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- W2994672489 abstract "Perfluoroalkyl substances (PFASs) are highly stable and ubiquitous compounds which have been used for more than 60 years in various products; however, their potential health effects have been assessed recently. This chapter summarizes the epidemiological studies regarding the associations of developmental exposure to PFASs with maternal and childhood health outcomes. We have focused on four main health outcomes as follows: fetal and postnatal growth, immunotoxicity, neurodevelopment, and endocrine system outcomes. Although there is a growing literature body in this field, there is still a limited number of prospective cohort studies mainly examining few PFAS types with short follow-up periods. Most studies found an association between PFASs and poor birth outcomes; however, the effects of PFASs on postnatal weight gain and obesity are not well addressed. Several studies reported immunotoxic effects of PFASs in children such as reduced vaccine response, and higher susceptibility to infectious diseases. However, the association with allergic diseases is not clear. Also, effects of PFASs on neurodevelopment are rather inconclusive. On the other hand, PFASs seem to dysregulate the endocrine system such as thyroid and steroid hormones. For the establishment of a causal relationship, further prospective cohort studies with repeated multiple compound exposure assessments are warranted." @default.
- W2994672489 created "2019-12-26" @default.
- W2994672489 creator A5054154742 @default.
- W2994672489 creator A5065534987 @default.
- W2994672489 date "2019-12-14" @default.
- W2994672489 modified "2023-09-23" @default.
- W2994672489 title "Effects of Developmental Exposure to Perfluoroalkyl Substances on Health Outcomes in Pregnant Women and Offspring" @default.
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