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- W2994554326 endingPage "118912" @default.
- W2994554326 startingPage "118912" @default.
- W2994554326 abstract "Drug-loaded thermosensitive liposomes are investigated as drug delivery systems in combination with local mild hyperthermia therapy due to their capacity to release their cargo at a specific temperature range (40–42 °C). Additional benefit can be achieved by the development of such systems that combine two different anticancer drugs, have cell penetration properties and, when heated, release their drug payload in a controlled fashion. To this end, liposomes were developed incorporating at low concentration (5 mol%) a number of monoalkylether phosphatidylcholine lipids, encompassing the platelet activating factor, PAF, and its analogues that induce thermoresponsiveness and have anticancer biological activity. These thermoresponsive liposomes were efficiently (>90%) loaded with doxorubicin (DOX), and their thermal properties, stability and drug release were investigated both at 37 ◦C and at elevated temperatures. In vitro studies of the most advantageous liposomal formulation containing the methylated PAF derivative (methyl-PAF, edelfosine), an established antitumor agent, were performed on human prostate cancer cell lines. This system exhibits controlled release of DOX at 40–42 °C, enhanced cell uptake due to the presence of methyl-PAF, and improved cell viability inhibition due to the combined action of both medications." @default.
- W2994554326 created "2019-12-13" @default.
- W2994554326 creator A5009351727 @default.
- W2994554326 creator A5011220101 @default.
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- W2994554326 creator A5079655040 @default.
- W2994554326 creator A5083961139 @default.
- W2994554326 creator A5091537643 @default.
- W2994554326 date "2020-01-01" @default.
- W2994554326 modified "2023-10-16" @default.
- W2994554326 title "A combination drug delivery system employing thermosensitive liposomes for enhanced cell penetration and improved in vitro efficacy" @default.
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- W2994554326 doi "https://doi.org/10.1016/j.ijpharm.2019.118912" @default.