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- W2994710024 endingPage "144" @default.
- W2994710024 startingPage "127" @default.
- W2994710024 abstract "Throughout life, bones are subjected to the so-called ‘bone-remodeling’ process, which is a balanced mechanism between the apposition and the resorption of bone. This remodeling process depends on the activities of bone-specialized cells, namely the osteoblasts and the osteoclasts. Any deregulation in this process results in bone-related pathologies, classified as either metabolic nonmalignant diseases (such as osteoporosis) or malignant primary bone sarcomas. As these pathologies are not characterized by common targetable genetic alterations, epigenetic strategies could be relevant and promising options. Recently, targeting epigenetic regulators such as the bromodomains and extraterminal domains (BET) readers have achieved success in numerous other pathologies, including cancers. In this review, we highlight the current state of the art in terms of the diverse implications of BET bromodomain proteins in the bone’s biology and its defects. Consequently, their role in bone-related pathologies will also be developed, especially in the context of the primary bone sarcomas." @default.
- W2994710024 created "2019-12-26" @default.
- W2994710024 creator A5011209723 @default.
- W2994710024 creator A5030896487 @default.
- W2994710024 creator A5037692178 @default.
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- W2994710024 creator A5062884030 @default.
- W2994710024 creator A5070019661 @default.
- W2994710024 creator A5086139671 @default.
- W2994710024 date "2020-01-01" @default.
- W2994710024 modified "2023-10-01" @default.
- W2994710024 title "BET bromodomains’ functions in bone-related pathologies" @default.
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