FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994741305> ?p ?o ?g. }

• W2994741305 endingPage "113049" @default.
• W2994741305 startingPage "113049" @default.
• W2994741305 abstract "Recently, the new psychoactive substance (NPS) ketamine analogue 2-fluoro-deschloroketamine (2FDCK) was observed in driving-under-the-influence-of-drugs whole blood samples and in a forensic hair investigation case in Denmark. The molecular structure variations among the NPS subgroups may alter the metabolic fate and drug potency, thereby posing a threat for drug users. This study reports quantification of 2FDCK in whole blood samples and forensic hair and compares the following toxicokinetic parameters: unbound fraction (fu) and in vitro–in vivo-extrapolation (IVIVE) of hepatic clearance for ketamine, norketamine, 2FDCK, methoxetamine and deschloroketamine. The fu was investigated with ultrafiltration, while clearance studies were conducted at 1 μM with pooled human liver microsomes. Samples were analysed by liquid chromatography and mass spectrometry. For the first time, 2FDCK was determined in a concentration range between 0.005 and 0.48 mg/kg in blood samples. Segmental hair analysis demonstrated 2FDCK at concentrations from 0.007 to 0.034 ng/mg throughout the three investigated segments. Toxicokinetic comparison of the five compounds gave a fu between 0.54 and 0.84, with ketamine being the most bound and deschloroketamine being the least bound, in accordance with the logP of the compounds. Conversely, a negative correlation was observed between the molecular weight of the halogen in the ortho-position and IVIVE hepatic clearance. The IVIVE of hepatic clearance, CLparallel-tube, gave values from 18.1 to 5.44 mL/min/kg for ketamine and methoxetamine, respectively. The deschloroketamine IVIVE was disregarded due to low drug elimination under the experimental conditions used. This study provides a basis for toxicokinetic understanding of ketamine analogues." @default.
• W2994741305 created "2019-12-26" @default.
• W2994741305 creator A5004134620 @default.
• W2994741305 creator A5004937841 @default.
• W2994741305 creator A5013055423 @default.
• W2994741305 creator A5044990552 @default.
• W2994741305 creator A5077697009 @default.
• W2994741305 creator A5078174062 @default.
• W2994741305 creator A5088420056 @default.
• W2994741305 creator A5088992462 @default.
• W2994741305 date "2020-02-01" @default.
• W2994741305 modified "2023-10-13" @default.
• W2994741305 title "Ketamine analogues: Comparative toxicokinetic in vitro–in vivo extrapolation and quantification of 2-fluorodeschloroketamine in forensic blood and hair samples" @default.
• W2994741305 cites W1595187506 @default.
• W2994741305 cites W1845759787 @default.
• W2994741305 cites W1961364466 @default.
• W2994741305 cites W1993012568 @default.
• W2994741305 cites W2020987809 @default.
• W2994741305 cites W2027994548 @default.
• W2994741305 cites W2041033086 @default.
• W2994741305 cites W2045075041 @default.
• W2994741305 cites W2054448558 @default.
• W2994741305 cites W2060192760 @default.
• W2994741305 cites W2094379342 @default.
• W2994741305 cites W2158691492 @default.
• W2994741305 cites W2240091231 @default.
• W2994741305 cites W2346478710 @default.
• W2994741305 cites W2418690536 @default.
• W2994741305 cites W2544255560 @default.
• W2994741305 cites W2562182809 @default.
• W2994741305 cites W2599106975 @default.
• W2994741305 cites W2783592813 @default.
• W2994741305 cites W2811304329 @default.
• W2994741305 cites W2898503255 @default.
• W2994741305 cites W2899190363 @default.
• W2994741305 cites W2907192831 @default.
• W2994741305 cites W2945066276 @default.
• W2994741305 doi "https://doi.org/10.1016/j.jpba.2019.113049" @default.
• W2994741305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31881397" @default.
• W2994741305 hasPublicationYear "2020" @default.
• W2994741305 type Work @default.
• W2994741305 sameAs 2994741305 @default.
• W2994741305 citedByCount "24" @default.
• W2994741305 countsByYear W29947413052020 @default.
• W2994741305 countsByYear W29947413052021 @default.
• W2994741305 countsByYear W29947413052022 @default.
• W2994741305 countsByYear W29947413052023 @default.
• W2994741305 crossrefType "journal-article" @default.
• W2994741305 hasAuthorship W2994741305A5004134620 @default.
• W2994741305 hasAuthorship W2994741305A5004937841 @default.
• W2994741305 hasAuthorship W2994741305A5013055423 @default.
• W2994741305 hasAuthorship W2994741305A5044990552 @default.
• W2994741305 hasAuthorship W2994741305A5077697009 @default.
• W2994741305 hasAuthorship W2994741305A5078174062 @default.
• W2994741305 hasAuthorship W2994741305A5088420056 @default.
• W2994741305 hasAuthorship W2994741305A5088992462 @default.
• W2994741305 hasConcept C150903083 @default.
• W2994741305 hasConcept C158342456 @default.
• W2994741305 hasConcept C178790620 @default.
• W2994741305 hasConcept C185592680 @default.
• W2994741305 hasConcept C195289149 @default.
• W2994741305 hasConcept C207001950 @default.
• W2994741305 hasConcept C2780795376 @default.
• W2994741305 hasConcept C2781233306 @default.
• W2994741305 hasConcept C29730261 @default.
• W2994741305 hasConcept C42219234 @default.
• W2994741305 hasConcept C43617362 @default.
• W2994741305 hasConcept C51639874 @default.
• W2994741305 hasConcept C55493867 @default.
• W2994741305 hasConcept C71924100 @default.
• W2994741305 hasConcept C86803240 @default.
• W2994741305 hasConcept C98274493 @default.
• W2994741305 hasConceptScore W2994741305C150903083 @default.
• W2994741305 hasConceptScore W2994741305C158342456 @default.
• W2994741305 hasConceptScore W2994741305C178790620 @default.
• W2994741305 hasConceptScore W2994741305C185592680 @default.
• W2994741305 hasConceptScore W2994741305C195289149 @default.
• W2994741305 hasConceptScore W2994741305C207001950 @default.
• W2994741305 hasConceptScore W2994741305C2780795376 @default.
• W2994741305 hasConceptScore W2994741305C2781233306 @default.
• W2994741305 hasConceptScore W2994741305C29730261 @default.
• W2994741305 hasConceptScore W2994741305C42219234 @default.
• W2994741305 hasConceptScore W2994741305C43617362 @default.
• W2994741305 hasConceptScore W2994741305C51639874 @default.
• W2994741305 hasConceptScore W2994741305C55493867 @default.
• W2994741305 hasConceptScore W2994741305C71924100 @default.
• W2994741305 hasConceptScore W2994741305C86803240 @default.
• W2994741305 hasConceptScore W2994741305C98274493 @default.
• W2994741305 hasLocation W29947413051 @default.
• W2994741305 hasLocation W29947413052 @default.
• W2994741305 hasOpenAccess W2994741305 @default.
• W2994741305 hasPrimaryLocation W29947413051 @default.
• W2994741305 hasRelatedWork W2012264476 @default.
• W2994741305 hasRelatedWork W2071733688 @default.
• W2994741305 hasRelatedWork W2132017329 @default.
• W2994741305 hasRelatedWork W2166188214 @default.
• W2994741305 hasRelatedWork W2361408673 @default.
• W2994741305 hasRelatedWork W2437311625 @default.

• next