FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994727703> ?p ?o ?g. }

• W2994727703 endingPage "47" @default.
• W2994727703 startingPage "41" @default.
• W2994727703 abstract "Introduction: Many breast cancer (BC) patients develop the disease bilaterally. The emergence of two tumors in the same host is unlikely to be a random co-incidence: bilateral BC (biBC) patients are enriched by women who are susceptible to this disease due to genetic or non-genetic factors.Areas covered: Data on molecular pathogenesis and translational aspects of biBC research are summarized.Expert opinion: Studies on concordant and discordant molecular events occurring in paired tumors resemble twin studies, as they help to reveal core components of BC pathogenesis and to analyze interactions between host factors and tumor phenotype. Mutation profiling of biBC pairs suggested that most biBCs are clonally independent malignancies, although some instances of presumably contralateral metastatic spread were shown as well. Many biBCs, especially synchronous ones, demonstrate the similarity of essential tumor characteristics, which can be explained by sharing of genetic background, hormonal milieu, metabolic environment, and external exposures. biBC is strongly associated with BC-predisposing germline mutations; therefore, clinical management of biBC patients must include comprehensive genetic testing. Some contralateral metachronous BCs demonstrate high-level microsatellite instability (MSI-H). MSI-H is sometimes observed in radiation- and chemotherapy-induced tumors; therefore, it is possible that some second BCs are causally related to the therapy applied for the first cancer. MSI-H tumors are responsive to immune checkpoint blockade; hence, MSI-H analysis is advisable for biBC molecular testing. Systematic cataloging of biBC molecular portraits is likely to provide valuable information on fundamental aspects of cancer pathogenesis." @default.
• W2994727703 created "2019-12-26" @default.
• W2994727703 creator A5028176998 @default.
• W2994727703 creator A5046042894 @default.
• W2994727703 date "2019-12-23" @default.
• W2994727703 modified "2023-10-16" @default.
• W2994727703 title "Systemic investigations into the molecular features of bilateral breast cancer for diagnostic purposes" @default.
• W2994727703 cites W1521028081 @default.
• W2994727703 cites W1794275407 @default.
• W2994727703 cites W1800288361 @default.
• W2994727703 cites W1836406189 @default.
• W2994727703 cites W1871202334 @default.
• W2994727703 cites W1986615997 @default.
• W2994727703 cites W1991900845 @default.
• W2994727703 cites W1997370781 @default.
• W2994727703 cites W1998370081 @default.
• W2994727703 cites W2004951433 @default.
• W2994727703 cites W2010588863 @default.
• W2994727703 cites W2020323778 @default.
• W2994727703 cites W2027181440 @default.
• W2994727703 cites W2032602380 @default.
• W2994727703 cites W2035935461 @default.
• W2994727703 cites W2042626794 @default.
• W2994727703 cites W2048067606 @default.
• W2994727703 cites W2051625979 @default.
• W2994727703 cites W2054015138 @default.
• W2994727703 cites W2062533095 @default.
• W2994727703 cites W2066710246 @default.
• W2994727703 cites W2066743066 @default.
• W2994727703 cites W2069206982 @default.
• W2994727703 cites W2091047429 @default.
• W2994727703 cites W2096283457 @default.
• W2994727703 cites W2098503539 @default.
• W2994727703 cites W2107990320 @default.
• W2994727703 cites W2125722551 @default.
• W2994727703 cites W2138733479 @default.
• W2994727703 cites W2142230152 @default.
• W2994727703 cites W2143174879 @default.
• W2994727703 cites W2161782612 @default.
• W2994727703 cites W2166489336 @default.
• W2994727703 cites W2194014097 @default.
• W2994727703 cites W2198590456 @default.
• W2994727703 cites W2395887422 @default.
• W2994727703 cites W2466633991 @default.
• W2994727703 cites W2472380744 @default.
• W2994727703 cites W2479518934 @default.
• W2994727703 cites W2606565056 @default.
• W2994727703 cites W2622499649 @default.
• W2994727703 cites W2737816050 @default.
• W2994727703 cites W2748606465 @default.
• W2994727703 cites W2755475109 @default.
• W2994727703 cites W2765480939 @default.
• W2994727703 cites W2807583220 @default.
• W2994727703 cites W2887939057 @default.
• W2994727703 cites W2889517321 @default.
• W2994727703 cites W2913650362 @default.
• W2994727703 cites W2914244619 @default.
• W2994727703 cites W2916274801 @default.
• W2994727703 cites W2945564879 @default.
• W2994727703 cites W2946317931 @default.
• W2994727703 cites W2956135855 @default.
• W2994727703 cites W2963846945 @default.
• W2994727703 cites W2963967924 @default.
• W2994727703 doi "https://doi.org/10.1080/14737159.2020.1705157" @default.
• W2994727703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31835926" @default.
• W2994727703 hasPublicationYear "2019" @default.
• W2994727703 type Work @default.
• W2994727703 sameAs 2994727703 @default.
• W2994727703 citedByCount "4" @default.
• W2994727703 countsByYear W29947277032020 @default.
• W2994727703 countsByYear W29947277032022 @default.
• W2994727703 countsByYear W29947277032023 @default.
• W2994727703 crossrefType "journal-article" @default.
• W2994727703 hasAuthorship W2994727703A5028176998 @default.
• W2994727703 hasAuthorship W2994727703A5046042894 @default.
• W2994727703 hasConcept C104317684 @default.
• W2994727703 hasConcept C109825262 @default.
• W2994727703 hasConcept C121608353 @default.
• W2994727703 hasConcept C126322002 @default.
• W2994727703 hasConcept C140752955 @default.
• W2994727703 hasConcept C180754005 @default.
• W2994727703 hasConcept C203014093 @default.
• W2994727703 hasConcept C2779134260 @default.
• W2994727703 hasConcept C2779767149 @default.
• W2994727703 hasConcept C2780942790 @default.
• W2994727703 hasConcept C30481170 @default.
• W2994727703 hasConcept C502942594 @default.
• W2994727703 hasConcept C530470458 @default.
• W2994727703 hasConcept C54355233 @default.
• W2994727703 hasConcept C60644358 @default.
• W2994727703 hasConcept C61320498 @default.
• W2994727703 hasConcept C71924100 @default.
• W2994727703 hasConcept C86803240 @default.
• W2994727703 hasConceptScore W2994727703C104317684 @default.
• W2994727703 hasConceptScore W2994727703C109825262 @default.
• W2994727703 hasConceptScore W2994727703C121608353 @default.
• W2994727703 hasConceptScore W2994727703C126322002 @default.
• W2994727703 hasConceptScore W2994727703C140752955 @default.

• next