FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994633874> ?p ?o ?g. }

• W2994633874 endingPage "110069" @default.
• W2994633874 startingPage "110069" @default.
• W2994633874 abstract "Carbon disulfide (CS2) is regarded as a common occupational poison that is widely used in the textile industry in China. Our previous research suggests that CS2 can induce significant implantation disorders in pregnant mice; however, the specific mechanism remains unclear. Uterine conception in mice must undergo decidualization, which is the prerequisite for propitious blastocyst implantation into the endometrium. Therefore, in this study, we established models of pregnant mice to explore the toxic effects of CS2 on decidualization to elucidate the basic mechanism of implantation disorder after CS2 exposure. The uterine tissues were immediately collected according to the predetermined endpoints to measure the expression levels of IGFBP1 and PRL (markers of decidualization differentiation), IL-11 (representing the secretory function of decidual cells), AKT and pAKT by western blotting, RT-PCR, immunohistochemical staining, H&E staining and ELISA. N-carbamoyl glutamic acid (NCG) acted as an agonist of AKT to verify the upstream regulatory mechanism of decidualization disorder by CS2. The results showed that the normal reaction of decidual transformation was obviously disrupted by CS2 upon 3.5 dpc and 4.5 dpc exposure. The blastocyst did not adhere to the epithelium after 3.5 dpc-exposure and did not invade the endometrium after 4.5 dpc-exposure, resulting in its suspension in the uterine cavity, stagnation and eventual loss. The proteins expression levels were decreased by 95.2% for IGFBP1 and 76.2% for PRL at the 4.5 dpc endpoint after 3.5 dpc CS2 exposure compared with the control. Simultaneously, the mRNA and protein expression levels of IL-11 in uterine tissues were significantly reduced by CS2, and consistent decreasing trends over time were observed for IGFBP1 and PRL, compared with the control. Additionally, the ratio of pAKT/AKT protein expression was decreased by 72.2% and 94.8% at 12 h and 18 h after 3.5 dpc exposure and by 53.3% and 74.3% at 6 h and 12 h after 4.5 dpc exposure, respectively, compared with the corresponding controls. Furthermore, NCG could recover the IGFBP1 and PRL protein expression, which was increased by 27.5% and 52.3% at 4.5 dpc and 6.5 dpc, respectively, after 3.5 dpc exposure for IGFBP1 and by 30.3% at 6.5 dpc after 4.5 dpc exposure for PRL, compared with CS2 exposure alone. Collectively, this study suggested that the decidualization disorder caused by CS2 at the window of implantation in pregnant mice, which is triggered by pAKT, contributed to the implantation disorder and eventually led to embryo loss. It is worth noting that our study may provide a new perspective and reference for exploring the toxic mechanism of implantation disorder and even infertility in harmful circumstances." @default.
• W2994633874 created "2019-12-26" @default.
• W2994633874 creator A5002401422 @default.
• W2994633874 creator A5044513573 @default.
• W2994633874 creator A5046338175 @default.
• W2994633874 creator A5050984231 @default.
• W2994633874 creator A5060060173 @default.
• W2994633874 date "2020-03-01" @default.
• W2994633874 modified "2023-10-18" @default.
• W2994633874 title "Carbon disulfide induced decidualization disorder in the mice uterus at the window of implantation" @default.
• W2994633874 cites W1749161181 @default.
• W2994633874 cites W2041472706 @default.
• W2994633874 cites W2042161390 @default.
• W2994633874 cites W2107277218 @default.
• W2994633874 cites W2119975890 @default.
• W2994633874 cites W2160896514 @default.
• W2994633874 cites W2292392481 @default.
• W2994633874 cites W2306709121 @default.
• W2994633874 cites W2507412157 @default.
• W2994633874 cites W2511501358 @default.
• W2994633874 cites W2560142789 @default.
• W2994633874 cites W2565961256 @default.
• W2994633874 cites W2567353769 @default.
• W2994633874 cites W2568484994 @default.
• W2994633874 cites W2586487445 @default.
• W2994633874 cites W2593430021 @default.
• W2994633874 cites W2595990998 @default.
• W2994633874 cites W2617502523 @default.
• W2994633874 cites W2731462461 @default.
