Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994710144> ?p ?o ?g. }
- W2994710144 abstract "Abstract Background It was reported that tumor-expressed dickkopf-related (DKK) proteins affect micro-environment. However, the influence of DKK1 on colorectal cancer (CRC) liver oligometastases (CRCLOM) remains unclear. Methods CRC cases after resection of liver oligometastases were enrolled in Sun Yat-Sen University Cancer Center with intact clinical data. Serum DKK1 was detected by ELISA assay. Immunofluorescent staining examination for CD3 and CD8 in slices were also conducted. Results Among 65 patients included, the recurrence-free survival (RFS) and overall survival (OS) were significantly better in the low serum DKK1 group (RFS: P = 0.021; OS: P = 0.043). DKK1 was overexpressed in stage IV CRC patients in TCGA data. The number of CD8+ tumor-infiltrating lymphocytes (TILs) in invasive margin of CRC liver oligometastases was significantly higher in low serum DKK1 group ( P = 0.042). Conclusion Elevated serum DKK1 level was associated with poorer RFS and OS, and less CD8+ TILs in invasive margin in CRC liver oligometastases. DKK1 might serve as a supplementalprognostic factor for clinical risk score and a potential target for immunotherapy." @default.
- W2994710144 created "2019-12-26" @default.
- W2994710144 creator A5001281697 @default.
- W2994710144 creator A5013466769 @default.
- W2994710144 creator A5017055867 @default.
- W2994710144 creator A5019386123 @default.
- W2994710144 creator A5030636703 @default.
- W2994710144 creator A5036905517 @default.
- W2994710144 creator A5039568808 @default.
- W2994710144 creator A5047595691 @default.
- W2994710144 creator A5048521956 @default.
- W2994710144 creator A5060613630 @default.
- W2994710144 creator A5061604822 @default.
- W2994710144 creator A5075342540 @default.
- W2994710144 creator A5085712538 @default.
- W2994710144 creator A5090212332 @default.
- W2994710144 date "2019-12-01" @default.
- W2994710144 modified "2023-10-09" @default.
- W2994710144 title "Dickkopf-related protein 1, a new biomarker for local immune status and poor prognosis among patients with colorectal liver Oligometastases: a retrospective study" @default.
- W2994710144 cites W1564357553 @default.
- W2994710144 cites W1829409335 @default.
- W2994710144 cites W1940241680 @default.
- W2994710144 cites W1967073403 @default.
- W2994710144 cites W1982146826 @default.
- W2994710144 cites W1984136989 @default.
- W2994710144 cites W1998854709 @default.
- W2994710144 cites W2000159893 @default.
- W2994710144 cites W2009123057 @default.
- W2994710144 cites W2039215669 @default.
- W2994710144 cites W2039758892 @default.
- W2994710144 cites W2057199920 @default.
- W2994710144 cites W2084470612 @default.
- W2994710144 cites W2093488681 @default.
- W2994710144 cites W2094695058 @default.
- W2994710144 cites W2104705319 @default.
- W2994710144 cites W2110118771 @default.
- W2994710144 cites W2114843025 @default.
- W2994710144 cites W2118725257 @default.
- W2994710144 cites W2142300779 @default.
- W2994710144 cites W2149441684 @default.
- W2994710144 cites W2153932922 @default.
- W2994710144 cites W2158021558 @default.
- W2994710144 cites W2166316862 @default.
- W2994710144 cites W2339653391 @default.
- W2994710144 cites W2441236057 @default.
- W2994710144 cites W2561934907 @default.
- W2994710144 cites W2562410867 @default.
- W2994710144 cites W2740241927 @default.
- W2994710144 cites W2748065364 @default.
- W2994710144 cites W2750717426 @default.
- W2994710144 cites W2767597469 @default.
- W2994710144 cites W2773278295 @default.
- W2994710144 cites W2789900268 @default.
- W2994710144 cites W2791471171 @default.
- W2994710144 cites W2793126529 @default.
- W2994710144 cites W2805068318 @default.
- W2994710144 cites W2805420581 @default.
- W2994710144 cites W2889646458 @default.
- W2994710144 cites W2917235733 @default.
- W2994710144 cites W4231096603 @default.
- W2994710144 cites W4240340450 @default.
- W2994710144 doi "https://doi.org/10.1186/s12885-019-6399-1" @default.
- W2994710144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6909492" @default.
- W2994710144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31830954" @default.
- W2994710144 hasPublicationYear "2019" @default.
- W2994710144 type Work @default.
- W2994710144 sameAs 2994710144 @default.
- W2994710144 citedByCount "7" @default.
- W2994710144 countsByYear W29947101442020 @default.
- W2994710144 countsByYear W29947101442021 @default.
- W2994710144 countsByYear W29947101442023 @default.
- W2994710144 crossrefType "journal-article" @default.
- W2994710144 hasAuthorship W2994710144A5001281697 @default.
- W2994710144 hasAuthorship W2994710144A5013466769 @default.
- W2994710144 hasAuthorship W2994710144A5017055867 @default.
- W2994710144 hasAuthorship W2994710144A5019386123 @default.
- W2994710144 hasAuthorship W2994710144A5030636703 @default.
- W2994710144 hasAuthorship W2994710144A5036905517 @default.
- W2994710144 hasAuthorship W2994710144A5039568808 @default.
- W2994710144 hasAuthorship W2994710144A5047595691 @default.
- W2994710144 hasAuthorship W2994710144A5048521956 @default.
- W2994710144 hasAuthorship W2994710144A5060613630 @default.
- W2994710144 hasAuthorship W2994710144A5061604822 @default.
- W2994710144 hasAuthorship W2994710144A5075342540 @default.
- W2994710144 hasAuthorship W2994710144A5085712538 @default.
- W2994710144 hasAuthorship W2994710144A5090212332 @default.
- W2994710144 hasBestOaLocation W29947101441 @default.
- W2994710144 hasConcept C104317684 @default.
- W2994710144 hasConcept C121608353 @default.
- W2994710144 hasConcept C126322002 @default.
- W2994710144 hasConcept C137620995 @default.
- W2994710144 hasConcept C143998085 @default.
- W2994710144 hasConcept C167672396 @default.
- W2994710144 hasConcept C203014093 @default.
- W2994710144 hasConcept C2776231280 @default.
- W2994710144 hasConcept C2777491412 @default.
- W2994710144 hasConcept C2780140570 @default.
- W2994710144 hasConcept C2781197716 @default.
- W2994710144 hasConcept C526805850 @default.
- W2994710144 hasConcept C55493867 @default.