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- W2994710074 abstract "Early diagnosis of cancer improves the efficacy of curative therapies. However, due to the difficulties involved in distinguishing between small early-stage tumors and normal biological variation, early detection of cancer is an extremely challenging task and there are currently no clinically validated biomarkers for a pan-cancer screening test. It is thus of particular significance that increasing evidence indicates the potential of circulating tumor DNA (ctDNA) molecules, which are fragmented segments of DNA shed from tumor cells into adjacent body fluids and the circulatory system, to serve as molecular markers for early cancer detection and thereby allow early intervention and improvement of therapeutic and survival outcomes. This is possible because ctDNA molecules bear cancer-specific fragmentation patterns, nucleosome depletion motifs, and genetic and epigenetic alterations, as distinct from plasma DNA originating from non-cancerous tissues/cells. Compared to traditional biomarkers, ctDNA analysis therefore presents the distinctive advantage of detecting tumor-specific alterations. However, based on a thorough survey of the literature, theoretical and empirical evidence suggests that current ctDNA analysis strategies, which are mainly based on DNA mutation detection, do not demonstrate the necessary diagnostic sensitivity and specificity that is required for broad clinical implementation in a screening context. Therefore, in this review we explain the biological, physiological, and analytical challenges toward the development of clinically meaningful ctDNA tests. In addition, we explore some approaches that can be implemented in order to increase the sensitivity and specificity of ctDNA assays." @default.
- W2994710074 created "2019-12-26" @default.
- W2994710074 creator A5064958931 @default.
- W2994710074 creator A5077502588 @default.
- W2994710074 creator A5082183159 @default.
- W2994710074 date "2019-12-22" @default.
- W2994710074 modified "2023-10-17" @default.
- W2994710074 title "Early detection of cancer using circulating tumor DNA: biological, physiological and analytical considerations" @default.
- W2994710074 cites W130099911 @default.
- W2994710074 cites W144306197 @default.
- W2994710074 cites W1509457944 @default.
- W2994710074 cites W1533135466 @default.
- W2994710074 cites W1680591717 @default.
- W2994710074 cites W1774283489 @default.
- W2994710074 cites W1893269340 @default.
- W2994710074 cites W1964296296 @default.
- W2994710074 cites W1982725285 @default.
- W2994710074 cites W1982836389 @default.
- W2994710074 cites W1983466841 @default.
- W2994710074 cites W1985805774 @default.
- W2994710074 cites W1989498651 @default.
- W2994710074 cites W1995740214 @default.
- W2994710074 cites W2003475924 @default.
- W2994710074 cites W2007837805 @default.
- W2994710074 cites W2014882257 @default.
- W2994710074 cites W2015438948 @default.
- W2994710074 cites W2017324325 @default.
- W2994710074 cites W2020309252 @default.
- W2994710074 cites W2027735722 @default.
- W2994710074 cites W2027884659 @default.
- W2994710074 cites W2029374735 @default.
- W2994710074 cites W2029861487 @default.
- W2994710074 cites W2039400792 @default.
- W2994710074 cites W2039912761 @default.
- W2994710074 cites W2040448034 @default.
- W2994710074 cites W2040563958 @default.
- W2994710074 cites W2040928840 @default.
- W2994710074 cites W2050664443 @default.
- W2994710074 cites W2051974123 @default.
- W2994710074 cites W2054039272 @default.
- W2994710074 cites W2056226885 @default.
- W2994710074 cites W2066939977 @default.
- W2994710074 cites W2068376654 @default.
- W2994710074 cites W2069376956 @default.
- W2994710074 cites W2076154138 @default.
- W2994710074 cites W2077248943 @default.
- W2994710074 cites W2078179820 @default.
- W2994710074 cites W2079345276 @default.
- W2994710074 cites W2082850021 @default.
- W2994710074 cites W2086261989 @default.
- W2994710074 cites W2089470652 @default.
- W2994710074 cites W2103081012 @default.
- W2994710074 cites W2107680358 @default.
- W2994710074 cites W2115093090 @default.
- W2994710074 cites W2120869188 @default.
- W2994710074 cites W2126816979 @default.
- W2994710074 cites W2129899300 @default.
- W2994710074 cites W2131641641 @default.
- W2994710074 cites W2134232003 @default.
- W2994710074 cites W2140575188 @default.
- W2994710074 cites W2145380439 @default.
- W2994710074 cites W2152241467 @default.
- W2994710074 cites W2160541773 @default.
- W2994710074 cites W2162949402 @default.
- W2994710074 cites W2163494229 @default.
- W2994710074 cites W2165541556 @default.
- W2994710074 cites W2168060493 @default.
- W2994710074 cites W2168078340 @default.
- W2994710074 cites W2168326351 @default.
- W2994710074 cites W2171237493 @default.
- W2994710074 cites W2173818354 @default.
- W2994710074 cites W2198964395 @default.
- W2994710074 cites W2231747349 @default.
- W2994710074 cites W2239118478 @default.
- W2994710074 cites W2280342795 @default.
- W2994710074 cites W2287342701 @default.
- W2994710074 cites W2288310435 @default.
- W2994710074 cites W2298824325 @default.
- W2994710074 cites W2329906190 @default.
- W2994710074 cites W2425479000 @default.
- W2994710074 cites W2436138214 @default.
- W2994710074 cites W2464329385 @default.
- W2994710074 cites W2467136872 @default.
- W2994710074 cites W2479380037 @default.
- W2994710074 cites W2479773785 @default.
- W2994710074 cites W2507892764 @default.
- W2994710074 cites W2508833621 @default.
- W2994710074 cites W2517348684 @default.
- W2994710074 cites W2520504290 @default.
- W2994710074 cites W2522924305 @default.
- W2994710074 cites W2531153177 @default.
- W2994710074 cites W2547919483 @default.
- W2994710074 cites W2561358247 @default.
- W2994710074 cites W2566323743 @default.
- W2994710074 cites W2570290963 @default.
- W2994710074 cites W2582557722 @default.
- W2994710074 cites W2582660163 @default.
- W2994710074 cites W2586862787 @default.