FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994683002> ?p ?o ?g. }

• W2994683002 endingPage "1996" @default.
• W2994683002 startingPage "1986" @default.
• W2994683002 abstract "Abstract Background Several studies have suggested a survival benefit of neoadjuvant therapy (NAT) for pancreatic ductal adenocarcinoma (PDAC) in the pancreatic head. Data concerning NAT for PDAC located in pancreatic body or tail are lacking. Methods Post hoc analysis of an international multicenter retrospective cohort of distal pancreatectomy for PDAC in 34 centers from 11 countries (2007–2015). Patients who underwent resection after NAT were matched (1:1 ratio), using propensity scores based on baseline characteristics, to patients who underwent upfront resection. Median overall survival was compared using the stratified log-rank test. Results Among 1236 patients, 136 (11.0%) received NAT, most frequently FOLFIRINOX (25.7%). In total, 94 patients receiving NAT were matched to 94 patients undergoing upfront resection. NAT was associated with less postoperative major morbidity (Clavien–Dindo ≥ 3a, 10.6% vs. 23.4%, P = 0.020) and pancreatic fistula grade B/C (9.6% vs. 21.3%, P = 0.026). NAT did not improve overall survival [27 (95% CI 14–39) versus 31 months (95% CI 19–42), P = 0.277], as compared with upfront resection. In a sensitivity analysis of 251 patients with radiographic tumor involvement of splenic vessels, NAT ( n = 37, 14.7%) was associated with prolonged overall survival [36 (95% CI 18–53) versus 20 months (95% CI 15–24), P = 0.049], as compared with upfront resection. Conclusion In this international multicenter cohort study, NAT for resected PDAC in pancreatic body or tail was associated with less morbidity and pancreatic fistula but similar overall survival in comparison with upfront resection. Prospective studies should confirm a survival benefit of NAT in patients with PDAC and splenic vessel involvement." @default.
• W2994683002 created "2019-12-26" @default.
• W2994683002 creator A5001389547 @default.
• W2994683002 creator A5011716257 @default.
• W2994683002 creator A5012672720 @default.
• W2994683002 creator A5013484531 @default.
• W2994683002 creator A5015416945 @default.
• W2994683002 creator A5015859868 @default.
• W2994683002 creator A5018440372 @default.
• W2994683002 creator A5025062457 @default.
• W2994683002 creator A5032835526 @default.
• W2994683002 creator A5033134171 @default.
• W2994683002 creator A5036393670 @default.
• W2994683002 creator A5036872391 @default.
• W2994683002 creator A5045976588 @default.
• W2994683002 creator A5049957859 @default.
• W2994683002 creator A5056653055 @default.
• W2994683002 creator A5057380925 @default.
• W2994683002 creator A5065743678 @default.
• W2994683002 creator A5072356061 @default.
• W2994683002 creator A5088558288 @default.
• W2994683002 date "2019-12-17" @default.
• W2994683002 modified "2023-10-16" @default.
• W2994683002 title "Impact of Neoadjuvant Therapy in Resected Pancreatic Ductal Adenocarcinoma of the Pancreatic Body or Tail on Surgical and Oncological Outcome: A Propensity-Score Matched Multicenter Study" @default.
• W2994683002 cites W1971589201 @default.
• W2994683002 cites W1975891520 @default.
• W2994683002 cites W1985213644 @default.
• W2994683002 cites W1990882666 @default.
• W2994683002 cites W1994177577 @default.
• W2994683002 cites W2005718828 @default.
• W2994683002 cites W2077267963 @default.
• W2994683002 cites W2086830718 @default.
• W2994683002 cites W2088026824 @default.
• W2994683002 cites W2099329725 @default.
• W2994683002 cites W2117853299 @default.
• W2994683002 cites W2121471550 @default.
• W2994683002 cites W2122663828 @default.
• W2994683002 cites W2144173184 @default.
• W2994683002 cites W2165340137 @default.
• W2994683002 cites W2174776728 @default.
• W2994683002 cites W2275737843 @default.
• W2994683002 cites W2324797626 @default.
• W2994683002 cites W2330075233 @default.
• W2994683002 cites W2345822778 @default.
• W2994683002 cites W2520410409 @default.
• W2994683002 cites W2520770744 @default.
• W2994683002 cites W2529914163 @default.
• W2994683002 cites W2542081609 @default.
• W2994683002 cites W2766739545 @default.
• W2994683002 cites W2770950260 @default.
• W2994683002 cites W2779096740 @default.
• W2994683002 cites W2784433219 @default.
• W2994683002 cites W2791578009 @default.
• W2994683002 cites W2799575632 @default.
• W2994683002 cites W2805901850 @default.
• W2994683002 cites W2885803071 @default.
• W2994683002 cites W2886620938 @default.
• W2994683002 cites W2890497386 @default.
• W2994683002 cites W2894129474 @default.
• W2994683002 cites W2912196744 @default.
• W2994683002 cites W2917648886 @default.
• W2994683002 cites W2932498431 @default.
• W2994683002 cites W2946675602 @default.
• W2994683002 cites W2958638332 @default.
• W2994683002 cites W2969945405 @default.
• W2994683002 cites W592682419 @default.
• W2994683002 doi "https://doi.org/10.1245/s10434-019-08137-6" @default.
• W2994683002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7210228" @default.
• W2994683002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31848815" @default.
• W2994683002 hasPublicationYear "2019" @default.
• W2994683002 type Work @default.
• W2994683002 sameAs 2994683002 @default.
• W2994683002 citedByCount "26" @default.
• W2994683002 countsByYear W29946830022020 @default.
• W2994683002 countsByYear W29946830022021 @default.
• W2994683002 countsByYear W29946830022022 @default.
• W2994683002 countsByYear W29946830022023 @default.
• W2994683002 crossrefType "journal-article" @default.
• W2994683002 hasAuthorship W2994683002A5001389547 @default.
• W2994683002 hasAuthorship W2994683002A5011716257 @default.
• W2994683002 hasAuthorship W2994683002A5012672720 @default.
• W2994683002 hasAuthorship W2994683002A5013484531 @default.
• W2994683002 hasAuthorship W2994683002A5015416945 @default.
• W2994683002 hasAuthorship W2994683002A5015859868 @default.
• W2994683002 hasAuthorship W2994683002A5018440372 @default.
• W2994683002 hasAuthorship W2994683002A5025062457 @default.
• W2994683002 hasAuthorship W2994683002A5032835526 @default.
• W2994683002 hasAuthorship W2994683002A5033134171 @default.
• W2994683002 hasAuthorship W2994683002A5036393670 @default.
• W2994683002 hasAuthorship W2994683002A5036872391 @default.
• W2994683002 hasAuthorship W2994683002A5045976588 @default.
• W2994683002 hasAuthorship W2994683002A5049957859 @default.
• W2994683002 hasAuthorship W2994683002A5056653055 @default.
• W2994683002 hasAuthorship W2994683002A5057380925 @default.
• W2994683002 hasAuthorship W2994683002A5065743678 @default.
• W2994683002 hasAuthorship W2994683002A5072356061 @default.
• W2994683002 hasAuthorship W2994683002A5088558288 @default.
• W2994683002 hasBestOaLocation W29946830021 @default.

• next