FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994561572> ?p ?o ?g. }

• W2994561572 endingPage "2569" @default.
• W2994561572 startingPage "2561" @default.
• W2994561572 abstract "Abstract Background In adults, anti–tumor necrosis factor-α (TNF-α) therapy is associated with progression of latent tuberculosis (TB) infection (LTBI) to TB disease, but pediatric data are limited. Methods Retrospective multicenter study within the Paediatric Tuberculosis Network European Trials Group, capturing patients &lt;18 years who developed TB disease during anti–TNF-α therapy. Results Sixty-six tertiary healthcare institutions providing care for children with TB participated. Nineteen cases were identified: Crohn’s disease (n = 8; 42%) and juvenile idiopathic arthritis (n = 6; 32%) were the commonest underlying conditions. Immune-based TB screening (tuberculin skin test and/or interferon-γ release assay) was performed in 15 patients before commencing anti–TNF-α therapy but only identified 1 LTBI case; 13 patients were already receiving immunosuppressants at the time of screening. The median interval between starting anti–TNF-α therapy and TB diagnosis was 13.1 (IQR, 7.1–20.3) months. All cases presented with severe disease, predominantly miliary TB (n = 14; 78%). One case was diagnosed postmortem. TB was microbiologically confirmed in 15 cases (79%). The median duration of anti-TB treatment was 50 (IQR, 46–66) weeks. Five of 15 (33%) cases who had completed TB treatment had long-term sequelae. Conclusions LTBI screening is frequently false-negative in this patient population, likely due to immunosuppressants impairing test performance. Therefore, patients with immune-mediated diseases should be screened for LTBI at the point of diagnosis, before commencing immunosuppressive medication. Children on anti–TNF-α therapy are prone to severe TB disease and significant long-term morbidity. Those observations underscore the need for robust LTBI screening programs in this high-risk patient population, even in low-TB-prevalence settings." @default.
• W2994561572 created "2019-12-13" @default.
• W2994561572 creator A5002509516 @default.
• W2994561572 creator A5012057708 @default.
• W2994561572 creator A5013587335 @default.
• W2994561572 creator A5016860965 @default.
• W2994561572 creator A5018946600 @default.
• W2994561572 creator A5019966799 @default.
• W2994561572 creator A5030914420 @default.
• W2994561572 creator A5033473930 @default.
• W2994561572 creator A5038125228 @default.
• W2994561572 creator A5042536871 @default.
• W2994561572 creator A5043007900 @default.
• W2994561572 creator A5045822524 @default.
• W2994561572 creator A5047137005 @default.
• W2994561572 creator A5051328970 @default.
• W2994561572 creator A5057741610 @default.
• W2994561572 creator A5061988716 @default.
• W2994561572 creator A5063152811 @default.
• W2994561572 creator A5071592425 @default.
• W2994561572 creator A5073553172 @default.
• W2994561572 creator A5084494475 @default.
• W2994561572 creator A5088183235 @default.
• W2994561572 date "2019-12-04" @default.
• W2994561572 modified "2023-10-18" @default.
• W2994561572 title "Tuberculosis Disease in Children and Adolescents on Therapy With Antitumor Necrosis Factor-ɑ Agents: A Collaborative, Multicenter Paediatric Tuberculosis Network European Trials Group (ptbnet) Study" @default.
• W2994561572 cites W1982556428 @default.
• W2994561572 cites W2013634845 @default.
• W2994561572 cites W2013829686 @default.
• W2994561572 cites W2038535814 @default.
• W2994561572 cites W2038970546 @default.
• W2994561572 cites W2057364154 @default.
• W2994561572 cites W2064579829 @default.
• W2994561572 cites W2097362715 @default.
• W2994561572 cites W2101933557 @default.
• W2994561572 cites W2105335304 @default.
• W2994561572 cites W2108210947 @default.
• W2994561572 cites W2109686379 @default.
• W2994561572 cites W2125008418 @default.
• W2994561572 cites W2135974703 @default.
• W2994561572 cites W2144824470 @default.
• W2994561572 cites W2169607040 @default.
• W2994561572 cites W2181336402 @default.
• W2994561572 cites W2299413271 @default.
• W2994561572 cites W2331942910 @default.
• W2994561572 cites W2340746180 @default.
• W2994561572 cites W2407566330 @default.
• W2994561572 cites W2477831694 @default.
• W2994561572 cites W2511331115 @default.
• W2994561572 cites W2529707078 @default.
• W2994561572 cites W2584656768 @default.
• W2994561572 cites W2625491665 @default.
• W2994561572 cites W2758340430 @default.
• W2994561572 cites W2765084707 @default.
• W2994561572 cites W2767685214 @default.
• W2994561572 cites W2800810992 @default.
• W2994561572 cites W2905915579 @default.
• W2994561572 cites W2917332631 @default.
• W2994561572 cites W4210527786 @default.
• W2994561572 cites W4247845847 @default.
• W2994561572 doi "https://doi.org/10.1093/cid/ciz1138" @default.
• W2994561572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31796965" @default.
• W2994561572 hasPublicationYear "2019" @default.
• W2994561572 type Work @default.
• W2994561572 sameAs 2994561572 @default.
• W2994561572 citedByCount "18" @default.
• W2994561572 countsByYear W29945615722020 @default.
• W2994561572 countsByYear W29945615722021 @default.
• W2994561572 countsByYear W29945615722022 @default.
• W2994561572 countsByYear W29945615722023 @default.
• W2994561572 crossrefType "journal-article" @default.
• W2994561572 hasAuthorship W2994561572A5002509516 @default.
• W2994561572 hasAuthorship W2994561572A5012057708 @default.
• W2994561572 hasAuthorship W2994561572A5013587335 @default.
• W2994561572 hasAuthorship W2994561572A5016860965 @default.
• W2994561572 hasAuthorship W2994561572A5018946600 @default.
• W2994561572 hasAuthorship W2994561572A5019966799 @default.
• W2994561572 hasAuthorship W2994561572A5030914420 @default.
• W2994561572 hasAuthorship W2994561572A5033473930 @default.
• W2994561572 hasAuthorship W2994561572A5038125228 @default.
• W2994561572 hasAuthorship W2994561572A5042536871 @default.
• W2994561572 hasAuthorship W2994561572A5043007900 @default.
• W2994561572 hasAuthorship W2994561572A5045822524 @default.
• W2994561572 hasAuthorship W2994561572A5047137005 @default.
• W2994561572 hasAuthorship W2994561572A5051328970 @default.
• W2994561572 hasAuthorship W2994561572A5057741610 @default.
• W2994561572 hasAuthorship W2994561572A5061988716 @default.
• W2994561572 hasAuthorship W2994561572A5063152811 @default.
• W2994561572 hasAuthorship W2994561572A5071592425 @default.
• W2994561572 hasAuthorship W2994561572A5073553172 @default.
• W2994561572 hasAuthorship W2994561572A5084494475 @default.
• W2994561572 hasAuthorship W2994561572A5088183235 @default.
• W2994561572 hasBestOaLocation W29945615721 @default.
• W2994561572 hasConcept C126322002 @default.
• W2994561572 hasConcept C142724271 @default.
• W2994561572 hasConcept C187212893 @default.
• W2994561572 hasConcept C2776247216 @default.
• W2994561572 hasConcept C2777975735 @default.

• next