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• W2994481545 endingPage "109492" @default.
• W2994481545 startingPage "109492" @default.
• W2994481545 abstract "T cell acute lymphoblastic leukemia (T-ALL) is one of the most frequent malignancies in children, and the CXCR4 receptor plays an important role in the metastasis of this malignancy. Ghrelin is a hormone with various functions including stimulation of the release of growth hormone and autophagy in cancer cells. Moreover, SIRT1 and AMPK (AMP-activated protein kinase) stimulate expression of proteins involved in autophagy. On the other hand, autophagic cell death can be an alternative target for cancer therapy, in the absence of apoptosis. The relationship between ghrelin and the SIRT1/AMPK axis and the resulting effects on autophagy, apoptosis, proliferation, and expression of CXCR4 and the ghrelin receptor (GHS-R1a), in Jurkat and Molt-4 human lymphoblastic cell lines was not previously clear. Here we demonstrate that SIRT1 expression is upregulated during the induction of autophagy by ghrelin, an effect that is inhibited by inactivation of SIRT1/AMPK axis. In addition, ghrelin can affect CXCR4 and GHS-R1a expression. In conclusion, this work reveals that ghrelin induces autophagy, invasion, and downregulation of ghrelin receptor expression via the SIRT1/AMPK axis in lymphoblastic cell lines. However, in these cell lines ghrelin-induced autophagy does not lead to cell death due to weak induction of apoptosis. • Ghrelin upregulates SIRT1 expression during the induction of autophagy and CXCR4 in Jurkat and Molt-4 Cells. • SIRT1 is essential for ghrelin-induced autophagy in Jurkat and Molt-4 cells. • Ghrelin-induced autophagy is related to SIRT1/AMPK axis in Jurkat and Molt-4 cells. • Ghrelin receptor (GHS-R1a) expression and CXCR4 expression are related to SIRT1/AMPK axis in Jurkat and Molt-4 cells. • Ghrelin has the opposite effect on proliferation and apoptosis of Jurkat and Molt-4 cells." @default.
• W2994481545 created "2019-12-13" @default.
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• W2994481545 date "2020-02-01" @default.
• W2994481545 modified "2023-09-24" @default.
• W2994481545 title "Ghrelin induces autophagy and CXCR4 expression via the SIRT1/AMPK axis in lymphoblastic leukemia cell lines" @default.
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• W2994481545 doi "https://doi.org/10.1016/j.cellsig.2019.109492" @default.
• W2994481545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31809874" @default.
• W2994481545 hasPublicationYear "2020" @default.
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