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• W2994678838 abstract "MicroRNAs (miRNAs) are integrally involved in biological and pathobiological development. Many studies have demonstrated the abnormal expression of microRNA-496 (miR-496) in various human malignant tumors. The present study was designed to investigate the functions and the underlying mechanisms of miR-496 in osteosarcoma (OS) progression. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to determine the expression of miR-496 in OS tissues and cell lines. Luciferase activity was used to confirm the interaction between miR-496 and brain derived neurotrophic factor (BDNF), a downstream gene of miR-496. RT-qPCR was also used to quantify BDNF mRNA expression, and the BDNF protein expression level was detected by western blot analysis. In addition, the Cell Counting Kit-8 (CCK-8) was used to detect cell viability. The results revealed that the level of miR-496 expression was significantly reduced in osteosarcoma tissues and cell lines. BDNF was verified to be a direct target gene of miR-496 and was found to be negatively regulated by miR-496. Overall, it was demonstrated that miR-496 inhibits osteosarcoma cell proliferation via inhibition of BDNF. Thus, the miR-496/BDNF axis may be a novel strategy for the clinical treatment of OS." @default.
• W2994678838 created "2019-12-26" @default.
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• W2994678838 date "2019-12-19" @default.
• W2994678838 modified "2023-09-27" @default.
• W2994678838 title "MicroRNA‑496 suppresses tumor cell proliferation by targeting BDNF in osteosarcoma" @default.
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• W2994678838 doi "https://doi.org/10.3892/etm.2019.8356" @default.
• W2994678838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6966205" @default.
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