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- W2994758829 abstract "Seven members of signaling lymphocytic activation molecule (SLAM) family receptors (SFRs) are ubiquitously expressed on hematopoietic cells and they play critical roles in immune cell differentiation and activation. The engagement of these receptors transmits intracellular signaling mainly by recruiting SLAM-associated protein (SAP) and its related adaptors, EWS-FLI1-activated transcript-2 (EAT-2) and EAT-2-related transducer (ERT). The critical roles of SFRs and SAP-family adaptors are highlighted by the discovery that SAP is mutated in human X-linked lymphoproliferative (XLP1) disease in which the contact between T and B cells in germinal center and cytotoxic lymphocytes (NK cells and CD8+ T cells) function are severely compromised. These immune defects are closely associated with the defective antibody production and the high incidence of lymphoma in the patients with XLP1. In addition to these well-known functions, SLAM-SAP family is involved in NK cell education, a process describing NK cell functional competence. In this chapter, we will mainly discuss these unappreciated roles of SAP-dependent and SAP-independent SFR signaling in regulating MHC-I-independent NK cell education." @default.
- W2994758829 created "2019-12-26" @default.
- W2994758829 creator A5038851564 @default.
- W2994758829 creator A5057198937 @default.
- W2994758829 creator A5069096075 @default.
- W2994758829 creator A5069304173 @default.
- W2994758829 creator A5075413341 @default.
- W2994758829 date "2020-01-01" @default.
- W2994758829 modified "2023-10-16" @default.
- W2994758829 title "Regulation of MHC class I-independent NK cell education by SLAM family receptors" @default.
- W2994758829 cites W1482523072 @default.
- W2994758829 cites W1522096076 @default.
- W2994758829 cites W1535240987 @default.
- W2994758829 cites W1544597713 @default.
- W2994758829 cites W1562537954 @default.
- W2994758829 cites W1617977600 @default.
- W2994758829 cites W1830427486 @default.
- W2994758829 cites W1892561736 @default.
- W2994758829 cites W1915834039 @default.
- W2994758829 cites W1959773306 @default.
- W2994758829 cites W1968204784 @default.
- W2994758829 cites W1976255260 @default.
- W2994758829 cites W1979058918 @default.
- W2994758829 cites W1979063503 @default.
- W2994758829 cites W1980609474 @default.
- W2994758829 cites W1983266259 @default.
- W2994758829 cites W1987654982 @default.
- W2994758829 cites W1988090285 @default.
- W2994758829 cites W1989712520 @default.
- W2994758829 cites W1990297263 @default.
- W2994758829 cites W1990585054 @default.
- W2994758829 cites W1993705617 @default.
- W2994758829 cites W1995591132 @default.
- W2994758829 cites W1998106591 @default.
- W2994758829 cites W1999092913 @default.
- W2994758829 cites W2000815213 @default.
- W2994758829 cites W2002458980 @default.
- W2994758829 cites W2005765588 @default.
- W2994758829 cites W2006409600 @default.
- W2994758829 cites W2013249454 @default.
- W2994758829 cites W2014472703 @default.
- W2994758829 cites W2017435377 @default.
- W2994758829 cites W2017651916 @default.
- W2994758829 cites W2023858678 @default.
- W2994758829 cites W2025838903 @default.
- W2994758829 cites W2027193010 @default.
- W2994758829 cites W2031134093 @default.
- W2994758829 cites W2033428553 @default.
- W2994758829 cites W2036043979 @default.
- W2994758829 cites W2039638023 @default.
- W2994758829 cites W2047703351 @default.
- W2994758829 cites W2048245039 @default.
- W2994758829 cites W2051885016 @default.
- W2994758829 cites W2053041715 @default.
- W2994758829 cites W2054047951 @default.
- W2994758829 cites W2054726996 @default.
- W2994758829 cites W2061990213 @default.
- W2994758829 cites W2064357644 @default.
- W2994758829 cites W2066011015 @default.
- W2994758829 cites W2067353129 @default.
- W2994758829 cites W2072128608 @default.
- W2994758829 cites W2072584472 @default.
- W2994758829 cites W2075271989 @default.
- W2994758829 cites W2076124836 @default.
- W2994758829 cites W2077330278 @default.
- W2994758829 cites W2077387328 @default.
- W2994758829 cites W2081159182 @default.
- W2994758829 cites W2085180812 @default.
- W2994758829 cites W2086635082 @default.
- W2994758829 cites W2089345792 @default.
- W2994758829 cites W2090203797 @default.
- W2994758829 cites W2091898673 @default.
- W2994758829 cites W2094981791 @default.
- W2994758829 cites W2095411789 @default.
- W2994758829 cites W2097381209 @default.
- W2994758829 cites W2097532486 @default.
- W2994758829 cites W2099735526 @default.
- W2994758829 cites W2107170234 @default.
- W2994758829 cites W2108010609 @default.
- W2994758829 cites W2115275175 @default.
- W2994758829 cites W2117690348 @default.
- W2994758829 cites W2119784585 @default.
- W2994758829 cites W2121158936 @default.
- W2994758829 cites W2122280942 @default.
- W2994758829 cites W2122440014 @default.
- W2994758829 cites W2122506182 @default.
- W2994758829 cites W2122510983 @default.
- W2994758829 cites W2123483303 @default.
- W2994758829 cites W2127834152 @default.
- W2994758829 cites W2128857896 @default.
- W2994758829 cites W2131189233 @default.
- W2994758829 cites W2135386379 @default.
- W2994758829 cites W2137698660 @default.
- W2994758829 cites W2138168141 @default.
- W2994758829 cites W2141083934 @default.
- W2994758829 cites W2150433660 @default.
- W2994758829 cites W2155344565 @default.
- W2994758829 cites W2155740187 @default.
- W2994758829 cites W2157588893 @default.
- W2994758829 cites W2159751093 @default.