409758 cites W2171285101 @default.
• W2994409758 cites W2225702737 @default.
• W2994409758 cites W2312564121 @default.
• W2994409758 cites W2317462515 @default.
• W2994409758 cites W2434228301 @default.
• W2994409758 cites W2473619354 @default.
• W2994409758 cites W2521336258 @default.
• W2994409758 cites W2558819306 @default.
• W2994409758 cites W2577340531 @default.
• W2994409758 cites W2588856462 @default.
• W2994409758 cites W2682974080 @default.
• W2994409758 cites W2738605841 @default.
• W2994409758 cites W2740690576 @default.
• W2994409758 cites W2793431243 @default.
• W2994409758 cites W2885863704 @default.
• W2994409758 cites W2889082939 @default.
• W2994409758 cites W2908684845 @default.
• W2994409758 cites W2910033877 @default.
• W2994409758 cites W2924714335 @default.
• W2994409758 cites W2943553643 @default.
• W2994409758 doi "https://doi.org/10.1021/acs.joc.9b02641" @default.
• W2994409758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7097865" @default.
• W2994409758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31809571" @default.
• W2994409758 hasPublicationYear "2019" @default.
• W2994409758 type Work @default.
• W2994409758 sameAs 2994409758 @default.
• W2994409758 citedByCount "15" @default.
• W2994409758 countsByYear W29944097582020 @default.
• W2994409758 countsByYear W29944097582021 @default.
• W2994409758 countsByYear W29944097582022 @default.
• W2994409758 countsByYear W29944097582023 @default.
• W2994409758 crossrefType "journal-article" @default.
• W2994409758 hasAuthorship W2994409758A5023567689 @default.
• W2994409758 hasAuthorship W2994409758A5032844533 @default.
• W2994409758 hasAuthorship W2994409758A5048737552 @default.
• W2994409758 hasAuthorship W2994409758A5084496873 @default.
• W2994409758 hasAuthorship W2994409758A5085462355 @default.
• W2994409758 hasBestOaLocation W29944097582 @default.
• W2994409758 hasConcept C104317684 @default.
• W2994409758 hasConcept C136238340 @default.
• W2994409758 hasConcept C142724271 @default.
• W2994409758 hasConcept C179104552 @default.
• W2994409758 hasConcept C185592680 @default.
• W2994409758 hasConcept C202751555 @default.
• W2994409758 hasConcept C207001950 @default.
• W2994409758 hasConcept C25602115 @default.
• W2994409758 hasConcept C27740335 @default.
• W2994409758 hasConcept C2777633098 @default.
• W2994409758 hasConcept C2779134260 @default.
• W2994409758 hasConcept C2779734285 @default.
• W2994409758 hasConcept C2781449126 @default.
• W2994409758 hasConcept C54355233 @default.
• W2994409758 hasConcept C55493867 @default.
• W2994409758 hasConcept C71924100 @default.
• W2994409758 hasConcept C86803240 @default.
• W2994409758 hasConcept C95444343 @default.
• W2994409758 hasConceptScore W2994409758C104317684 @default.
• W2994409758 hasConceptScore W2994409758C136238340 @default.

• next