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• W2994718524 abstract "Tobacco smoke’s harmful effects are well-known; the harmful effects of tobacco smoke have been well-investigated. Nicotine in tobacco smoke contributes to the pathogenesis of various conditions, such as lung cancer, coronary artery disease and asthma. A decade ago, a seemingly safer alternative to tobacco cigarettes was introduced- the E-cigarette. However, studies have found that E-cigarette smoke (ECS) not only induces DNA damage but also reduces DNA repair activity via BER and NER pathways. Further research conducted with cells damaged by Ultra-Violet (UV) light or hydrogen peroxide (H2O2) indicates that ECS can function as a comutagen; nicotine can amplify mutagenic activity by merging with other mutagens. The downstream metabolites derived from nicotine found in ECS put E-cigarette smokers at a higher risk for developing lung or bladder cancers or heart disease than their non-smoking counterparts. Overall, these findings are instrumental in our understanding of the harmful effects of ECS." @default.
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• W2994718524 date "2019-12-18" @default.
• W2994718524 modified "2023-10-02" @default.
• W2994718524 title "Nicotine in E-cigarette smoke: cancer culprit?" @default.
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• W2994718524 doi "https://doi.org/10.1007/s12079-019-00519-5" @default.
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