• W2994633874 cites W2772147343 @default.
• W2994633874 cites W2783826990 @default.
• W2994633874 cites W2787690371 @default.
• W2994633874 cites W2792798006 @default.
• W2994633874 cites W2804525178 @default.
• W2994633874 cites W2897849536 @default.
• W2994633874 cites W2902567280 @default.
• W2994633874 cites W2964717176 @default.
• W2994633874 cites W2970595327 @default.
• W2994633874 cites W4293247451 @default.
• W2994633874 doi "https://doi.org/10.1016/j.ecoenv.2019.110069" @default.
• W2994633874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31841894" @default.
• W2994633874 hasPublicationYear "2020" @default.
• W2994633874 type Work @default.
• W2994633874 sameAs 2994633874 @default.
• W2994633874 citedByCount "3" @default.
• W2994633874 countsByYear W29946338742021 @default.
• W2994633874 countsByYear W29946338742022 @default.
• W2994633874 countsByYear W29946338742023 @default.
• W2994633874 crossrefType "journal-article" @default.
• W2994633874 hasAuthorship W2994633874A5002401422 @default.
• W2994633874 hasAuthorship W2994633874A5044513573 @default.
• W2994633874 hasAuthorship W2994633874A5046338175 @default.
• W2994633874 hasAuthorship W2994633874A5050984231 @default.
• W2994633874 hasAuthorship W2994633874A5060060173 @default.
• W2994633874 hasConcept C126322002 @default.
• W2994633874 hasConcept C134018914 @default.
• W2994633874 hasConcept C16685009 @default.
• W2994633874 hasConcept C172680121 @default.
• W2994633874 hasConcept C185592680 @default.
• W2994633874 hasConcept C196843134 @default.
• W2994633874 hasConcept C2776953305 @default.
• W2994633874 hasConcept C2778177303 @default.
• W2994633874 hasConcept C2778316770 @default.
• W2994633874 hasConcept C2779066055 @default.
• W2994633874 hasConcept C2779234561 @default.
• W2994633874 hasConcept C2779742232 @default.
• W2994633874 hasConcept C2780197806 @default.
• W2994633874 hasConcept C2781107390 @default.
• W2994633874 hasConcept C54355233 @default.
• W2994633874 hasConcept C55493867 @default.
• W2994633874 hasConcept C62478195 @default.
• W2994633874 hasConcept C71924100 @default.
• W2994633874 hasConcept C75217442 @default.
• W2994633874 hasConcept C86803240 @default.
• W2994633874 hasConcept C87073359 @default.
• W2994633874 hasConcept C95444343 @default.
• W2994633874 hasConceptScore W2994633874C126322002 @default.
• W2994633874 hasConceptScore W2994633874C134018914 @default.
• W2994633874 hasConceptScore W2994633874C16685009 @default.
• W2994633874 hasConceptScore W2994633874C172680121 @default.
• W2994633874 hasConceptScore W2994633874C185592680 @default.
• W2994633874 hasConceptScore W2994633874C196843134 @default.
• W2994633874 hasConceptScore W2994633874C2776953305 @default.
• W2994633874 hasConceptScore W2994633874C2778177303 @default.
• W2994633874 hasConceptScore W2994633874C2778316770 @default.
• W2994633874 hasConceptScore W2994633874C2779066055 @default.
• W2994633874 hasConceptScore W2994633874C2779234561 @default.
• W2994633874 hasConceptScore W2994633874C2779742232 @default.
• W2994633874 hasConceptScore W2994633874C2780197806 @default.
• W2994633874 hasConceptScore W2994633874C2781107390 @default.
• W2994633874 hasConceptScore W2994633874C54355233 @default.
• W2994633874 hasConceptScore W2994633874C55493867 @default.
• W2994633874 hasConceptScore W2994633874C62478195 @default.
• W2994633874 hasConceptScore W2994633874C71924100 @default.
• W2994633874 hasConceptScore W2994633874C75217442 @default.
• W2994633874 hasConceptScore W2994633874C86803240 @default.
• W2994633874 hasConceptScore W2994633874C87073359 @default.
• W2994633874 hasConceptScore W2994633874C95444343 @default.

• next