FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994697497> ?p ?o ?g. }

• W2994697497 abstract "Tuberculosis (TB) results in both morbidity and mortality on a global scale. With drug resistance on the increase, there is an urgent need to develop novel anti-mycobacterials. Thus, we assessed the anti-mycobacterial potency of three novel synthetic peptoids against drug-susceptible and multi-drug resistant (MDR) Mycobacterium tuberculosis in vitro using Minimum Inhibitory Concentration, killing efficacy and intracellular growth inhibition assays, and in vivo against mycobacteria infected BALB/c mice. In addition, we verified cell selectivity using mammalian cells to assess peptoid toxicity. The mechanism of action was determined using flow cytometric analysis, and microfluidic live-cell imaging with time-lapse microscopy and uptake of propidium iodide. Peptoid BM 2 demonstrated anti-mycobacterial activity against both drug sensitive and MDR M. tuberculosis together with an acceptable toxicity profile that showed selectivity between bacterial and mammalian membranes. The peptoid was able to efficiently kill the bacteria both in vitro and intracellularly in murine RAW 264.7 macrophages, and significantly reduced bacterial load in the lungs of infected mice. Flow cytometric and time lapse fluorescence microscopy indicate mycobacterial membrane damage as the likely mechanism of action. These data demonstrate that peptoids are a novel class of antimicrobial which warrant further investigation and development as therapeutics against TB." @default.
• W2994697497 created "2019-12-26" @default.
• W2994697497 creator A5000340256 @default.
• W2994697497 creator A5010939575 @default.
• W2994697497 creator A5012300063 @default.
• W2994697497 creator A5018271056 @default.
• W2994697497 creator A5019608185 @default.
• W2994697497 creator A5023693692 @default.
• W2994697497 creator A5060781921 @default.
• W2994697497 creator A5072699812 @default.
• W2994697497 date "2020-03-17" @default.
• W2994697497 modified "2023-10-12" @default.
• W2994697497 title "Ultra-Short Antimicrobial Peptoids Show Propensity for Membrane Activity Against Multi-Drug Resistant Mycobacterium tuberculosis" @default.
• W2994697497 cites W1484992502 @default.
• W2994697497 cites W1590554107 @default.
• W2994697497 cites W1969711244 @default.
• W2994697497 cites W1986106712 @default.
• W2994697497 cites W1993906884 @default.
• W2994697497 cites W1997152791 @default.
• W2994697497 cites W2024149989 @default.
• W2994697497 cites W2024793975 @default.
• W2994697497 cites W2026498982 @default.
• W2994697497 cites W2059390726 @default.
• W2994697497 cites W2066271990 @default.
• W2994697497 cites W2113657296 @default.
• W2994697497 cites W2120391251 @default.
• W2994697497 cites W2128423408 @default.
• W2994697497 cites W2139931131 @default.
• W2994697497 cites W2142759234 @default.
• W2994697497 cites W2156995597 @default.
• W2994697497 cites W2170448556 @default.
• W2994697497 cites W2252622713 @default.
• W2994697497 cites W2344048819 @default.
• W2994697497 cites W2346518485 @default.
• W2994697497 cites W2516194775 @default.
• W2994697497 cites W2565686633 @default.
• W2994697497 cites W2567713795 @default.
• W2994697497 cites W2585044801 @default.
• W2994697497 cites W2588689309 @default.
• W2994697497 cites W2594630574 @default.
• W2994697497 cites W2805761887 @default.
• W2994697497 cites W2898925933 @default.
• W2994697497 cites W2915574559 @default.
• W2994697497 cites W4235106149 @default.
• W2994697497 doi "https://doi.org/10.3389/fmicb.2020.00417" @default.
• W2994697497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7089965" @default.
• W2994697497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32256474" @default.
• W2994697497 hasPublicationYear "2020" @default.
• W2994697497 type Work @default.
• W2994697497 sameAs 2994697497 @default.
• W2994697497 citedByCount "16" @default.
• W2994697497 countsByYear W29946974972020 @default.
• W2994697497 countsByYear W29946974972021 @default.
• W2994697497 countsByYear W29946974972022 @default.
• W2994697497 countsByYear W29946974972023 @default.
• W2994697497 crossrefType "journal-article" @default.
• W2994697497 hasAuthorship W2994697497A5000340256 @default.
• W2994697497 hasAuthorship W2994697497A5010939575 @default.
• W2994697497 hasAuthorship W2994697497A5012300063 @default.
• W2994697497 hasAuthorship W2994697497A5018271056 @default.
• W2994697497 hasAuthorship W2994697497A5019608185 @default.
• W2994697497 hasAuthorship W2994697497A5023693692 @default.
• W2994697497 hasAuthorship W2994697497A5060781921 @default.
• W2994697497 hasAuthorship W2994697497A5072699812 @default.
• W2994697497 hasBestOaLocation W29946974971 @default.
• W2994697497 hasConcept C114851261 @default.
• W2994697497 hasConcept C142724271 @default.
• W2994697497 hasConcept C150903083 @default.
• W2994697497 hasConcept C185592680 @default.
• W2994697497 hasConcept C190283241 @default.
• W2994697497 hasConcept C202751555 @default.
• W2994697497 hasConcept C207001950 @default.
• W2994697497 hasConcept C2775934118 @default.
• W2994697497 hasConcept C2777975735 @default.
• W2994697497 hasConcept C2779281246 @default.
• W2994697497 hasConcept C2780035454 @default.
• W2994697497 hasConcept C2780474982 @default.
• W2994697497 hasConcept C2781069245 @default.
• W2994697497 hasConcept C31573885 @default.
• W2994697497 hasConcept C4937899 @default.
• W2994697497 hasConcept C55493867 @default.
• W2994697497 hasConcept C71924100 @default.
• W2994697497 hasConcept C86803240 @default.
• W2994697497 hasConcept C89423630 @default.
• W2994697497 hasConcept C98274493 @default.
• W2994697497 hasConceptScore W2994697497C114851261 @default.
• W2994697497 hasConceptScore W2994697497C142724271 @default.
• W2994697497 hasConceptScore W2994697497C150903083 @default.
• W2994697497 hasConceptScore W2994697497C185592680 @default.
• W2994697497 hasConceptScore W2994697497C190283241 @default.
• W2994697497 hasConceptScore W2994697497C202751555 @default.
• W2994697497 hasConceptScore W2994697497C207001950 @default.
• W2994697497 hasConceptScore W2994697497C2775934118 @default.
• W2994697497 hasConceptScore W2994697497C2777975735 @default.
• W2994697497 hasConceptScore W2994697497C2779281246 @default.
• W2994697497 hasConceptScore W2994697497C2780035454 @default.
• W2994697497 hasConceptScore W2994697497C2780474982 @default.
• W2994697497 hasConceptScore W2994697497C2781069245 @default.
• W2994697497 hasConceptScore W2994697497C31573885 @default.
• W2994697497 hasConceptScore W2994697497C4937899 @default.

• next