Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994714458> ?p ?o ?g. }
- W2994714458 endingPage "46" @default.
- W2994714458 startingPage "38" @default.
- W2994714458 abstract "Cystic fibrosis (CF) is commonly associated with compromised growth especially in severe cases when the pulmonary function (PFT) deteriorates. As growth optimization is an important aspect of CF management, this review will summarize the current knowledge on the prevalence of growth failure in CF patients, and focus on the mechanisms leading to poor growth, on the association of poor linear growth with reduced PFT and on recombinant human growth hormone (rhGH) therapy in CF patients.Despite the improvement in CF care in the last 2 decades, compromised linear growth is still quite prevalent. The pathophysiology of growth failure in CF is multifactorial. Malnutrition due to decreased energy intake increased energy expenditure and malabsorption of ingested nutrients secondary to pancreatic insufficiency, all probably play a major role in growth restriction. In addition, chronic inflammation characteristic of CF may contribute to growth failure via alteration in the GH-insulin-like growth factor 1 signaling and other changes in the growth plate. rhGH and new CFTR modulators may improve some growth parameters.Beyond optimizing nutrition and malabsorption, and controlling chronic inflammation, children with CF may benefit from the anabolic effects of rhGH therapy to improve their anthropometric parameters. Whether this translates into better PFT and improved long-term outcomes is yet to be determined." @default.
- W2994714458 created "2019-12-26" @default.
- W2994714458 creator A5033741752 @default.
- W2994714458 creator A5060886311 @default.
- W2994714458 creator A5082999911 @default.
- W2994714458 date "2020-02-01" @default.
- W2994714458 modified "2023-09-25" @default.
- W2994714458 title "Somatic growth in cystic fibrosis" @default.
- W2994714458 cites W1589654967 @default.
- W2994714458 cites W1758686867 @default.
- W2994714458 cites W1953315011 @default.
- W2994714458 cites W1963610361 @default.
- W2994714458 cites W1968096557 @default.
- W2994714458 cites W1969302053 @default.
- W2994714458 cites W1969971789 @default.
- W2994714458 cites W1973102414 @default.
- W2994714458 cites W1987687600 @default.
- W2994714458 cites W1990862668 @default.
- W2994714458 cites W1993655405 @default.
- W2994714458 cites W2004109787 @default.
- W2994714458 cites W2015286337 @default.
- W2994714458 cites W2024862309 @default.
- W2994714458 cites W2030338159 @default.
- W2994714458 cites W2035570146 @default.
- W2994714458 cites W2037741096 @default.
- W2994714458 cites W2038905091 @default.
- W2994714458 cites W2039122063 @default.
- W2994714458 cites W2040233646 @default.
- W2994714458 cites W2041861862 @default.
- W2994714458 cites W2042885651 @default.
- W2994714458 cites W2049236612 @default.
- W2994714458 cites W2050154156 @default.
- W2994714458 cites W2051016635 @default.
- W2994714458 cites W2055608573 @default.
- W2994714458 cites W2065570670 @default.
- W2994714458 cites W2070734706 @default.
- W2994714458 cites W2072738630 @default.
- W2994714458 cites W2073209658 @default.
- W2994714458 cites W2078824920 @default.
- W2994714458 cites W2088077244 @default.
- W2994714458 cites W2092831088 @default.
- W2994714458 cites W2095966808 @default.
- W2994714458 cites W2097338332 @default.
- W2994714458 cites W2098987367 @default.
- W2994714458 cites W2120012915 @default.
- W2994714458 cites W2120344000 @default.
- W2994714458 cites W2123090083 @default.
- W2994714458 cites W2123616746 @default.
- W2994714458 cites W2130526971 @default.
- W2994714458 cites W2140868856 @default.
- W2994714458 cites W2141780505 @default.
- W2994714458 cites W2147585754 @default.
- W2994714458 cites W2153159153 @default.
- W2994714458 cites W2160079691 @default.
- W2994714458 cites W2169941450 @default.
- W2994714458 cites W2210882547 @default.
- W2994714458 cites W2300224114 @default.
- W2994714458 cites W2323409755 @default.
- W2994714458 cites W2409712942 @default.
- W2994714458 cites W2412356238 @default.
- W2994714458 cites W2416454333 @default.
- W2994714458 cites W2494411494 @default.
- W2994714458 cites W2566166640 @default.
- W2994714458 cites W2585658713 @default.
- W2994714458 cites W2605061201 @default.
- W2994714458 cites W2609894191 @default.
- W2994714458 cites W2753803030 @default.
- W2994714458 cites W2768725023 @default.
- W2994714458 cites W2793344986 @default.
- W2994714458 cites W2795983817 @default.
- W2994714458 cites W2861222774 @default.
- W2994714458 cites W2897626245 @default.
- W2994714458 cites W2917538474 @default.
- W2994714458 cites W4206217612 @default.
- W2994714458 doi "https://doi.org/10.1097/med.0000000000000522" @default.
- W2994714458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31815786" @default.
- W2994714458 hasPublicationYear "2020" @default.
- W2994714458 type Work @default.
- W2994714458 sameAs 2994714458 @default.
- W2994714458 citedByCount "3" @default.
- W2994714458 countsByYear W29947144582021 @default.
- W2994714458 countsByYear W29947144582022 @default.
- W2994714458 crossrefType "journal-article" @default.
- W2994714458 hasAuthorship W2994714458A5033741752 @default.
- W2994714458 hasAuthorship W2994714458A5060886311 @default.
- W2994714458 hasAuthorship W2994714458A5082999911 @default.
- W2994714458 hasConcept C1008401 @default.
- W2994714458 hasConcept C126322002 @default.
- W2994714458 hasConcept C134018914 @default.
- W2994714458 hasConcept C170493617 @default.
- W2994714458 hasConcept C177713679 @default.
- W2994714458 hasConcept C2775960820 @default.
- W2994714458 hasConcept C2776914184 @default.
- W2994714458 hasConcept C2776938444 @default.
- W2994714458 hasConcept C2777152358 @default.
- W2994714458 hasConcept C2780439177 @default.
- W2994714458 hasConcept C2984496839 @default.
- W2994714458 hasConcept C551997983 @default.