Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994498081> ?p ?o ?g. }
- W2994498081 endingPage "222" @default.
- W2994498081 startingPage "217" @default.
- W2994498081 abstract "Objective: Macrotyloma uniflorum (Horse gram) is an important legume widely consumed in the tropical south Asian countries including India. The present investigation is the elucidation of anti-inflammatory activity of M. uniflorum as it has several medicinal properties. The M. uniflorum was evaluated for inhibition of human secretory phospholipase A 2 (sPLA 2 ) as a function of anti-inflammatory activity. Methods: The total phenols, antioxidant (DPPH scavenging), Anti-lipid peroxidation, PLA 2 inhibition and lipoxygenase (5 & 15-LOX) inhibition activity of aqueous extracts of M. uniflorum coat and pulp were assayed by in vitro method. The aqueous extract of M. uniflorum seed coat was subjected to inhibit PLA 2 enzymes from human inflammatory fluids (Human Synovial Fluid and Human Pleural Fluid) and snake venoms ( Naja naja and Vipera russllii ) using [14]C labeled E. coli by in vivo method. A further effect of substrate and calcium concentration on inhibition of VRV-PLA 2 in presence and absence of M. uniflorum coat extract were assayed. Results: Aqueous coat extract of M. uniflorum shows higher phenolics and biological activity and inhibited all sPLA 2 enzymes in concentration dependent manner. The IC 50 values are found to be in the range of 11.42-20.88μg and IC 50 values for 5-LOX and 15-LOX is 25.92μg and 32.47μg respectively. The extract effectively neutralized indirect hemolytic activity and showed similar potency in neutralizing the in vivo sPLA 2 induced mouse paw edema. Conclusion: These findings suggest that, the active compound/s in extracts of M. uniflorum individually or synergistically responsible for observed sPLA 2 inhibition." @default.
- W2994498081 created "2019-12-13" @default.
- W2994498081 creator A5000500649 @default.
- W2994498081 creator A5013364537 @default.
- W2994498081 creator A5076927867 @default.
- W2994498081 creator A5084839404 @default.
- W2994498081 creator A5043823807 @default.
- W2994498081 date "2015-12-01" @default.
- W2994498081 modified "2023-09-27" @default.
- W2994498081 title "HUMAN SECRETORY PHOSPHOLIPASE A2 (sPLA2) INHIBITION BY AQUEOUS EXTRACT OF MACROTYLOMA UNIFLORUM (SEED) AS AN ANTI-INFLAMMATORY ACTIVITY" @default.
- W2994498081 cites W1495228977 @default.
- W2994498081 cites W1510143258 @default.
- W2994498081 cites W1531257775 @default.
- W2994498081 cites W1559903407 @default.
- W2994498081 cites W1583413364 @default.
- W2994498081 cites W1590457525 @default.
- W2994498081 cites W1978173609 @default.
- W2994498081 cites W1980355522 @default.
- W2994498081 cites W1987056475 @default.
- W2994498081 cites W1989015917 @default.
- W2994498081 cites W1991423742 @default.
- W2994498081 cites W2005149171 @default.
- W2994498081 cites W2031596649 @default.
- W2994498081 cites W2031690762 @default.
- W2994498081 cites W2036092485 @default.
- W2994498081 cites W2037405899 @default.
- W2994498081 cites W2044066446 @default.
- W2994498081 cites W2048777670 @default.
- W2994498081 cites W2052412915 @default.
- W2994498081 cites W2063347675 @default.
- W2994498081 cites W2092691796 @default.
- W2994498081 cites W2108142672 @default.
- W2994498081 cites W2114471950 @default.
- W2994498081 cites W2125673865 @default.
- W2994498081 cites W2137971531 @default.
- W2994498081 cites W2139127386 @default.
- W2994498081 cites W2140414242 @default.
- W2994498081 cites W2141184580 @default.
- W2994498081 cites W2150346535 @default.
- W2994498081 cites W2151059494 @default.
- W2994498081 cites W2481467100 @default.
- W2994498081 cites W2491820742 @default.
- W2994498081 hasPublicationYear "2015" @default.
- W2994498081 type Work @default.
- W2994498081 sameAs 2994498081 @default.
- W2994498081 citedByCount "0" @default.
- W2994498081 crossrefType "journal-article" @default.
- W2994498081 hasAuthorship W2994498081A5000500649 @default.
- W2994498081 hasAuthorship W2994498081A5013364537 @default.
- W2994498081 hasAuthorship W2994498081A5043823807 @default.
- W2994498081 hasAuthorship W2994498081A5076927867 @default.
- W2994498081 hasAuthorship W2994498081A5084839404 @default.
- W2994498081 hasConcept C150903083 @default.
- W2994498081 hasConcept C181199279 @default.
- W2994498081 hasConcept C185592680 @default.
- W2994498081 hasConcept C207001950 @default.
- W2994498081 hasConcept C2777728882 @default.
- W2994498081 hasConcept C2778004101 @default.
- W2994498081 hasConcept C2779703632 @default.
- W2994498081 hasConcept C2781401929 @default.
- W2994498081 hasConcept C31903555 @default.
- W2994498081 hasConcept C55493867 @default.
- W2994498081 hasConcept C556039675 @default.
- W2994498081 hasConcept C71924100 @default.
- W2994498081 hasConcept C86803240 @default.
- W2994498081 hasConcept C98274493 @default.
- W2994498081 hasConceptScore W2994498081C150903083 @default.
- W2994498081 hasConceptScore W2994498081C181199279 @default.
- W2994498081 hasConceptScore W2994498081C185592680 @default.
- W2994498081 hasConceptScore W2994498081C207001950 @default.
- W2994498081 hasConceptScore W2994498081C2777728882 @default.
- W2994498081 hasConceptScore W2994498081C2778004101 @default.
- W2994498081 hasConceptScore W2994498081C2779703632 @default.
- W2994498081 hasConceptScore W2994498081C2781401929 @default.
- W2994498081 hasConceptScore W2994498081C31903555 @default.
- W2994498081 hasConceptScore W2994498081C55493867 @default.
- W2994498081 hasConceptScore W2994498081C556039675 @default.
- W2994498081 hasConceptScore W2994498081C71924100 @default.
- W2994498081 hasConceptScore W2994498081C86803240 @default.
- W2994498081 hasConceptScore W2994498081C98274493 @default.
- W2994498081 hasIssue "13" @default.
- W2994498081 hasLocation W29944980811 @default.
- W2994498081 hasOpenAccess W2994498081 @default.
- W2994498081 hasPrimaryLocation W29944980811 @default.
- W2994498081 hasRelatedWork W1558168237 @default.
- W2994498081 hasRelatedWork W1818076519 @default.
- W2994498081 hasRelatedWork W1986240702 @default.
- W2994498081 hasRelatedWork W1989015917 @default.
- W2994498081 hasRelatedWork W2011199541 @default.
- W2994498081 hasRelatedWork W2011817384 @default.
- W2994498081 hasRelatedWork W2014850672 @default.
- W2994498081 hasRelatedWork W2034058801 @default.
- W2994498081 hasRelatedWork W2041864929 @default.
- W2994498081 hasRelatedWork W2147968307 @default.
- W2994498081 hasRelatedWork W2169800886 @default.
- W2994498081 hasRelatedWork W2183482284 @default.
- W2994498081 hasRelatedWork W2205530586 @default.
- W2994498081 hasRelatedWork W2342116162 @default.