Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994565609> ?p ?o ?g. }
- W2994565609 endingPage "1947" @default.
- W2994565609 startingPage "1947" @default.
- W2994565609 abstract "Isorhapontigenin (ISO), a tetrahydroxylated stilbenoid, is an analog of resveratrol (Rsv). The various biological activities of Rsv and its derivatives have been previously reported in the context of both cancer and inflammation. However, the anti-cancer effect of ISO against breast cancer has not been well established, despite being an orally bioavailable dietary polyphenol. In this study, we determine the anti-cancer effects of ISO against breast cancer using MCF7, T47D, and MDA-MB-231 cell lines. We observed that ISO induces breast cancer cell death, cell cycle arrest, oxidative stress, and the inhibition of cell proliferation. Additionally, sphingosine kinase inhibition by ISO controlled tubulin polymerization and cancer cell growth by regulating MAPK/PI3K-mediated cell cycle arrest in MCF7 cells. Interestingly, SPHK1/2 gene silencing increased oxidative stress, cell death, and tubulin destabilization in MCF7 cells. This suggests that the anti-cancer effect of ISO can be regulated by SPHK/tubulin destabilization pathways. Overall, ISO successfully induced breast cancer cell death and cell growth arrest, suggesting this phytochemical is a better alternative for breast cancer treatment. Further studies in animal models could confirm the potency and usability of ISO over Rsv for targeting breast cancer, potentially posing an alternative candidate for improved therapy in the near future." @default.
- W2994565609 created "2019-12-13" @default.
- W2994565609 creator A5012503420 @default.
- W2994565609 creator A5016866322 @default.
- W2994565609 creator A5044288410 @default.
- W2994565609 creator A5061814504 @default.
- W2994565609 creator A5089518405 @default.
- W2994565609 creator A5089877526 @default.
- W2994565609 date "2019-12-05" @default.
- W2994565609 modified "2023-09-27" @default.
- W2994565609 title "A Stilbenoid Isorhapontigenin as a Potential Anti-Cancer Agent against Breast Cancer through Inhibiting Sphingosine Kinases/Tubulin Stabilization" @default.
- W2994565609 cites W1501764680 @default.
- W2994565609 cites W1573285375 @default.
- W2994565609 cites W1574146295 @default.
- W2994565609 cites W1710512272 @default.
- W2994565609 cites W1860436011 @default.
- W2994565609 cites W1967382795 @default.
- W2994565609 cites W1973817878 @default.
- W2994565609 cites W1982267073 @default.
- W2994565609 cites W1982753978 @default.
- W2994565609 cites W1983384428 @default.
- W2994565609 cites W1987468898 @default.
- W2994565609 cites W1996658532 @default.
- W2994565609 cites W2003522036 @default.
- W2994565609 cites W2007842741 @default.
- W2994565609 cites W2017945551 @default.
- W2994565609 cites W2018739566 @default.
- W2994565609 cites W2020671379 @default.
- W2994565609 cites W2027542963 @default.
- W2994565609 cites W2030324519 @default.
- W2994565609 cites W2030548853 @default.
- W2994565609 cites W2037299906 @default.
- W2994565609 cites W2039461396 @default.
- W2994565609 cites W2048171534 @default.
- W2994565609 cites W2056630127 @default.
- W2994565609 cites W2057355419 @default.
- W2994565609 cites W2064324342 @default.
- W2994565609 cites W2066700651 @default.
- W2994565609 cites W2075039221 @default.
- W2994565609 cites W2077160106 @default.
- W2994565609 cites W2086519275 @default.
- W2994565609 cites W2099988507 @default.
- W2994565609 cites W2109597409 @default.
- W2994565609 cites W2112479759 @default.
- W2994565609 cites W2115236595 @default.
- W2994565609 cites W2115392655 @default.
- W2994565609 cites W2119554522 @default.
- W2994565609 cites W2123563219 @default.
- W2994565609 cites W2131991437 @default.
- W2994565609 cites W2132730335 @default.
- W2994565609 cites W2137199913 @default.
- W2994565609 cites W2145194313 @default.
- W2994565609 cites W2149250424 @default.
- W2994565609 cites W2149688693 @default.
- W2994565609 cites W2155123561 @default.
- W2994565609 cites W2158770026 @default.
- W2994565609 cites W2158842878 @default.
- W2994565609 cites W2162306460 @default.
- W2994565609 cites W2171843232 @default.
- W2994565609 cites W2171901056 @default.
- W2994565609 cites W2172640301 @default.
- W2994565609 cites W2186023768 @default.
- W2994565609 cites W2194629726 @default.
- W2994565609 cites W2236070174 @default.
- W2994565609 cites W2263207463 @default.
- W2994565609 cites W2338837567 @default.
- W2994565609 cites W2342815276 @default.
- W2994565609 cites W2395237205 @default.
- W2994565609 cites W2396659319 @default.
- W2994565609 cites W2527169367 @default.
- W2994565609 cites W2534223538 @default.
- W2994565609 cites W2559764703 @default.
- W2994565609 cites W2582665368 @default.
- W2994565609 cites W2601180012 @default.
- W2994565609 cites W2601402626 @default.
- W2994565609 cites W2604885545 @default.
- W2994565609 cites W2605892587 @default.
- W2994565609 cites W2620249134 @default.
- W2994565609 cites W2623169010 @default.
- W2994565609 cites W2709112375 @default.
- W2994565609 cites W2738067292 @default.
- W2994565609 cites W2748181930 @default.
- W2994565609 cites W2749067209 @default.
- W2994565609 cites W2749964253 @default.
- W2994565609 cites W2756722785 @default.
- W2994565609 cites W2778926818 @default.
- W2994565609 cites W2789474678 @default.
- W2994565609 cites W2802171001 @default.
- W2994565609 cites W2805102087 @default.
- W2994565609 cites W2809012217 @default.
- W2994565609 cites W2883418948 @default.
- W2994565609 cites W2885801038 @default.
- W2994565609 cites W2889646458 @default.
- W2994565609 cites W2896520026 @default.
- W2994565609 cites W2905463426 @default.
- W2994565609 cites W2912668081 @default.
- W2994565609 cites W2923233055 @default.
- W2994565609 cites W2936469716 @default.