Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994691634> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2994691634 endingPage "168" @default.
- W2994691634 startingPage "162" @default.
- W2994691634 abstract "This prospective, Phase 3, open-label, study (EudraCT: 2016-001631-12) evaluated pharmacokinetic (PK) characteristics of 3-/4-weekly Privigen® (IgPro10, CSL Behring, King of Prussia, PA, USA) in Japanese patients with PID. PK parameters including serum trough immunoglobulin (IgG) level before next infusion during the wash-in/wash-out phase (Ctrough), area under the concentration-time curve from time point zero to the last time point with quantifiable concentration (AUC0-last), dose-adjusted AUC0-last (dAUC), lowest and highest observed IgG levels (Cmin, Cmax), time to reach Cmax (Tmax), and total clearance (CL) were analyzed for both regimens of Privigen® (dose: 138-554 mg/kg body weight). Ten patients were included in this analysis (3-/4-weekly: n = 2/n = 8). Ctrough levels achieved ranged 7.96-10.05 g/L. Cmax was observed approximately 1 h after the start of the infusion in both regimens. Mean (SD [not applicable for 3-weekly data]) PK parameters: Cmax, 16.60 and 14.20 (5.53) g/L; Cmin, 10.60 and 8.53 (3.89) g/L; AUC0-last, 5971 and 6591 (2633) g*h/L; dAUC, 0.41 and 0.46 (0.19) g*h/L/mg; CL, 2.53 and 2.53 (1.00) mL/h and median Tmax was 1.19 and 1.14 h, for 3-/4-weekly dosing regimens, respectively. Privigen® PK characteristics in Japanese patients were similar between dosing regimens and to previously-reported results in non-Japanese patients with PID." @default.
- W2994691634 created "2019-12-26" @default.
- W2994691634 creator A5004293860 @default.
- W2994691634 creator A5009475566 @default.
- W2994691634 creator A5013142762 @default.
- W2994691634 creator A5040707258 @default.
- W2994691634 creator A5041173181 @default.
- W2994691634 date "2019-10-02" @default.
- W2994691634 modified "2023-09-25" @default.
- W2994691634 title "Pharmacokinetic properties of Privigen<sup>®</sup> in Japanese patients with primary immunodeficiency" @default.
- W2994691634 cites W1487079135 @default.
- W2994691634 cites W1582023997 @default.
- W2994691634 cites W1931185549 @default.
- W2994691634 cites W1989549126 @default.
- W2994691634 cites W2009582434 @default.
- W2994691634 cites W2014633918 @default.
- W2994691634 cites W2028769138 @default.
- W2994691634 cites W2029982282 @default.
- W2994691634 cites W2050923622 @default.
- W2994691634 cites W2065435077 @default.
- W2994691634 cites W2084801194 @default.
- W2994691634 cites W2092971383 @default.
- W2994691634 cites W2104382376 @default.
- W2994691634 cites W2117403402 @default.
- W2994691634 cites W2806591881 @default.
- W2994691634 cites W2901937413 @default.
- W2994691634 cites W2917335258 @default.
- W2994691634 cites W4237163879 @default.
- W2994691634 doi "https://doi.org/10.1080/25785826.2019.1700085" @default.
- W2994691634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31847720" @default.
- W2994691634 hasPublicationYear "2019" @default.
- W2994691634 type Work @default.
- W2994691634 sameAs 2994691634 @default.
- W2994691634 citedByCount "3" @default.
- W2994691634 countsByYear W29946916342021 @default.
- W2994691634 countsByYear W29946916342023 @default.
- W2994691634 crossrefType "journal-article" @default.
- W2994691634 hasAuthorship W2994691634A5004293860 @default.
- W2994691634 hasAuthorship W2994691634A5009475566 @default.
- W2994691634 hasAuthorship W2994691634A5013142762 @default.
- W2994691634 hasAuthorship W2994691634A5040707258 @default.
- W2994691634 hasAuthorship W2994691634A5041173181 @default.
- W2994691634 hasBestOaLocation W29946916341 @default.
- W2994691634 hasConcept C112705442 @default.
- W2994691634 hasConcept C126322002 @default.
- W2994691634 hasConcept C22979827 @default.
- W2994691634 hasConcept C2777288759 @default.
- W2994691634 hasConcept C2778335254 @default.
- W2994691634 hasConcept C2910800852 @default.
- W2994691634 hasConcept C71924100 @default.
- W2994691634 hasConcept C76318530 @default.
- W2994691634 hasConcept C90924648 @default.
- W2994691634 hasConcept C98274493 @default.
- W2994691634 hasConceptScore W2994691634C112705442 @default.
- W2994691634 hasConceptScore W2994691634C126322002 @default.
- W2994691634 hasConceptScore W2994691634C22979827 @default.
- W2994691634 hasConceptScore W2994691634C2777288759 @default.
- W2994691634 hasConceptScore W2994691634C2778335254 @default.
- W2994691634 hasConceptScore W2994691634C2910800852 @default.
- W2994691634 hasConceptScore W2994691634C71924100 @default.
- W2994691634 hasConceptScore W2994691634C76318530 @default.
- W2994691634 hasConceptScore W2994691634C90924648 @default.
- W2994691634 hasConceptScore W2994691634C98274493 @default.
- W2994691634 hasIssue "4" @default.
- W2994691634 hasLocation W29946916341 @default.
- W2994691634 hasLocation W29946916342 @default.
- W2994691634 hasOpenAccess W2994691634 @default.
- W2994691634 hasPrimaryLocation W29946916341 @default.
- W2994691634 hasRelatedWork W1896462913 @default.
- W2994691634 hasRelatedWork W1990533335 @default.
- W2994691634 hasRelatedWork W2029224554 @default.
- W2994691634 hasRelatedWork W2054172655 @default.
- W2994691634 hasRelatedWork W2151288869 @default.
- W2994691634 hasRelatedWork W2319990761 @default.
- W2994691634 hasRelatedWork W2376087219 @default.
- W2994691634 hasRelatedWork W2744917474 @default.
- W2994691634 hasRelatedWork W2914073772 @default.
- W2994691634 hasRelatedWork W3180997219 @default.
- W2994691634 hasVolume "42" @default.
- W2994691634 isParatext "false" @default.
- W2994691634 isRetracted "false" @default.
- W2994691634 magId "2994691634" @default.
- W2994691634 workType "article" @default.