FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994722155> ?p ?o ?g. }

• W2994722155 endingPage "40" @default.
• W2994722155 startingPage "40" @default.
• W2994722155 abstract "Kuding tea (KT) is a traditional Chinese beverage rich in plant bioactives that may exhibit various health benefits. However, little is known about the safety of KT extract (KTE) when consumed long term at high doses as a dietary supplement. Therefore, in this study, we investigated aspects of the safety of KTE. Male C57BL/6 mice were fed a high-fat, high-fructose, Western-type diet (control) supplemented with either 12.88% γ-cyclodextrin (γCD), 7.12% KTE (comprising 0.15% ursolic acid, UA) encapsulated in 12.88% γCD (KTE-γCD), or 0.15% UA over a 6-week experimental period. The dietary treatments did not affect food intake, body weight or body composition. However, treatment with KTE-γCD, but not γCD and UA, increased liver weight and hepatic fat accumulation, which was accompanied by increased hepatic PPARγ and CD36 mRNA levels. KTE-γCD treatment elevated plasma cholesterol and CYP7A1 mRNA and protein levels compared to those in control mice. KTE-γCD substantially increased the mRNA and protein levels of hepatic CYP3A and GSTA1, which are central to the detoxification of drugs and xenobiotics. Furthermore, we observed a moderate elevation in hepatic CYP3A (5-fold change) and GSTA1 (1.7-fold change) mRNA levels in UA-fed mice. In vitro data collected in HepG2 cells indicated a dose-dependent increase in hepatic cytotoxicity in response to KTE treatment, which may have been partly mediated by UA. Overall, the present data may contribute to the safety assessment of KTE and suggest that KTE encapsulated in γCD affects liver fat storage and the hepatic phase I and phase II responses in mice." @default.
• W2994722155 created "2019-12-26" @default.
• W2994722155 creator A5019897740 @default.
• W2994722155 creator A5032384303 @default.
• W2994722155 creator A5039597324 @default.
• W2994722155 creator A5046065567 @default.
• W2994722155 creator A5054741610 @default.
• W2994722155 creator A5071079699 @default.
• W2994722155 creator A5074804441 @default.
• W2994722155 creator A5078024932 @default.
• W2994722155 date "2019-12-22" @default.
• W2994722155 modified "2023-09-25" @default.
• W2994722155 title "High Dietary Kuding Tea Extract Supplementation Induces Hepatic Xenobiotic-Metabolizing Enzymes—A 6-Week Feeding Study in Mice" @default.
• W2994722155 cites W1966140039 @default.
• W2994722155 cites W1991264125 @default.
• W2994722155 cites W2009083033 @default.
• W2994722155 cites W2010818369 @default.
• W2994722155 cites W2018152768 @default.
• W2994722155 cites W2018476510 @default.
• W2994722155 cites W2022837209 @default.
• W2994722155 cites W2059577515 @default.
• W2994722155 cites W2069327089 @default.
• W2994722155 cites W2086317119 @default.
• W2994722155 cites W2100401627 @default.
• W2994722155 cites W2111794488 @default.
• W2994722155 cites W2116500451 @default.
• W2994722155 cites W2120502353 @default.
• W2994722155 cites W2125332262 @default.
• W2994722155 cites W2129039800 @default.
• W2994722155 cites W2331769226 @default.
• W2994722155 cites W2334568976 @default.
• W2994722155 cites W2405856657 @default.
• W2994722155 cites W2498475603 @default.
• W2994722155 cites W2515068332 @default.
• W2994722155 cites W2558996269 @default.
• W2994722155 cites W2776728489 @default.
• W2994722155 cites W2789909617 @default.
• W2994722155 cites W2795774342 @default.
• W2994722155 cites W2799826389 @default.
• W2994722155 cites W2800640372 @default.
• W2994722155 cites W2803679037 @default.
• W2994722155 cites W2892009393 @default.
• W2994722155 cites W2899945248 @default.
• W2994722155 cites W2913097765 @default.
• W2994722155 cites W2921254740 @default.
• W2994722155 cites W2921412890 @default.
• W2994722155 doi "https://doi.org/10.3390/nu12010040" @default.
• W2994722155 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7019617" @default.
• W2994722155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31877869" @default.
• W2994722155 hasPublicationYear "2019" @default.
• W2994722155 type Work @default.
• W2994722155 sameAs 2994722155 @default.
• W2994722155 citedByCount "9" @default.
• W2994722155 countsByYear W29947221552020 @default.
• W2994722155 countsByYear W29947221552021 @default.
• W2994722155 countsByYear W29947221552023 @default.
• W2994722155 crossrefType "journal-article" @default.
• W2994722155 hasAuthorship W2994722155A5019897740 @default.
• W2994722155 hasAuthorship W2994722155A5032384303 @default.
• W2994722155 hasAuthorship W2994722155A5039597324 @default.
• W2994722155 hasAuthorship W2994722155A5046065567 @default.
• W2994722155 hasAuthorship W2994722155A5054741610 @default.
• W2994722155 hasAuthorship W2994722155A5071079699 @default.
• W2994722155 hasAuthorship W2994722155A5074804441 @default.
• W2994722155 hasAuthorship W2994722155A5078024932 @default.
• W2994722155 hasBestOaLocation W29947221551 @default.
• W2994722155 hasConcept C11824378 @default.
• W2994722155 hasConcept C126322002 @default.
• W2994722155 hasConcept C134018914 @default.
• W2994722155 hasConcept C170493617 @default.
• W2994722155 hasConcept C2779828298 @default.
• W2994722155 hasConcept C526171541 @default.
• W2994722155 hasConcept C62231903 @default.
• W2994722155 hasConcept C71924100 @default.
• W2994722155 hasConcept C86803240 @default.
• W2994722155 hasConceptScore W2994722155C11824378 @default.
• W2994722155 hasConceptScore W2994722155C126322002 @default.
• W2994722155 hasConceptScore W2994722155C134018914 @default.
• W2994722155 hasConceptScore W2994722155C170493617 @default.
• W2994722155 hasConceptScore W2994722155C2779828298 @default.
• W2994722155 hasConceptScore W2994722155C526171541 @default.
• W2994722155 hasConceptScore W2994722155C62231903 @default.
• W2994722155 hasConceptScore W2994722155C71924100 @default.
• W2994722155 hasConceptScore W2994722155C86803240 @default.
• W2994722155 hasIssue "1" @default.
• W2994722155 hasLocation W29947221551 @default.
• W2994722155 hasLocation W29947221552 @default.
• W2994722155 hasLocation W29947221553 @default.
• W2994722155 hasLocation W29947221554 @default.
• W2994722155 hasLocation W29947221555 @default.
• W2994722155 hasLocation W29947221556 @default.
• W2994722155 hasOpenAccess W2994722155 @default.
• W2994722155 hasPrimaryLocation W29947221551 @default.
• W2994722155 hasRelatedWork W1969025184 @default.
• W2994722155 hasRelatedWork W2025243002 @default.
• W2994722155 hasRelatedWork W2134283161 @default.
• W2994722155 hasRelatedWork W2167327445 @default.
• W2994722155 hasRelatedWork W2930171697 @default.

• next