FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994702617> ?p ?o ?g. }

• W2994702617 endingPage "274" @default.
• W2994702617 startingPage "265" @default.
• W2994702617 abstract "Nasopharyngeal carcinoma ( NPC ) is a common cancer found in the nasopharynx with high metastatic and invasive nature. Increasing evidences have identified the critical role of gene therapy in NPC treatment. Hence, this study was designed to identify specific gene markers that affected NPC progression through gene expression profile analysis. NPC ‐related gene expression data set gene set enrichment ( GSE )53819 were retrieved and analyzed to screen out differentially expressed genes ( DEG s), followed by determination of their expression in noncancerous tissues and NPC specimens. Next, weighted gene co‐expression network analysis ( WGCNA ) was conducted on DEG s to obtain tumor‐associated gene modules. Genes in those modules were intersected with DEG s for gene ontology and Kyoto Encyclopedia of Genes and Genomes functional enrichment analysis. Then protein‐protein interaction network of tumor‐associated genes was constructed to select genes most closely linked to NPC . Afterward, expression of chromosome 9 open reading frame 24 (c9orf24), primary ciliary dyskinesia protein 1 ( PCDP 1), and leucine‐rich repeat‐containing protein 46 ( LRRC 46) was detected in GSE 53819 and further verified in GSE 12452 and GSE 64634. Differential analysis on GSE 53819 found that 2,173 genes were aberrantly expressed in NPC , among which 917 genes are upregulated and 1,256 genes are downregulated. WGCNA showed that genes were enriched in 17 modules and 727 genes exhibited ectopic expression in NPC and enriched in cytokine‐cytokine receptor interaction, cytochrome P450, and chemical carcinogenesis signaling pathways, among which c9orf24, PCDP 1, and LRRC 46 were poorly expressed in NPC . Therefore, c9orf24, PCDP 1, and LRRC 46 might serve as prominent diagnostic markers for NPC , which presents new insights for NPC therapy." @default.
• W2994702617 created "2019-12-26" @default.
• W2994702617 creator A5025314440 @default.
• W2994702617 creator A5030431816 @default.
• W2994702617 creator A5042436711 @default.
• W2994702617 creator A5068949602 @default.
• W2994702617 creator A5070771458 @default.
• W2994702617 creator A5086602793 @default.
• W2994702617 creator A5087537091 @default.
• W2994702617 date "2019-12-21" @default.
• W2994702617 modified "2023-10-13" @default.
• W2994702617 title "Identification of Potential Therapeutic Gene Markers in Nasopharyngeal Carcinoma Based on Bioinformatics Analysis" @default.
• W2994702617 cites W1967727795 @default.
• W2994702617 cites W1978214951 @default.
• W2994702617 cites W2000767414 @default.
• W2994702617 cites W2018016054 @default.
• W2994702617 cites W2022260265 @default.
• W2994702617 cites W2023880040 @default.
• W2994702617 cites W2035618305 @default.
• W2994702617 cites W2046899485 @default.
• W2994702617 cites W2059243506 @default.
• W2994702617 cites W2072145718 @default.
• W2994702617 cites W2098212097 @default.
• W2994702617 cites W2108818515 @default.
• W2994702617 cites W2110157421 @default.
• W2994702617 cites W2111299999 @default.
• W2994702617 cites W2131465172 @default.
• W2994702617 cites W2131577336 @default.
• W2994702617 cites W2135168024 @default.
• W2994702617 cites W2144594291 @default.
• W2994702617 cites W2150434794 @default.
• W2994702617 cites W2164860987 @default.
• W2994702617 cites W2166628699 @default.
• W2994702617 cites W2170395380 @default.
• W2994702617 cites W2310018175 @default.
• W2994702617 cites W2313799281 @default.
• W2994702617 cites W2436809673 @default.
• W2994702617 cites W2471647970 @default.
• W2994702617 cites W2482883934 @default.
• W2994702617 cites W2513974085 @default.
• W2994702617 cites W2523768268 @default.
• W2994702617 cites W2551728117 @default.
• W2994702617 cites W2589336977 @default.
• W2994702617 cites W2609362074 @default.
• W2994702617 cites W2623868336 @default.
• W2994702617 cites W2736605898 @default.
• W2994702617 cites W2748552337 @default.
• W2994702617 cites W2791387781 @default.
• W2994702617 cites W2920771602 @default.
• W2994702617 cites W4240598249 @default.
• W2994702617 cites W4243624030 @default.
• W2994702617 cites W4251333818 @default.
• W2994702617 cites W4293384264 @default.
• W2994702617 cites W4294329053 @default.
• W2994702617 doi "https://doi.org/10.1111/cts.12690" @default.
• W2994702617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7070980" @default.
• W2994702617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31863646" @default.
• W2994702617 hasPublicationYear "2019" @default.
• W2994702617 type Work @default.
• W2994702617 sameAs 2994702617 @default.
• W2994702617 citedByCount "6" @default.
• W2994702617 countsByYear W29947026172020 @default.
• W2994702617 countsByYear W29947026172021 @default.
• W2994702617 countsByYear W29947026172022 @default.
• W2994702617 crossrefType "journal-article" @default.
• W2994702617 hasAuthorship W2994702617A5025314440 @default.
• W2994702617 hasAuthorship W2994702617A5030431816 @default.
• W2994702617 hasAuthorship W2994702617A5042436711 @default.
• W2994702617 hasAuthorship W2994702617A5068949602 @default.
• W2994702617 hasAuthorship W2994702617A5070771458 @default.
• W2994702617 hasAuthorship W2994702617A5086602793 @default.
• W2994702617 hasAuthorship W2994702617A5087537091 @default.
• W2994702617 hasBestOaLocation W29947026171 @default.
• W2994702617 hasConcept C104317684 @default.
• W2994702617 hasConcept C126322002 @default.
• W2994702617 hasConcept C150194340 @default.
• W2994702617 hasConcept C152724338 @default.
• W2994702617 hasConcept C162317418 @default.
• W2994702617 hasConcept C18431079 @default.
• W2994702617 hasConcept C2778997737 @default.
• W2994702617 hasConcept C502942594 @default.
• W2994702617 hasConcept C509974204 @default.
• W2994702617 hasConcept C54355233 @default.
• W2994702617 hasConcept C555283112 @default.
• W2994702617 hasConcept C70721500 @default.
• W2994702617 hasConcept C71924100 @default.
• W2994702617 hasConcept C86803240 @default.
• W2994702617 hasConceptScore W2994702617C104317684 @default.
• W2994702617 hasConceptScore W2994702617C126322002 @default.
• W2994702617 hasConceptScore W2994702617C150194340 @default.
• W2994702617 hasConceptScore W2994702617C152724338 @default.
• W2994702617 hasConceptScore W2994702617C162317418 @default.
• W2994702617 hasConceptScore W2994702617C18431079 @default.
• W2994702617 hasConceptScore W2994702617C2778997737 @default.
• W2994702617 hasConceptScore W2994702617C502942594 @default.
• W2994702617 hasConceptScore W2994702617C509974204 @default.
• W2994702617 hasConceptScore W2994702617C54355233 @default.
• W2994702617 hasConceptScore W2994702617C555283112 @default.

• next