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- W2994696002 abstract "Abstract The promotion of structural and functional plasticity by estrogens is a promising approach to enhance central nervous system function in the aged. However, how the sensitivity to estrogens is regulated across brain regions, age and experience is poorly understood. To ask if estradiol treatment impacts structural and functional plasticity in sensory cortices, we examined the acute effect of 17α-Estradiol in adult Long Evans rats following chronic monocular deprivation, a manipulation that reduces the strength and selectivity of deprived eye vision. Chronic monocular deprivation decreased thalamic input from the deprived eye to the binocular visual cortex and accelerated short-term depression of the deprived eye pathway, but did not change the density of excitatory synapses in primary visual cortex. Importantly, we found that the classical estrogen receptors ERα and ERβ were robustly expressed in the adult visual cortex, and that a single dose of 17α-Estradiol reduced the expression of the calcium-binding protein parvalbumin, decreased the integrity of the extracellular matrix and increased the size of excitatory postsynaptic densities. Furthermore, 17α-Estradiol enhanced experience-dependent plasticity in the amblyopic visual cortex, by promoting response potentiation of the pathway served by the non-deprived eye. The promotion of plasticity at synapses serving the non-deprived eye may reflect selectivity for synapses with an initially low probability of neurotransmitter release, and may inform strategies to remap spared inputs around a scotoma or a cortical infarct." @default.
- W2994696002 created "2019-12-26" @default.
- W2994696002 creator A5024538369 @default.
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- W2994696002 creator A5086614863 @default.
- W2994696002 date "2019-12-13" @default.
- W2994696002 modified "2023-09-26" @default.
- W2994696002 title "17α Estradiol promotes plasticity of spared inputs in the adult amblyopic visual cortex" @default.
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- W2994696002 doi "https://doi.org/10.1038/s41598-019-55158-y" @default.
- W2994696002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6910995" @default.
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- W2994696002 hasPublicationYear "2019" @default.
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