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• W2994612589 abstract "Abstract Background Nucleus Accumbens (NAc) is a vital brain region for the process of reward and stress, whereas microRNA plays a crucial role in depression pathology. However, the abnormality of NAc miRNA expression during the stress-induced depression and antidepressant treatment, as well as its biological significance, are still unknown. Methods We performed the small RNA-sequencing in NAc of rats from three groups: control, chronic unpredictable mild stress (CUMS), and CUMS with an antidepressant, Escitalopram. We applied an integrative pipeline for analyzing the miRNA expression alternation in different model groups, including differential expression analysis, co-expression analysis, as well as a subsequent pathway/network analysis to discover both miRNA alteration pattern and its biological significance. Result A total of 423 miRNAs were included in analysis.18/8 differential expressing (DE) miRNA (adjusted p < 0.05, |log2FC| > 1) were observed in controls Vs. depression/depression Vs. treatment, 2 of which are overlapping. 78% (14/18) of these miRNAs showed opposite trends of alteration in stress and treatment. Two micro RNA, miR-10b-5p and miR-214-3p, appeared to be hubs in the regulation networks and also among the top findings in both differential analyses. Using co-expression analysis, we found a functional module that strongly correlated with stress ( R = 0.96, P = 0.003), and another functional module with a moderate correlation with anhedonia ( R = 0.89, P = 0.02). We also found that predicted targets of these miRNAs were significantly enriched in the Ras signaling pathway, which is associated with both depression, anhedonia, and antidepressant treatment. Conclusion Escitalopram treatment can significantly reverse NAc miRNA abnormality induced by chronic stress. However, the novel miRNA alteration that is absent in stress pathology also emerges, which means that antidepressant treatment is unlikely to bring miRNA expression back to the same level as the controls. Also, the Ras-signaling pathway may be involved in explaining the depression disease etiology, the clinical symptom, and treatment response of stress-induced depression." @default.
• W2994612589 created "2019-12-26" @default.
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• W2994612589 date "2019-12-01" @default.
• W2994612589 modified "2023-10-16" @default.
• W2994612589 title "Expression alteration of microRNAs in Nucleus Accumbens is associated with chronic stress and antidepressant treatment in rats" @default.
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• W2994612589 cites W1981654563 @default.
• W2994612589 cites W1996154318 @default.
• W2994612589 cites W1996428696 @default.
• W2994612589 cites W2021609092 @default.
• W2994612589 cites W2022825972 @default.
• W2994612589 cites W2025689601 @default.
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• W2994612589 doi "https://doi.org/10.1186/s12911-019-0964-z" @default.
• W2994612589 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6921443" @default.
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